nach oben

Erschienen in:

01.09.2008

Association of demographic, clinical and treatment variables with quality of life of patients with epilepsy in Greece

verfasst von: Charitomeni Piperidou, Anna Karlovasitou, Nikolaos Triantafyllou, Evagelia Dimitrakoudi, Aikaterini Terzoudi, Eleni Mavraki, Grigorios Trypsianis, Konstantinos Vadikolias, Ioannis Heliopoulos, Dimitrios Vassilopoulos, Stavros Balogiannis

Erschienen in: Quality of Life Research | Ausgabe 7/2008

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config

KI-gestützte Suche

Aus

Abstract

Purpose

The aim was to study the influence of patients’ age, frequency and type of seizures, disease duration, number of AEDs and use of benzodiazepines on the quality of life of patients with epilepsy.

Patients and methods

We consecutively identified 223 patients with epilepsy who attended the epilepsy outpatient clinics at three university hospitals in Greece. Quality of life was evaluated by QOLIE-31. One-way analysis was used to assess the association of the studied factors and QOLIE-31 subscales. After checking for co-linearity, we performed multivariate stepwise linear regression analysis with all the variables that on univariate analysis showed a statistically significant effect on each subscale of QOLIE-31 to explore which of the studied factors affect independently on QOLIE-31 scores.

Results

Of a total of 223 patients, 118 (52.95%) were men; mean age was 35.18 ± 13.22; mean duration of the disease was 13 years; 58 (26%) patients had generalized seizures, 93 (41.7%) had PS, and 72 (32.3%) of the patients had PsG; 85 (38.1%) were on polytherapy and 38 (17%) were taking benzodiazepines. Independent factors affecting QoL were: seizure frequency (Overall QoL P = 0.0001, Seizure worry and Emotional well-being P < 0.0001, Energy/fatigue and Social functioning P = 0.01); duration of the disease (Overall QoL and Energy/fatigue P = 0.01, Seizure worry P = 0.008, Cognitive functioning P < 0.0001); polytherapy only for the Emotional well-being P < 0.0001; and use of benzodiazepines (Overall QoL, Energy/fatigue, Social functioning P = 0.002, Cognitive functioning P < 0.0001).

Conclusion

Our findings suggest that QoL in epileptic patients might be affected, in addition to the other established factors (high frequency of seizures and polytherapy), by the daily use of benzodiazepines as adjunctive therapy. Change of medical strategy concerning this medication may lead to improving the QoL of these patients.

Vorheriger Artikel Health-related quality of life in young cocaine users and associated factors

Nächster Artikel Exploring response shift in the quality of life of healthy adolescents over 1 year

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 340 Zeitschriften

aus folgenden Fachgebieten:

Bauwesen + Immobilien
Business IT + Informatik
Finance + Banking
Management + Führung
Marketing + Vertrieb
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Devinsky, O., Vickrey, B. G., Cramer, J., et al. (1995). Development of the quality of life in epilepsy inventory. Epilepsia, 36, 1089–1104. doi:10.1111/j.1528-1157.1995.tb00467.x.PubMedCrossRef

Jacoby, A., & Baker, G. A. (2008). Quality-of-life trajectories in epilepsy: A review of the literature. Epilepsy & Behavior, 12(4), 557–571. doi:10.1016/j.yebeh.2007.11.013.CrossRef

European Declaration on Epilepsy. (2003). Epilepsia, 44(suppl. 6), 2–3.

Choi-Kwon, S., Chung, C., Kim, H., et al. (2003). Factors affecting the quality of life in patients with epilepsy in Seoul, South Korea. Acta Neurologica Scandinavica, 108, 428–434. doi:10.1046/j.1600-0404.2003.00151.x.PubMedCrossRef

Şenol, V., Soyuer, F., Arman, F., & Öztürk, A. (2007). Influence of fatigue, depression, and demographic, socioeconomic, and clinical variables on quality of life of patients with epilepsy. Epilepsy & Behavior, 10, 96–104. doi:10.1016/j.yebeh.2006.08.006.CrossRef

Baker, G., Gagnon, D., & McNulty, P. (1998). The relationship between seizure frequency, seizure type and quality of life: Findings from three European countries. Epilepsy Research, 30, 231–240. doi:10.1016/S0920-1211(98)00010-2.PubMedCrossRef

Guekht, A., Mitrokhina, T., & Lebedeva, A. (2007). Factors influencing on quality of life in people with epilepsy. Seizure, 16(2), 128–133. doi:10.1016/j.seizure.2006.10.011.PubMedCrossRef

Piazzini, A., Ramaglia, G., Turner, K., et al. (2007). Coping strategies in epilepsy: 50 drug-resistant and 50 seizure-free patients. Seizure, 16, 211–217. doi:10.1016/j.seizure.2006.12.003.PubMedCrossRef

Miller, V., Palermo, T. M., & Grewe, S. D. (2003). Quality of life in pediatric epilepsy: Demographic and disease-related predictors and comparison with health controls. Epilepsy & Behavior, 4, 36–42. doi:10.1016/S1525-5050(02)00601-7.CrossRef

10.

