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Journal of Materials Science
Erschienen in: Journal of Materials Science 12/2019

11.03.2019 | Materials for life sciences

A novel controllable molecularly imprinted drug delivery system based on the photothermal effect of graphene oxide quantum dots

verfasst von: Yarong Xu, Xiaoling Hu, Ping Guan, Chunbao Du, Yuan Tian, Shichao Ding, Zhiling Li, Chaoren Yan

Erschienen in: Journal of Materials Science | Ausgabe 12/2019

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Abstract

Design and development of nanoparticle-based drug delivery systems (DDS) have always been extremely challenging due to unacceptable leakage of drug or unsatisfactory release in the lesion. Herein, we presented an effective approach for facile preparation of DDS by imprinting doxorubicin (DOX) via miniemulsion polymerization. In order to investigate the release of DOX in this system, the cumulative release of DOX by molecularly imprinted polymers (GMIPs) and non-imprinted polymers (GNIPs) was compared. The results revealed that the DOX’s leakage of GMIPs was more moderate than that of GNIPs. Moreover, after fitting the release curves with several mathematical models, it was found that the release of DOX from the GMIPs can be partially fitted with zero-order model (R2 = 0.929) which implied that molecular imprinting techniques for drug loading could reduce the common ‘burst effect.’ In addition, excellent release of DOX with controllable property was achieved by switching photothermal effect of graphene oxide quantum dots which were doped in GMIPs as the near-infrared light (NIR) window. Thus, it would be anticipated that the novel drug-loaded GMIPs combining with inductive NIR heating would be promising to be applied in the synergy of chemotherapy and thermotherapy for cancer therapy.
Vorheriger Artikel Molten-NaNH2 activated carbon cloth with high areal capacitance and exceptional rate stability for flexible asymmetric supercapacitors
Nächster Artikel Silica nanoparticles with dual visible–NIR luminescence affected by silica confinement of Tb(III) and Yb(III) complexes for cellular imaging application

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Metadaten
Titel
A novel controllable molecularly imprinted drug delivery system based on the photothermal effect of graphene oxide quantum dots
verfasst von
Yarong Xu
Xiaoling Hu
Ping Guan
Chunbao Du
Yuan Tian
Shichao Ding
Zhiling Li
Chaoren Yan
Publikationsdatum
11.03.2019
Verlag
Springer US
Erschienen in
Journal of Materials Science / Ausgabe 12/2019
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-019-03500-0

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