nach oben

Erschienen in:

2022 | OriginalPaper | Buchkapitel

Cerebral Activation in Subjects with Developmental Coordination Disorder: A Pilot Study with PET Imaging

verfasst von : Marie Farmer, Bernard Echenne, M’hamed Bentourkia

Erschienen in: Bioinformatics and Biomedical Engineering

Verlag: Springer International Publishing

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config

KI-gestützte Suche

Aus

Abstract

Background: Developmental coordination disorder (DCD) is a neurodevelopmental disorder encountered in about 6% of children at school age. DCD mostly affects motor task automatization and it persists in adulthood. Several brain structures were supposed to be involved in DCD pathophysiology. Quantitative imaging techniques have the potential to investigate these connected brain regions associated with motor tasks. Methods: In the present work, we studied with 18F-fluorodeoxyglucose (18F-FDG) and positron emission tomography imaging (PET) brain metabolism in subjects with DCD versus control in resting state and during repetitive and standardized finger movements of the left non-dominant hand. We analyzed 42 brain structures in the right and left hemispheres and the data were statistically assessed by the Ward clustering approach to detect the activated/non-activated/deactivated brain regions. Results: The images obtained with PET clearly showed different uptake of 18F-FDG in subjects with DCD with respect to control subjects. The statistics showed less brain regions activated and more deactivated in subjects with DCD than in control. Among other differences, the right thalamus was activated in DCD subjects as both caudate nuclei were deactivated for a possible compensation for basal ganglia dysfunction or deficit. Conclusions: This first PET study of DCD found significant thalamus activation as previous studies on finger movement tasks comparing PET and fMRI in normal subjects. The Ward clustering in DCD images allowed to identify activated/non-activated/deactivated brain structures in subjects with DCD versus control.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 340 Zeitschriften

aus folgenden Fachgebieten:

Bauwesen + Immobilien
Business IT + Informatik
Finance + Banking
Management + Führung
Marketing + Vertrieb
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Vorheriges Kapitel Initial Prototype of Low-Cost Stool Monitoring System for Early Detection of Diseases

Nächstes Kapitel On the Use of Explainable Artificial Intelligence for the Differential Diagnosis of Pigmented Skin Lesions

Farmer, M., Echenne, B., Bentourkia, M.: Study of clinical characteristics in young subjects with developmental coordination disorder. Brain Dev. 38, 538–547 (2016). https://doi.org/10.1016/j.braindev.2015.12.010CrossRefPubMed

Kirby, A., Edwards, L., Sugden, D.: Emerging adulthood and developmental co-ordination disorder. J. Adult Dev. 18, 107–113 (2011). https://doi.org/10.1007/s10804-011-9123-1CrossRef

Nicolson, R.I., Fawcett, A.J.: Dyslexia, dysgraphia, procedural learning and the cerebellum. Cortex 47, 117–127 (2011). https://doi.org/10.1016/j.cortex.2009.08.016CrossRefPubMed

Schutter, D.J.L.G., Van Honk, J.: The cerebellum in emotion regulation: a repetitive transcranial magnetic stimulation study. Cerebellum 8, 28–34 (2009). https://doi.org/10.1007/s12311-008-0056-6CrossRefPubMed

Gomez, A., Sirigu, A.: Developmental coordination disorder: core sensori-motor deficits, neurobiology and etiology. Neuropsychologia 79, 272–287 (2015). https://doi.org/10.1016/j.neuropsychologia.2015.09.032CrossRefPubMed

Licari, M.K., et al.: Cortical functioning in children with developmental coordination disorder: a motor overflow study. Exp. Brain Res. 233(6), 1703–1710 (2015). https://doi.org/10.1007/s00221-015-4243-7CrossRefPubMed

Catalan, M.J., Honda, M., Weeks, R.A., Cohen, L.G., Hallett, M.: The functional neuroanatomy of simple and complex sequential finger movements: a PET study. Brain 121, 253–264 (1998). https://doi.org/10.1093/brain/121.2.253CrossRefPubMed

Erdler, M., et al.: Dissociation of supplementary motor area and primary motor cortex in human subjects when comparing index and little finger movements with functional magnetic resonance imaging. Neurosci. Lett. 313, 5–8 (2001). https://doi.org/10.1016/S0304-3940(01)02167-XCrossRefPubMed

François-Brosseau, F.E., Martinu, K., Strafella, A.P., Petrides, M., Simard, F., Monchi, O.: Basal ganglia and frontal involvement in self-generated and externally-triggered finger movements in the dominant and non-dominant hand. Eur. J. Neurosci. 29, 1277–1286 (2009). https://doi.org/10.1111/j.1460-9568.2009.06671.xCrossRefPubMed

10.