Szaflarski, M., Meckler, J., Privitera, M., & Szaflarski, J. (2006). Quality of life in medication-resistant epilepsy: The effects of patient’s age, age at onset, and disease duration. Epilepsy & Behavior, 8, 547–551. doi:10.1016/j.yebeh.2006.01.001.CrossRef

11.

Pirio Richardson, S., Tomaszewski Farias, S., Lima, R. A., III, & Alsaadi, M. T. (2004). Improvement in seizure control and quality of life in medically refractory epilepsy patients converted from polypharmacy to monotherapy. Epilepsy & Behavior, 5, 343–347. doi:10.1016/j.yebeh.2004.01.006.CrossRef

12.

De Weerd, A., De Haas, S., Otte, A., et al. (2004). Subjective sleep disturbance in patients with partial epilepsy: A questionnaire-based study on prevalence and impact on quality of life. Epilepsia, 11, 1397–1404. doi:10.1111/j.0013-9580.2004.46703.x.CrossRef

13.

Baker, G. A., Camfield, C., Cramer, J. A., Elger, C. E., et al. (1998). Commission on outcome measurement in epilepsy. Epilepsia, 39, 213–231. doi:10.1111/j.1528-1157.1998.tb01361.x.PubMedCrossRef

14.

Sachdeo, R. C., Gates, J. R., Bazil, C. W., Gregory, B. L., et al. (2006). Improved quality of life in patients with partial seizures after conversion to oxcarbazepine monotherapy. Epilepsy & Behavior, 3, 457–463.CrossRef

15.

Kaminow, L., Schimscock, J. R., Hammer, A. E., & Vuong, A. (2003). Lamotrigine monotherapy compared with carbamazepine, phenytoin, or valproate monotherapy in patients with epilepsy. Epilepsy & Behavior, 4, 659–666. doi:10.1016/j.yebeh.2003.08.033.CrossRef

16.

Cramer, J. A., Hammer, A. E., & Kustra, R. P. (2004). Quality of life improvement with conversion to lamotrigine monotherapy. Epilepsy & Behavior, 5, 224–230. doi:10.1016/j.yebeh.2003.11.031.CrossRef

17.

Kaiser, S., Selai, C. E., & Trimble, M. R. (2002). Long-term follow-up of topiramate and lamotrigine: A perspective on quality of life. Seizure, 11, 356–360. doi:10.1053/seiz.2002.0681.PubMedCrossRef

18.

Cramer, J. A., Van Hammé, G., & the N132 Study Group. (2003). Maintenance of improvement in health-related quality of life during long-term treatment with levetiracetam. Epilepsy & Behavior, 4, 118–123. doi:10.1016/S1525-5050(03)00004-0.CrossRef

19.

Cramer, J. A., Brandenburg, N. A., Xu, X., et al. (2007). The impact of seizures and adverse effects on global healt ratings. Epilepsy & Behavior, 11, 179–184. doi:10.1016/j.yebeh.2007.05.005.CrossRef

20.

Panagotopoulos, P. C. (2002). A clinical guide to epileptic syndromes and their treatment (p. 157). Oxford, UK: Bladon Medical Publishing.

21.

Montenegro, M. A., Cendes, F., Noronha, A. L. A., et al. (2001). Efficacy of clobazam as add-on therapy in patients with refractory partial epilepsy. Epilepsia, 42(4), 539–542. doi:10.1046/j.1528-1157.2001.31600.x.PubMedCrossRef

22.

Mehndiratta, M. M., Krishnamurthy, M., Rajesh, K. N., & Singh, G. (2003). Clobazam monotherapy in drug naïve adult patients with epilepsy. Seizure, 12, 226–228. doi:10.1016/S1059-1311(02)00263-7.PubMedCrossRef

23.

Sugai, K. (2004). Clobazam as a new antiepileptic drug and clorazepate dipotassium as an alternative antiepileptic drug in Japan. Epilepsia, 45(Suppl. 8), 20–25. doi:10.1111/j.0013-9580.2004.458005.x.PubMedCrossRef

24.

Leone, M. A., Beghi, E., Righini, C., et al. (2005). Epilepsy and quality of life in adults: A review of instruments. Epilepsy Research, 66, 23–44. doi:10.1016/j.eplepsyres.2005.02.009.PubMedCrossRef

25.

