nach oben

Quality of Life Research

Erschienen in:

28.12.2023 | Review

Chronic cough: more than just a persistent cough: a systematic literature review to understand the impact of chronic cough on quality of life

verfasst von: Vishal Bali, Ada Adriano, Aidan Byrne, Katherine G. Akers, Andrew Frederickson, Jonathan Schelfhout

Erschienen in: Quality of Life Research | Ausgabe 4/2024

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config

KI-gestützte Suche

Aus

Abstract

Purpose

Chronic cough (CC), defined as a cough persisting ≥ 8 weeks, can have a substantial negative impact on health-related quality of life (HRQoL). This is exacerbated by challenges with timely diagnosis and a lack of approved therapies. A systematic literature review (SLR) was conducted to identify evidence on HRQoL and health state utility values associated with refractory CC or unexplained CC.

Methods

Electronic database searches were supplemented with searches of conference proceedings and health technology assessment body websites. Two independent reviewers assessed all citations for inclusion based on predefined inclusion/exclusion criteria. Key inclusion criteria were patient populations with CC and reporting of patient-reported outcomes or utilities using generic or disease-specific measures.

Results

Following screening, 65 studies were identified for inclusion in the SLR. Of these, 23 studies assessed HRQoL among patients with CC who were not treated or treated with unspecified interventions, and 42 studies in patients who were treated with specified interventions. The studies indicated a substantial decrement to HRQoL as a result of CC, characterized by generic and disease-specific patient-reported outcome measures. HRQoL was impacted across multiple domains, including physical, psychological, and social functioning. The studies also demonstrated the potential for treatments to have a significant positive impact on HRQoL.

Conclusions

CC can substantially affect HRQoL in patients, across physical, psychological, and social domains. Although treatments can improve HRQoL in these patients, the available evidence is limited. There remains an unmet need for approved pharmacological treatments to alleviate CC and improve HRQoL for these patients.

Vorheriger Artikel Biopsychosocial factors of quality of life in individuals with moderate to severe traumatic brain injury: a scoping review

Nächster Artikel Do physical fitness and cognitive function mediate the relationship between basic activities of daily living and quality of life in older adults with dementia?

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 340 Zeitschriften

aus folgenden Fachgebieten:

Bauwesen + Immobilien
Business IT + Informatik
Finance + Banking
Management + Führung
Marketing + Vertrieb
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Nur mit Berechtigung zugänglich

Irwin, R. S., et al. (2014). Overview of the management of cough: CHEST guideline and expert panel report. Chest, 146(4), 885–889.CrossRefPubMedPubMedCentral

Song, W. J., et al. (2015). The global epidemiology of chronic cough in adults: A systematic review and meta-analysis. European Respiratory Journal, 45(5), 1479–1481. https://doi.org/10.1183/09031936.00218714CrossRefPubMed

Morice, A. H., et al. (2020). ERS guidelines on the diagnosis and treatment of chronic cough in adults and children. European Respiratory Journal. https://doi.org/10.1183/13993003.01136-2019CrossRefPubMed

Irwin, R. S., et al. (2006). Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines. Chest, 129(1 Suppl), 1S-23S. https://doi.org/10.1378/chest.129.1_suppl.1S. in Eng.CrossRefPubMed

Morice, A. H., McGarvey, L., Pavord, I., & British, G. (2006). Thoracic Society cough guideline, "recommendations for the management of cough in adults. Thorax, 61(1), i1-24. https://doi.org/10.1136/thx.2006.065144CrossRefPubMedPubMedCentral

Meltzer, E. O., et al. (2021). Prevalence and burden of chronic cough in the United States. The Journal of Allergy and Clinical Immunology: In Practice, 9(11), 4037-4044.e2. https://doi.org/10.1016/j.jaip.2021.07.022CrossRefPubMed

Gibson, P., Wang, G., McGarvey, L., Vertigan, A. E., Altman, K. W., & Birring, S. S. (2016). Treatment of unexplained chronic cough. Chest Journal, 149(1), 27–44.CrossRef

Gibson, P. G., & Vertigan, A. E. (2015). Management of chronic refractory cough. BMJ, 351, h5590. https://doi.org/10.1136/bmj.h5590CrossRefPubMed

Morice, A. H. (2010). The cough hypersensitivity syndrome: A novel paradigm for understanding cough. Lung, 188(1), S87-90. https://doi.org/10.1007/s00408-009-9185-z. in Eng.CrossRefPubMed

10.

