nach oben

Journal of Nanoparticle Research

Erschienen in:

01.11.2013 | Research Paper

Advanced nanocarriers for an antitumor peptide

verfasst von: Natassa Pippa, Stergios Pispas, Costas Demetzos, Gregory Sivolapenko

Erschienen in: Journal of Nanoparticle Research | Ausgabe 11/2013

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config

KI-gestützte Suche

Aus

Abstract

In this work, tigapotide (PCK3145) was incorporated into novel nanocarriers based on polymeric, lipidic, and dendrimeric components, in order to maximize the advantages of the drug delivery process and possibly its biological properties. PCK3145 was incorporated into lipidic nanocarriers composed of Egg phosphatidylcholine (EggPC) and dipalmytoylphosphatidylcholine (DPPC) (EggPC:PCK3145 and DPPC:PCK3145, 9:0.2 molar ratio), into cationic liposomes composed of EggPC:SA:PCK3145 and DPPC:SA:PCK3145 (9:1:0.2 molar ratio) into complexes with the block polyelectrolyte (quaternized poly[3,5-bis(dimethylaminomethylene)hydroxystyrene]-b-poly(ethylene oxide) (QNPHOSEO) and finally into dendrimeric structures (i.e., PAMAM G4). Light scattering techniques are used in order to examine the size, the size distribution and the Z-potential of the nanocarriers in aqueous and biological media. Fluorescence spectroscopy was utilized in an attempt to extract information on the internal nanostructure and microenvironment of polyelectrolyte/PCK3145 aggregates. Therefore, these studies could be a rational roadmap for producing various effective nanocarriers in order to ameliorate the pharmacokinetic behavior and safety issues of antitumor and anticancer biomolecules.

Vorheriger Artikel A facile preparation of Pt–Ru nanoparticles supported on polyaniline modified fullerene [60] for methanol oxidation

Nächster Artikel On the spectral difference between electroluminescence and photoluminescence of Si nanocrystals: a mechanism study of electroluminescence

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Ainalem ML, Campbell RA, Khalid S, Gillams RJ, Rennie AR, Nylander T (2010) On the ability of PAMAM dendrimers and dendrimer/DNA aggregated to penetrate POPC model biomembranes. J Phys Chem B 114(21):7229–7244CrossRef

Al-Tahami K, Singh J (2007) Smart polymer based delivery systems for peptides and proteins. Recent Pat Drug Deliv Formul 1:65–71CrossRef

Amado E, Blume A, Kressler J (2009) Novel non-ionic block copolymers tailored for interaction with phospholipids. React Funct Polym 69:450–456CrossRef

Annabi B, Bouzeghrane M, Currie JC, Hawkins R, Dulude H, Daigneault L, Ruiz M, Wisniewski J, Garde S, Rabbani SA, Panchal C, Wu JJ, Béliveau R (2005) APSP94-derived peptide PCK3145 inhibits MMP-9 secretion and triggers CD44 cell surface shedding: implication in tumor metastasis. Clin Exp Metastasis 22:429–439CrossRef

Annabi B, Bouzeghrane M, Currie JC, Dulude H, Daigneault L, Garde S, Rabbani SA, Panchal C, Wu JJ, Béliveau R (2006) Inhibition of MMP-9 secretion by anti-metastatic PSP-94derived peptide PCK3145 requires cell surface laminin receptor signaling. Anticancer Drugs 17:429–438CrossRef

Arnida Janát-Amsbury MM, Ray A, Peterson CM, Chandehari H (2011) Geometry and surface characteristics of gold nanoparticles influence their distribution and uptake by macrophages. Eur J Pharm Biopharm 77:417–423CrossRef

Asthana A, Chauhan AS, Diwan PV, Jain NK (2005) Poly(amidoamine) (PAMAM) dendritic nanostructures for controlled site-specific delivery of acidic anti-inflammatory active ingredient. AAPS PharmSciTech 6(3):E536–E542CrossRef

Aulenta F, Hayes W, Rannard S (2003) Dendrimers a new class of nanoscopic containers and delivery devices. Eur Polym J 39:1741–1771CrossRef

Bangham AD, Standish MM, Watkins JC (1965) Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol 13:238–252CrossRef

Becker AL, Henzler K, Welsch N, Ballauff M, Borisov O (2012) Proteins and polyelectrolytes: a charged relationship. Curr Opin Colloid Interface Sci 17:90–96CrossRef

Bonicelli MG, Giasanti L, Ierino M, Mancini G (2011) Interaction of cationic liposomes with cell membrane models. J Colloid Interface Sci 355:1–8CrossRef