May, T., Pfäfflin, M., & Cramer, J. (2001). Psychometric properties of the German translation of the QOLIE-31. Epilepsy & Behavior, 2, 106–114. doi:10.1006/ebeh.2001.0170.CrossRef

26.

Torres, X., Arroyo, S., Araya, S., & De Pablo, J. (1999). The Spanish version of the Quality-of-Life in Epilepsy Inventory (QOLIE-31); Translation, validity and reliability. Epilepsia, 40(9), 1299–1304. doi:10.1111/j.1528-1157.1999.tb00861.x.PubMedCrossRef

27.

Picot, M. C., Crespel, A., Daures, J. P., Baldy-Moulinier, M., & El Hasnaui, A. (2004). Psychometric validation of the French version of the quality of life in epilepsy inventory (QOLIE-31): Comparison with a generic health-related quality of life questionnaire. Epileptic Disorders, 6, 275–285.PubMed

28.

De Silva, T. I., Ciconelli, R. M., Alonso, N. B., et al. (2007). Validity and reliability of the Portuguese version of quality of life in epilepsy inventory (QOLIE-31) for Brazil. Epilepsy & Behavior.

29.

Piperidou, H., Terzoudi, A., Vorvolakos, T., et al. (2006). The Greece version of the quality of life in epilepsy inventory (QOLIE-31). Quality of Life Research, 15, 833–839.PubMed

30.

Birbeck, G. L., Hays, R. D., Cui, X., & Vickrey, B. G. (2002). Seizure reduction and quality of life improvements in people with epilepsy. Epilepsia, 43(5), 535–538. doi:10.1046/j.1528-1157.2002.32201.x.PubMedCrossRef

31.

Birbeck, G. L., Kim, S., Hays, R. D., & Vickrey, B. G. (2000). Quality of life measures in epilepsy: How well can they detect change over time? Neurology, 54, 1822–1827.PubMed

32.

Cramer, J. A., Arrigo, C., Van Hammée, G., Gauer, L. J., Cereghino, J. J., & for the N132 Study Group. (2000). Effect of levetiracetam on epilepsy-related quality of life. Epilepsia, 41, 868–874. doi:10.1111/j.1528-1157.2000.tb00255.x.PubMedCrossRef

33.

Dodrill, C. B., & Morris, G. L. (2001). Effect of vagal nerve stimulation on cognition and quality of life in epilepsy. Epilepsy & Behavior, 2, 46–53. doi:10.1006/ebeh.2000.0148.CrossRef

34.

Kugoh, T. (1998). Quality of life research in adults with epilepsy in Japan. Clinical Therapeutics, 20(Suppl. A), A48–A57. doi:10.1016/S0149-2918(98)80024-6.PubMedCrossRef

35.

Lam, J., Rozsavolgyi, M., Soos, G., et al. (2001). Quality of life of patients with epilepsy (Hungarian survey). Seizure, 10, 100–106.PubMed

36.

Johnson, E. K., Jones, J. E., Seidenberg, M., & Herman, B. P. (2004). The relative impact of anxiety, depression, and clinical seizure features on health-related quality of life in epilepsy. Epilepsia, 45(5), 544–550. doi:10.1111/j.0013-9580.2004.47003.x.PubMedCrossRef

37.

Commission on Classification, Terminology of the International League Against Epilepsy. (1989). Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia, 30, 389–399.CrossRef

38.

Cramer, J., Perrine, K., Devinsky, O., et al. (1998). Development and cross-cultural translation of a 31-item Quality of life in Epilepsy Inventory. Epilepsia, 39(1), 81–88. doi:10.1111/j.1528-1157.1998.tb01278.x.PubMedCrossRef

39.

Vickrey, B. G., Perrine, K., Hays, R. D., et al. (1993). Quality of life in Epilepsy QOLIE-31 (version 1.0): Scoring Manual and Patient Inventory. Santa Monica, CA: RAND.

40.

Meldolesi, G., Picardi, A., Quarato, P., et al. (2006). Factors associated with generic and disease-specific quality of life in temporal lobe epilepsy. Epilepsy Research, 69, 135–146. doi:10.1016/j.eplepsyres.2006.01.010.PubMedCrossRef

41.

Boylan, L. S., Flint, L. A., Labovitz, D. L., et al. (2004). Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy. Neurology, 62, 258–261.PubMed

42.

Kellett, M. W., Smith, D. F., & Chadwick, D. W. (1997). Quality of life after epilepsy surgery. Journal of Neurology, Neurosurgery and Psychiatry, 63, 52–58.CrossRef

43.

