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Erschienen in:
1992 | OriginalPaper | Buchkapitel
Use of Functionalized Poly(Ethylene Glycol)s for Modification of Polypeptides
verfasst von : Samuel Zalipsky, Chyi Lee
Erschienen in: Poly(Ethylene Glycol) Chemistry
Verlag: Springer US
Enthalten in: Professional Book Archive
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The unique properties of poly(ethylene glycol) (or PEG) and its general compatibility with polypeptide materials facilitated development of a variety of different applications of this polymer.1–11 A marked proportion of these applications involve the use of covalently linked polypeptide-PEG adducts (reviewed elsewhere5–11). For example, a number of PEG-enzymes were shown to be useful as catalysts, soluble and active in organic solvents.7 Due to the affinity to the upper phase of PEG/Dextran and PEG/salt two-phase systems, PEG-modified proteins were proven useful both as diagnostic tools8 and in preparative separations of biological cells.9