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Erschienen in:
2013 | OriginalPaper | Buchkapitel
A Cellular Automaton Model of the Effects of Maspin on Cell Migration
verfasst von : M. A. Al-Mamun, M. A. Hossain, M. S. Alam, R. Bass
Erschienen in: 7th International Conference on Practical Applications of Computational Biology & Bioinformatics
Verlag: Springer International Publishing
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Maspin (Mammary Serine Protease Inhibitor) is a non-inhibitory serpin with multiple cellular effects that is a type II tumour metastasis suppressor. Maspin has been shown to reduce cell migration, invasion, proliferation and angiogenesis, and increase apoptosis and adhesion. In this paper, we report the development of a mathematical model of the effects of maspin on cellular proliferation and migration. An artificial neural network has been used to model the unknown cell signalling to determine the cells fate. Results show that maspin reduces migration by between 10-35%; confirmed by published
in vitro
data. From our knowledge, this is the first attempt to model maspin effects in a computational model to verify
in vitro
data. This will provide new insights into to the tumour suppressive properties of maspin and inform the development of novel cancer therapy.