Young, E. C., & Smith, J. A. (2010). Quality of life in patients with chronic cough. Therapeutic Advances in Respiratory Disease, 4(1), 49–55. https://doi.org/10.1177/1753465809358249. in Eng.CrossRefPubMed

11.

CADTH. "Strings Attached: CADTH’s Database Search Filters." https://www.cadth.ca/strings-attached-cadths-database-search-filters Accessed

12.

McGarvey, L., et al. (2020). Late breaking abstract—Two phase 3 randomized Clinical trials of gefapixant, a P2X3 receptor antagonist, in refractory or unexplained chronic cough (COUGH-1 and COUGH-2). European Respiratory Journal, 56(64), 3800. https://doi.org/10.1183/13993003.congress-2020.3800CrossRef

13.

NCT03449134. A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-027). https://clinicaltrials.gov/study/NCT03449134 Accessed

14.

NCT03449147. Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-030). https://clinicaltrials.gov/study/NCT03449147 Accessed

15.

Gibson, P., et al. (2016). Treatment of unexplained chronic cough: CHEST guideline and expert panel report. Chest, 149(1), 27–44. https://doi.org/10.1378/chest.15-1496CrossRefPubMedPubMedCentral

16.

Birring, S. S. (2011). Controversies in the evaluation and management of chronic cough. American Journal of Respiratory and Critical Care Medicine, 183(6), 708–715. https://doi.org/10.1164/rccm.201007-1017CI. in Eng.CrossRefPubMed

17.

Dicpinigaitis, P. V. (2011). Cough: An unmet clinical need. British Journal of Pharmacology, 163(1), 116–124. https://doi.org/10.1111/j.1476-5381.2010.01198.x. in Eng.CrossRefPubMedPubMedCentral

18.

Efficace, F., et al. (2003). Beyond the development of health-related quality-of-life (HRQOL) measures: A checklist for evaluating HRQOL outcomes in cancer clinical trials–does HRQOL evaluation in prostate cancer research inform clinical decision making? Journal of Clinical Oncology, 21(18), 3502–3511. https://doi.org/10.1200/JCO.2003.12.121CrossRefPubMed

19.

Raj, A. A., Pavord, D. I., & Birring, S. S. (2009). Clinical cough IV:What is the minimal important difference for the Leicester Cough Questionnaire? Handbook of Experimental Pharmacology, 187, 311–320. https://doi.org/10.1007/978-3-540-79842-2_16. in Eng.CrossRef

20.

Singapuri, A., McKenna, S., & Brightling, C. E. (2008). The utility of the mannitol challenge in the assessment of chronic cough: a pilot study. Cough. https://doi.org/10.1186/1745-9974-4-10CrossRefPubMedPubMedCentral

21.

Hilton, E., Marsden, P., Thurston, A., Kennedy, S., Decalmer, S., & Smith, J. A. (2015). Clinical features of the urge-to-cough in patients with chronic cough. Respiratory Medicine, 109(6), 701–707. https://doi.org/10.1016/j.rmed.2015.03.011. in Eng.CrossRefPubMed

22.

Kelsall, A., Decalmer, S., McGuinness, K., Woodcock, A., & Smith, J. A. (2009). Sex differences and predictors of objective cough frequency in chronic cough. Thorax, 64(5), 393–398. https://doi.org/10.1136/thx.2008.106237. in Eng.CrossRefPubMed

23.

Kelsall, A., et al. (2008). How to quantify coughing: Correlations with quality of life in chronic cough. European Respiratory Journal, 32(1), 175–179. https://doi.org/10.1183/09031936.00101307. in Eng.CrossRefPubMed

24.

Kelsall, A., Houghton, L. A., Jones, H., Decalmer, S., McGuinness, K., & Smith, J. A. (2011). A novel approach to studying the relationship between subjective and objective measures of cough. Chest, 139(3), 569–575. https://doi.org/10.1378/chest.10-0438. in Eng.CrossRefPubMed

25.