Burchard W (1983) Static and dynamic light scattering from branched polymers and biopolymers. Adv Polym Sci 48:1–124CrossRef

Capriotti AL, Garacciolo G, Gavaliere C, Foglia P, Pozzi D, Samperi R, Laganá A (2012) Do plasma proteins distinguish between liposomes of varying charge density? J Proteomics 75:1924–1932CrossRef

Chauhan AS, Diwan PV, Jain NK, Tomalia DA (2009) Unexpected in vivo anti-inflammatory activity observed for simple, surface functionalized poly(amidoamine) dendrimers. Biomacromolecules 10:1195–1202CrossRef

Cheng Y, Xu Z, Ma M, Xu T (2008) Dendrimers as drug carriers: applications in different routes of drug administration. J Pharm Sci 97:123–143CrossRef

Choi YS, Cho TS, Kim JM, Han SW, Kim SK (2006) Amine terminated G-6 PAMAM dendrimer and its interaction with DNA probed by Hoeschst 33258. Biophys Chem 121(2):142–149CrossRef

Cloninger M (2002) Biological application of dendrimers. Curr Opin Chem Biol 6:742–748CrossRef

Crommelin DJ, Florence AT (2013) Towards more effective advanced drug delivery systems. Int J Pharm 454:496–511CrossRef

D’ Emanuele A, Attwood D (2005) Dendrimer–drug interactions. Adv Drug Deliv Rev 57:2147–2162CrossRef

Delgado AV, Conzález-Caballero F, Hunter RJ, Koopal LK, Lyklema J (2007) Measurement and interpretation of electrokinetic phenomena. J Colloid Interface Sci 309:194–224CrossRef

DeMattei CR, Huang B, Tomalia DA (2004) Designed dendrimer syntheses by self-assembly of single-site, ssDNA functionalized dendrons. Nano Lett 4:771–777CrossRef

Demetzos C (2006) Dendrimers as drug carriers: a new approach to increase the potential of bioactive natural products. Nat Prod Commun (NPC) 7:593–600

Eichman J, Bielinska A, Kukowska-Latallo J, Donovan B, Baker J (2001) In: Frechet J, Tomalia D (eds) Dendrimers and other demdritic polymers. Wiley, Chisester, pp 441–462

Esfand R, Tomalia DA (2001) Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications. Drug Discov Today 6:427–436CrossRef

Gardikis K, Tsimplouli C, Dimas K, Micha-Screttas M, Demetzos C (2010) New chimeric advanced drug delivery nano system (chi-aDDnSs) as doxorubicin carriers. Int J Pharm 402:231–237CrossRef

Gardikis K, Fessas D, Signorelli M, Dimas K, Tsimplouli C, Ionov M, Demetzos C (2011) A new chimeric drug delivery nano system (chi-aDDnS) composed of PAMAM-G4 G 3.5 dendrimer and liposomes as doxorubicin’s carrier. In vitro pharmacological studies. J Nanosci Nanotechnol 5:3764–3772CrossRef

Gregoriadis G, Wills EJ, Swain CP, Tavill AS (1974) Drug-carrier potential of liposomes in cancer chemotherapy. Lancet 1:1313–1316CrossRef

Gupta U, Agashe HB, Asthana A, Jain NK (2006) Dendrimers: novel polymeric nanoarchitectures for solubility enhancement. Biomacromolecules 7:649–658CrossRef

Jin GW, Koo H, Nam K, Kim H, Lee S, Park JS, Lee Y (2011) PAMAM dendrimer with a 1,2-diaminoethane surface facilitates endosomal escape for enhances pDNA delivery. Polymer 52:339–346CrossRef

Haladjova E, Rangelov S, Tsvetanov CB, Pispas S (2012) DNA encapsulation via nanotemplates from cationic block copolymer micelles. Soft Matter 8:2884–2889CrossRef

Hartig SM, Greene RR, DasGupta J, Carlesso G, Dikov MM, Prokop A, Danidson JM (2007) Multifunctional nanoparticulate polyelectrolyte complexes. Pharm Res 24:2353–2369CrossRef

Heutault B, Saulnier P, Pech B, Proust JE, Benoit JP (2003) Physico-chemical stability of colloidal lipid particles. Biomaterials 24:4283–4300CrossRef

Hofheinz RD, Gnad-Vogt SU, Beyer U, Hochhaus A (2005) Liposomal encapsulated anti-cancer drugs. Anticancer Drugs 16:691–707CrossRef

