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International Journal of Computer Assisted Radiology and Surgery

Erschienen in:

10.05.2017 | Original Article

BEM-based simulation of lung respiratory deformation for CT-guided biopsy

verfasst von: Dong Chen, Weisheng Chen, Lipeng Huang, Xuegang Feng, Terry Peters, Lixu Gu

Erschienen in: International Journal of Computer Assisted Radiology and Surgery | Ausgabe 9/2017

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Abstract

Purpose

Accurate and real-time prediction of the lung and lung tumor deformation during respiration are important considerations when performing a peripheral biopsy procedure. However, most existing work focused on offline whole lung simulation using 4D image data, which is not applicable in real-time image-guided biopsy with limited image resources. In this paper, we propose a patient-specific biomechanical model based on the boundary element method (BEM) computed from CT images to estimate the respiration motion of local target lesion region, vessel tree and lung surface for the real-time biopsy guidance.

Methods

This approach applies pre-computation of various BEM parameters to facilitate the requirement for real-time lung motion simulation. The resulting boundary condition at end inspiratory phase is obtained using a nonparametric discrete registration with convex optimization, and the simulation of the internal tissue is achieved by applying a tetrahedron-based interpolation method depend on expert-determined feature points on the vessel tree model. A reference needle is tracked to update the simulated lung motion during biopsy guidance.

Results

We evaluate the model by applying it for respiratory motion estimations of ten patients. The average symmetric surface distance (ASSD) and the mean target registration error (TRE) are employed to evaluate the proposed model. Results reveal that it is possible to predict the lung motion with ASSD of \(1.9\pm 0.8\) mm and a mean TRE of \(2.5\pm 2.1\) mm at largest over the entire respiratory cycle. In the CT-/electromagnetic-guided biopsy experiment, the whole process was assisted by our BEM model and final puncture errors in two studies were 3.1 and 2.0 mm, respectively.

Conclusion

The experiment results reveal that both the accuracy of simulation and real-time performance meet the demands of clinical biopsy guidance.

Vorheriger Artikel Blood flow-induced physically based guidewire simulation for vascular intervention training

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Titel: BEM-based simulation of lung respiratory deformation for CT-guided biopsy
verfasst von: Dong Chen
Weisheng Chen
Lipeng Huang
Xuegang Feng
Terry Peters
Lixu Gu
Publikationsdatum: 10.05.2017
Verlag: Springer International Publishing
Erschienen in: International Journal of Computer Assisted Radiology and Surgery / Ausgabe 9/2017
Print ISSN: 1861-6410
Elektronische ISSN: 1861-6429
DOI: https://doi.org/10.1007/s11548-017-1603-8

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Abstract

Purpose

Methods

Results

Conclusion

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