O’Connell, F., Thomas, V. E., Pride, N. B., & Fuller, R. W. (1994). Capsaicin cough sensitivity decreases with successful treatment of chronic cough. American journal of respiratory and critical care medicine, 150(2), 374–380. https://doi.org/10.1164/ajrccm.150.2.8049818. in Eng.CrossRefPubMed

26.

Decalmer, S. C., Webster, D., Kelsall, A. A., McGuinness, K., Woodcock, A. A., & Smith, J. A. (2007). Chronic cough: How do cough reflex sensitivity and subjective assessments correlate with objective cough counts during ambulatory monitoring? Thorax, 62(4), 329–334. https://doi.org/10.1136/thx.2006.067413. in Eng.CrossRefPubMed

27.

Faruqi, S., Thompson, R., Wright, C., Sheedy, W., & Morice, A. H. (2011). Quantifying chronic cough: Objective versus subjective measurements. Respirology (Carlton, Vic.), 16(2), 314–20. https://doi.org/10.1111/j.1440-1843.2010.01893.x. in Eng.CrossRefPubMed

28.

French, C. L., Crawford, S. L., Bova, C., & Irwin, R. S. (2017). Change in psychological, physiological, and situational factors in adults after treatment of chronic cough. Chest, 152(3), 547–562. https://doi.org/10.1016/j.chest.2017.06.024. in Eng.CrossRefPubMed

29.

French, C. T., Fletcher, K. E., & Irwin, R. S. (2004). Gender differences in health-related quality of life in patients complaining of chronic cough. Chest, 125(2), 482–488. https://doi.org/10.1378/chest.125.2.482. in Eng.CrossRefPubMed

30.

French, C. T., Irwin, R. S., Fletcher, K. E., & Adams, T. M. (2002). Evaluation of a cough-specific quality-of-life questionnaire. Chest, 121(4), 1123–1131. https://doi.org/10.1378/chest.121.4.1123. in Eng.CrossRefPubMed

31.

Levine, B. M. (2008). Systematic evaluation and treatment of chronic cough in a community setting. Allergy and Asthma Proceedings, 29(3), 336–42. https://doi.org/10.2500/aap.2008.29.3122. in Eng.CrossRefPubMed

32.

Meltzer, E., et al. (2019). P351 chronic cough in America: Prevalence and patient characteristics. Annals of Allergy, Asthma & Immunology, 123(5), S54. https://doi.org/10.1016/j.anai.2019.08.330CrossRef

33.

Won, H. K., et al. (2019). Cough-related laryngeal sensations and triggers in adults with chronic cough: Symptom profile and impact. Allergy, Asthma & Immunology Research, 11(5), 622–631. https://doi.org/10.4168/aair.2019.11.5.622. in Eng.CrossRef

34.

Won, H. K., et al. (2020). Impact of chronic cough on health-related quality of life in the Korean adult general population: The Korean National Health and Nutrition Examination Survey 2010–2016. Allergy, Asthma & Immunology Research, 12(6), 964–979. https://doi.org/10.4168/aair.2020.12.6.964. in Eng.CrossRef

35.

Fukuhara, A., et al. (2020). Clinical characteristics of cough frequency patterns in patients with and without asthma. The Journal of Allergy and Clinical Immunology. In Practice, 8(2), 654–661. https://doi.org/10.1016/j.jaip.2019.08.053. in Eng.CrossRefPubMed

36.

Kanemitsu, Y., et al. (2019). Clinical impact of gastroesophageal reflux disease in patients with subacute/chronic cough. Allergology International : Official Journal of the Japanese Society of Allergology, 68(4), 478–485. https://doi.org/10.1016/j.alit.2019.04.011. in Eng.CrossRefPubMed

37.

Braido, F., et al. (2006). Chronic cough and QoL in allergic and respiratory diseases measured by a new specific validated tool-CCIQ. Journal of Investigational Allergology & Clinical Immunology, 16(2), 110–116. in Eng.

38.

Kalpaklioglu, A. F., Kara, T., Kurtipek, E., Kocyigit, P., Ekici, A., & Ekici, M. (2005). Evaluation and impact of chronic cough: Comparison of specific vs generic quality-of-life questionnaires. Annals of Allergy, Asthma & Immunology : Official publication of the American College of Allergy, Asthma, & Immunology, 94(5), 581–585. https://doi.org/10.1016/s1081-1206(10)61137-4. in Eng.CrossRef

39.