Jevprasesphant R, Penny J, Attwood D, D’Emanuele A (2004) Transport of dendrimer nanocarriers through epithelial cells via the transcellular route. J Controlled Release 97:259–267CrossRef

Kaditi E, Mountrichas G, Pispas S, Demetzos C (2012) Block copolymers for drug delivery nano systems (DDnSs). Curr Med Chem 19:5088–5100CrossRef

Kapoor M, Burgess DJ, Patil SD (2012) Physicochemical characterization techniques for lipid based delivery syatems for siRNA. Int J Pharm 427:35–57CrossRef

Karayianni M, Pispas S (2012) Complexation of stimuli-responsive star-like amphiphilic block polyelectrolyte micelles with lysozyme. Soft Matter 8:8758–8769CrossRef

Karayianni M, Pispas S, Chryssikos GD, Gionis V, Giatrellis S, Nounesis G (2011) Complexation of lysozyme with poly(sodium (sulfamate-carboxylate)isoprene). Biomacromolecules 12:1697–1706CrossRef

Law SL, Lo WY, Pai SH, The GW, Kou FY (1986) The adsorption of bovine serum albumin by liposomes. Int J Pharm 32:237–241CrossRef

Maingi V, Kumar MV, Maiti PK (2012) PAMAM dendrimer-drug interactions: effect of pH on the binding and release pattern. J Phys Chem B 116:4370–4376CrossRef

Mantzaridis C, Mountrichas G, Pispas S (2009) Complexes between high charge density cationic polyelectrolytes and anionic single- and double-tail surfactants. J Phys Chem B 113:7064–7070CrossRef

Menjoge AR, Kannan RM, Tomalia DA (2010) Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications. Drug Discov Today 15:171–185CrossRef

Mountrichas G, Pispas S (2007) Novel double hydrophilic block copolymers based on poly(p-hydroxystyrene) derivatives and poly(ethylene oxide). J Polym Sci Part A 45:5790–5799CrossRef

Mountrichas G, Mantzaridis C, Pispas S (2006) Well-defined flexible polyelectrolytes with two cationic sites per monomeric unit. Macromol Rapid Comm 27:289–294CrossRef

Ohki S, Arnold K (2000) A mechanism for ion-induced lipid fusion. Colloids Surf B 18:83–97CrossRef

Ohki S, Ohshima H (1999) Interaction and aggregation of lipid vesicles (DLVO theory versus modified DLVO theory). Colloids Surf B 14:27–45CrossRef

Pippa N, Pispas S, Demetzos C (2012a) The delineation of the morphology of charged liposomal vectors via a fractal analysis in aqueous and biological media: physicochemical and self-assembly studies. Int J Pharm 437:264–274CrossRef

Pippa N, Pispas S, Demetzos C (2012b) The fractal hologram and elucidation of the structure of liposomal carriers in aqueous and biological media. Int J Pharm 430:65–73CrossRef

Pippa N, Kaditi E, Pispas S, Demetzos C (2013a) PEO-b-PCL/DPPC chimeric nanocarriers: self-assembly aspects in aqueous and biological media and drug incorporation. Soft Matter 9:4073–4082CrossRef

Pippa N, Merkouraki M, Pispas S, Demetzos C (2013b) DPPC:MPOx chimeric advanced Drug Delivery nanosystems (chi-aDDnSs): physicochemical and structural characterization, stability and drug release studies. Int J Pharm 450:1–10CrossRef

Pippa N, Kaditi E, Pispas S, Demetzos C (2013c) DPPC/poly(2-methyl-2-oxazoline)-grad-poly(2-phenyl-2-oxazoline) chimeric nanostructures as potential drug nanocarriers. J Nanopart Res 15:1685CrossRef

Pippa N, Psarommati F, Pispas S, Demetzos C (2013d) The shape/morphology balance: a study of stealth liposomes via fractal analysis and drug encapsulation. Pharm Res 30:2385–2395CrossRef

Pispas S (2007) Complexes of lysozyme with sodium (sulfamate-carboxylate)isoprene/ethylene oxide double hydrophilic block copolymers. J Polym Sci Part A 45:509–520CrossRef

Reis CP, Ribeiro AJ, Veiga F, Neufeld RJ, Damgé C (2008) Polyelectrolyte biomaterial interactions provide nanoparticulate carrier for oral insulin delivery. Drug Deliv 15:127–139CrossRef

Rowland M, Noe CR, Smith DA, Tucker GT, Crommelin DJ, Peck CC, Rocci ML Jr, Basançon L, Shah VP (2012) Impact of the pharmaceutical sciences on health care: a reflection over the past 50 years. J Pharm Sci 101:4075–4099CrossRef