Blouin, J.S., Bard, C., Paillard, J.: Contribution of the cerebellum to self-initiated synchronized movements: a PET study. Exp. Brain Res. 155, 63–68 (2004). https://doi.org/10.1007/s00221-003-1709-9CrossRefPubMed

11.

Thickbroom, G.W., Byrnes, M.L., Mastaglia, F.L.: Dual representation of the hand in the cerebellum: activation with voluntary and passive finger movement. Neuroimage 18, 670–674 (2003). https://doi.org/10.1016/S1053-8119(02)00055-1CrossRefPubMed

12.

Zeng, L., Chen, H., Ouyang, L., Yao, D., Gao, J.H.: Quantitative analysis of asymmetrical cortical activity in motor areas during sequential finger movement. Magn. Reson. Imaging. 25, 1370–1375 (2007). https://doi.org/10.1016/j.mri.2007.03.024CrossRefPubMed

13.

Wu, X., et al.: Ipsilateral brain deactivation specific to the nondominant hand during simple finger movements. NeuroReport 19, 483–486 (2008). https://doi.org/10.1097/WNR.0b013e3282f6030bCrossRefPubMed

14.

Brown-Lum, M., Zwicker, J.G.: Brain imaging increases our understanding of developmental coordination disorder: a review of literature and future directions. Curr. Dev. Disord. Rep. 2(2), 131–140 (2015). https://doi.org/10.1007/s40474-015-0046-6CrossRef

15.

Bo, J., Lee, C.M.: Motor skill learning in children with Developmental Coordination Disorder, Res. Dev. Disabil. 34, 2047–2055 (2013). https://doi.org/10.1016/j.ridd.2013.03.012

16.

Kirby, A., Edwards, L., Sugden, D., Rosenblum, S.: The development and standardization of the adult developmental co-ordination disorders/Dyspraxia checklist (ADC). Res. Dev. Disabil. 31, 131–139 (2010). https://doi.org/10.1016/j.ridd.2009.08.010CrossRefPubMed

17.

Oldfield, R.C.: The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9, 97–113 (1971). https://doi.org/10.1016/0028-3932(71)90067-4CrossRefPubMed

18.

Thie, J.A.: Understanding the standardized uptake value, its methods, and implications for usage. J. Nucl. Med. 45, 1431–1434 (2004)PubMed

19.

Verbraecken, J., Van De Heyning, P., De Backer, W., Van Gaal, L.: Body surface area in normal-weight, overweight, and obese adults. A comparison study. Metabolism 281, E586–E591 (2006). https://doi.org/10.1016/j.metabol.2005.11.004CrossRef

20.

Albaret, J.M., Chaix, Y.: Neurobiological bases and neurophysiological correlates of developmental coordination disorders. Neurophysiol. Clin. 42, 11–17 (2012). https://doi.org/10.1016/j.neucli.2011.07.001CrossRefPubMed

21.

Fassbender, C., et al.: A topography of executive functions and their interactions revealed by functional magnetic resonance imaging. Cogn. Brain Res. 20, 132–143 (2004). https://doi.org/10.1016/j.cogbrainres.2004.02.007CrossRef

22.

Zwicker, J.G., Missiuna, C., Harris, S.R., Boyd, L.A.: Brain activation of children with developmental coordination disorder is different than peers. Pediatrics 126, 678–686 (2010). https://doi.org/10.1542/peds.2010-0059CrossRef

23.

Querne, L., et al.: Dysfunction of the attentional brain network in children with Developmental Coordination Disorder: a fMRI study. Brain Res. 1244, 89–102 (2008). https://doi.org/10.1016/j.brainres.2008.07.066CrossRefPubMed

24.

Allison, J.D., Meador, K.J., Loring, D.W., Figueroa, R.E., Wright, J.C.: Functional MRI cerebral activation and deactivation during finger movement. Neurology 54, 135 (2000). https://doi.org/10.1212/wnl.54.1.135CrossRefPubMed

Titel: Cerebral Activation in Subjects with Developmental Coordination Disorder: A Pilot Study with PET Imaging
verfasst von: Marie Farmer
Bernard Echenne
M’hamed Bentourkia
Verlag: Springer International Publishing
Buch: Bioinformatics and Biomedical Engineering
Print ISBN: 978-3-031-07703-6

Electronic ISBN: 978-3-031-07704-3

Copyright-Jahr: 2022
DOI: https://doi.org/10.1007/978-3-031-07704-3_25

Springer Professional

Abstract

Bitte loggen Sie sich ein, um Zugang zu Ihrer Lizenz zu erhalten.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Technik"

Springer Professional "Wirtschaft"

Premium Partner