Koskela, H. O., Lätti, A. M., & Purokivi, M. K. (2017). Long-term prognosis of chronic cough: A prospective, observational cohort study. BMC Pulmonary Medicine, 17(1), 146–146. https://doi.org/10.1186/s12890-017-0496-1. in Eng.CrossRefPubMedPubMedCentral

40.

Ma, W., Yu, L., Wang, Y., Li, X., Lü, H., & Qiu, Z. (2009). Changes in health-related quality of life and clinical implications in Chinese patients with chronic cough. Cough (London, England), 5, 7–7. https://doi.org/10.1186/1745-9974-5-7. in Eng.CrossRefPubMed

41.

Polley, L., et al. (2008). Impact of cough across different chronic respiratory diseases: Comparison of two cough-specific health-related quality of life questionnaires. Chest, 134(2), 295–302. https://doi.org/10.1378/chest.07-0141. in Eng.CrossRefPubMed

42.

Birring, S., Muccino, D., Bacci, E. D., Vernon, M. K., & Nguyen, A. M. (2019). Defining minimal clinically important differences (MCID) on the leicester cough questionnaire (LCQ): Analyses of a phase 2 randomized controlled trial in chronic cough. Journal of Allergy and Clinical Immunology, 143(2), AB52. https://doi.org/10.1016/j.jaci.2018.12.158CrossRef

43.

Lechtzin, N., Hilliard, M. E., & Horton, M. R. (2013). Validation of the cough quality-of-life questionnaire in patients with idiopathic pulmonary fibrosis. Chest, 143(6), 1745–1749. https://doi.org/10.1378/chest.12-2870. in Eng.CrossRefPubMedPubMedCentral

44.

Abdulqawi, R., et al. (2015). P2X3 receptor antagonist (AF-219) in refractory chronic cough: A randomised, double-blind, placebo-controlled phase 2 study. Lancet, 385(9974), 1198–1205. https://doi.org/10.1016/S0140-6736(14)61255-1CrossRefPubMed

45.

Morice, A. H., et al. (2019). The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: a randomised placebo-controlled study. European Respiratory Journal. https://doi.org/10.1183/13993003.00439-2019CrossRefPubMed

46.

Smith, J. A., et al. (2020). Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: A randomised, double-blind, controlled, parallel-group, phase 2b trial. The Lancet Respiratory Medicine, 8(8), 775–785. https://doi.org/10.1016/S2213-2600(19)30471-0CrossRefPubMed

47.

Smith, J. A., et al. (2020). Gefapixant in two randomised dose-escalation studies in chronic cough. European Respiratory Journal. https://doi.org/10.1183/13993003.01615-2019. in Eng.CrossRefPubMed

48.

Bowen, A. J., et al. (2018). Short- and long-term effects of neuromodulators for unexplained chronic cough. Otolaryngology–Head and Neck Surgery: Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 159(3), 508–515. https://doi.org/10.1177/0194599818768517. in Eng.CrossRefPubMed

49.

Dong, R., et al. (2019). Randomised clinical trial: Gabapentin vs baclofen in the treatment of suspected refractory gastro-oesophageal reflux-induced chronic cough. Alimentary Pharmacology & Therapeutics, 49(6), 714–722. https://doi.org/10.1111/apt.15169. in Eng.CrossRef

50.

Ryan, N. M., Birring, S. S., & Gibson, P. G. (2012). Gabapentin for refractory chronic cough: A randomised, double-blind, placebo-controlled trial. Lancet, 380(9853), 1583–1589. https://doi.org/10.1016/s0140-6736(12)60776-4. in Eng.CrossRefPubMed

51.

Van de Kerkhove, C., Goeminne, P. C., Van Bleyenbergh, P., & Dupont, L. J. (2012). A cohort description and analysis of the effect of gabapentin on idiopathic cough. Cough (London, England), 8(1), 9–9. https://doi.org/10.1186/1745-9974-8-9. in Eng.CrossRefPubMed

52.