Ruozi B, Forni F, Battini R, Vandelli MA (2003) Cationic liposomes for gene transfection. J Drug Target 11:407–414CrossRef

Sabín J, Prieto G, Ruso JM, Messina PV, Salgado FJ, Nogueira M, Costas M, Sarmiento F (2009) Interactions between DMPC liposomes and the serum blood proteins HSA and IgG. J Phys Chem B 113:1655–1661CrossRef

Sadekar S, Ghandehari H (2012) Transepithelial transport and toxicity of PAMAM denedrimers: implications for oral drug delivery. Adv Drug Deliv Rev 64(6):571–588CrossRef

Shukeir N, Arakelian A, Chen G, Garde S, Ruiz M, Panchal C, Rabbani SA (2004) A synthetic 15mer peptide (PCK3145) derived from prostate secretory protein can reduce tumor growth, experimental skeletal metastases, and malignancy-associated hypercallcemia. Cancer Res 64:5370–5377CrossRef

Slingerland M, Guchelaar HJ, Gelderblom H (2012) Liposomal drug formulations in cancer therapy: 15 years along the road. Drug Discov Today 17:160–166CrossRef

Stepanek M, Matejicek P, Prochazka K, Filippov SK, Angelov B, Slouf M, Mountrichas G, Pispas S (2011) Polyelectrolyte-surfactant complexes formed by poly-[3,5-bis(trimethylammoniummethyl)-4-hydroxystyrene iodide]-block-poly(ethylene oxide) and sodium dodecyl sulfate in aqueous solutions. Langmuir 27:5275–5281CrossRef

Svenson S, Tomalia DA (2005) Dendrimers in biomedical applications—reflections on the field. Adv Drug Deliv Rev 57(15):2106–2129CrossRef

Tomalia DA (2009) In quest of a systematic framework for unifying and defining nanoscience. J Nanopart Res 11:1251–1310CrossRef

Tomalia DA, Baker H, Dewald J, Hall M, Kallos G, Martin S, Roeck J, Ryder J, Smith P (1985) A new class of polymers: starburst-dendritic macromolecules. Polym J 17:117–132CrossRef

Tomalia DA, Reyna LA, Svenson S (2007) Dendrimers as multi-purpose nanodevices for oncology drug delivery and diagnostic imaging. Biochem Soc Trans 35:61–67CrossRef

Torchilin VP (2004) Targeted polymeric micelles for delivery of poorly soluble drugs. Cell Mol Life Sci 61:2549–2559CrossRef

Torchilin VP (2007) Micellar Nanocarriers: pharmaceutical perspectives. Pharm Res 21:1–15

Vallianatou T, Tsantili-Kakoulidou A (2013) In silico methods of ADME(T) prediction: a brief review. Pharmakeftiki 25(II):55–67

Varkouhi AK, Mountrichas G, Schiffelers RM, Lammers T, Storm G, Pispas S, Hennik WE (2012) Polyplexes based on cationic polymers with strong nucleic acid binding properties. Eur J Pharm Sci 45:459–466CrossRef

Wu SY, McMillan NAJ (2009) Lipidic systems for in vivo siRNA delivery. AAPS J 11:639–652CrossRef

Titel: Advanced nanocarriers for an antitumor peptide
verfasst von: Natassa Pippa
Stergios Pispas
Costas Demetzos
Gregory Sivolapenko
Publikationsdatum: 01.11.2013
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 11/2013
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-013-2062-y

Premium Partner

Marktübersichten

Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen.

Zur Marktübersicht

Springer Professional

Abstract

Bitte loggen Sie sich ein, um Zugang zu Ihrer Lizenz zu erhalten.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Technik"

Weitere Artikel der Ausgabe 11/2013

Cationic nanoparticles with quaternary ammonium-functionalized PLGA–PEG-based copolymers for potent gene transfection

Nanotechnology and clean energy: sustainable utilization and supply of critical materials

A highly efficient nano-Fe3O4 encapsulated-silica particles bearing sulfonic acid groups as a solid acid catalyst for synthesis of 1,8-dioxo-octahydroxanthene derivatives

Development and evaluation of triclosan loaded poly-ε-caprolactone nanoparticulate system for the treatment of periodontal infections

Adsorption behavior and mechanism of methyl blue on zinc oxide nanoparticles

Pulsed laser deposition of a dense and uniform Au nanoparticles layer for surface plasmon enhanced efficiency hybrid solar cells

Premium Partner

Marktübersichten