Mikati, M. A., Comair, Y. G., & Rahi, A. (2006). Normalization of quality of life three years after temporal lobectomy: A controlled study. Epilepsia, 47(5), 928–933. doi:10.1111/j.1528-1167.2006.00523.x.PubMedCrossRef

44.

Smith, D. F., Baker, G. A., Davies, G., et al. (1993). Outcomes of add-on treatment with lamotrigine in partial epilepsy. Epilepsia, 34(2), 312–322. doi:10.1111/j.1528-1157.1993.tb02417.x.PubMedCrossRef

45.

Nubukpo, P., Clément, J. P., Houinato, D., et al. (2004). Psychosocial issues in people with epilepsy in Togo and Benin (West Africa) II. Quality of life measured using the QOLIE-31 scale. Epilepsy & Behavior, 5, 728–734. doi:10.1016/j.yebeh.2004.07.002.CrossRef

46.

Baker, G. A., Jacoby, A., Buck, D., et al. (2001). The quality of life of older people with epilepsy: Findings from a UK community study. Seizure, 42, 1160–1168.

47.

Sanjeev, V. T., Samuel, K., Nair, C. R. S., & Sarma, S. (2005). Frequent seizures and polytherapy can impair quality of life in person with epilepsy. Neurology India, 53(1), 46–50.CrossRef

48.

Uijl, S. G., Uterwaal, C. S. M. P., Aldenkamp, A. P., et al. (2006). A cross-sectional study of subjective complaints in patients with epilepsy who seem to be well-controlled with ant-epileptic drugs. Seizure, 15, 242–248. doi:10.1016/j.seizure.2006.02.009.PubMedCrossRef

49.

Deckers, C. L. P., Hekster, Y. A., Keyser, A., et al. (2001). Monotherapy versus polytherapy for epilepsy: A multicenter double-blind randomized study. Epilepsia, 42(11), 1387–1394. doi:10.1046/j.1528-1157.2001.30800.x.PubMedCrossRef

50.

Panayiotopoulos, C. P. (2005). THE EPILEPSIES. Seizures, Syndromes and Management (p. 500). UK: Bladon Medical Publishing.

51.

Stewart, H. S., & Westra, A. H. (2002). Benzodiazepine side-effects: From the bench to the clinic. Current Pharmaceutical Design, 8, 1–3. doi:10.2174/1381612023396708.PubMedCrossRef

52.

Bawden, H. N., Camfield, C. S., Camfield, P. R., et al. (1999). The cognitive and behavioural effects of clobazam and standard monotherapy are comparable. Canadian Study Group for childhood epilepsy. Epilepsy Research, 33(2–3), 133–143. doi:10.1016/S0920-1211(98)00088-6.PubMedCrossRef

53.

Henriksen, O. (1998). An overview of benzodiazepines in seizure management. Epilepsia, 39(Suppl. 1), s2–s6. doi:10.1111/j.1528-1157.1998.tb05110.x.CrossRef

54.

Homan, W. R., & Rosenberg, C. H. (1997). Benzodiazepines. In E. Wylle (Ed.), The treatment of epilepsy. Pennsylvania: Williams & Wilkins.

55.

Shorvon, S. (1995). Benzodiazepines: Clobazam. In R. H. Levy, R. H. Mattson & B. S. Meldrum (Eds.), Antiepileptic drugs (4th ed., pp. 763–777). New York: Raven Press.

Titel: Association of demographic, clinical and treatment variables with quality of life of patients with epilepsy in Greece
verfasst von: Charitomeni Piperidou
Anna Karlovasitou
Nikolaos Triantafyllou
Evagelia Dimitrakoudi
Aikaterini Terzoudi
Eleni Mavraki
Grigorios Trypsianis
Konstantinos Vadikolias
Ioannis Heliopoulos
Dimitrios Vassilopoulos
Stavros Balogiannis
Publikationsdatum: 01.09.2008
Verlag: Springer Netherlands
Erschienen in: Quality of Life Research / Ausgabe 7/2008
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-008-9375-9

Springer Professional

Abstract

Purpose

Patients and methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu Ihrer Lizenz zu erhalten.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Wirtschaft"

Weitere Artikel der Ausgabe 7/2008

How consistent are health utility values?

Exploring response shift in the quality of life of healthy adolescents over 1 year

Statistical methodology is crucial in prognostic factor analysis of health-related quality of life

Health-related quality of life in young cocaine users and associated factors

Improving a newly developed patient-reported outcome for thyroid patients, using cognitive interviewing

In reply to Mauer et al. “Statistical methodology is crucial in prognostic factor-analysis of health-related quality of life”

Premium Partner