Vertigan, A. E., Kapela, S. L., Ryan, N. M., Birring, S. S., McElduff, P., & Gibson, P. G. (2016). Pregabalin and speech pathology combination therapy for refractory chronic cough: A randomized controlled trial. Chest, 149(3), 639–648. https://doi.org/10.1378/chest.15-1271. in Eng.CrossRefPubMed

53.

Morice, A. H., et al. (2007). Opiate therapy in chronic cough. American Journal of Respiratory and Critical Care Medicine, 175(4), 312–315. https://doi.org/10.1164/rccm.200607-892OC. in Eng.CrossRefPubMed

54.

Mazzone, S. B., & McGarvey, L. (2021). Mechanisms and rationale for targeted therapies in refractory and unexplained chronic cough,. Clinical Pharmacology & Therapeutics, 109(3), 619–636. https://doi.org/10.1002/cpt.2003CrossRef

55.

Roe, N. A., Lundy, F. T., Litherland, G. J., & McGarvey, L. P. A. (2019). Therapeutic targets for the treatment of chronic cough. Current Otorhinolaryngology Reports, 7(2), 116–128. https://doi.org/10.1007/s40136-019-00239-9CrossRef

56.

I. Merck & Co. Merck Receives Positive European Union CHMP Opinion for Gefapixant. Retrieved August 10, 2023, from https://www.merck.com/news/merck-receives-positive-european-union-chmp-opinion-for-gefapixant/

57.

Medthority. MHLW (Japan) approves Lyfnua (gefapixant) to treat refractory or unexplained cough. Retrieved August 10, 2023 https://www.medthority.com/news/2022/1/mhlw-japan-approves-lyfnua-gefapixant-to-treat-refractory-or-unexplained-cough.--merck-inc/

58.

Kubo, T., et al. (2021). Disease burden and quality of life of patients with chronic cough in Japan: A population-based cross-sectional survey. BMJ Open Respiratory Research, 8(1), e000764. https://doi.org/10.1136/bmjresp-2020-000764CrossRefPubMedPubMedCentral

59.

Dasgupta, N., Beletsky, L., & Ciccarone, D. (2018). Opioid crisis: No Easy fix to its social and economic determinants. American Journal of Public Health, 108(2), 182–186. https://doi.org/10.2105/AJPH.2017.304187. in Eng.CrossRefPubMedPubMedCentral

60.

Morice, A., Dicpinigaitis, P., McGarvey, L., & Birring, S. S. (2021). Chronic cough: New insights and future prospects. European Respiratory Review. https://doi.org/10.1183/16000617.0127-2021. in Eng.CrossRefPubMedPubMedCentral

61.

Glanville, J., Kaunelis, D., & Mensinkai, S. (2009). How well do search filters perform in identifying economic evaluations in MEDLINE and EMBASE. International Journal of Technology Assessment in Health Care, 25(4), 522–529.CrossRefPubMed

62.

Centers for Disease Control and Prevention. International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM). Retrieved June 16, 2022 from https://www.cdc.gov/nchs/icd/icd-10-cm.htm

Titel: Chronic cough: more than just a persistent cough: a systematic literature review to understand the impact of chronic cough on quality of life
verfasst von: Vishal Bali
Ada Adriano
Aidan Byrne
Katherine G. Akers
Andrew Frederickson
Jonathan Schelfhout
Publikationsdatum: 28.12.2023
Verlag: Springer International Publishing
Erschienen in: Quality of Life Research / Ausgabe 4/2024
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-023-03556-1

Springer Professional

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu Ihrer Lizenz zu erhalten.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Wirtschaft"

Weitere Artikel der Ausgabe 4/2024

Estimating anchor-based minimal important change using longitudinal confirmatory factor analysis

Life’s Essential 8 in relation to self-rated health and health-related quality of life in a large population-based sample: the SCAPIS project

Assessing the interchangeability of linked scores in multivariable statistical analyses

Individual differences in the long-term impact of the pandemic: moderators of COVID-related hardship, worry, and social support

Dynamic changes and lifetime effect of functional disability profiles for stroke patients: real-world evidence from South Korea

Psychosocial predictors of quality of life among women living with HIV/AIDS: a cross-sectional study in a VCT centre in Shiraz, Iran

Premium Partner