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Erschienen in:

2019 | OriginalPaper | Buchkapitel

8. Computational Modelling of Collagen Hydrogel

verfasst von : Andre Castro, Maryam Shariatzadeh, Damien Lacroix

Erschienen in: Multiscale Mechanobiology in Tissue Engineering

Verlag: Springer Singapore

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Abstract

Collagen is one of the most used biomaterials in tissue engineering applications. It is abundant in biological tissues, namely, constituting approximately 30% of all musculoskeletal tissues, through the presence in the extracellular matrix. Along the years, several works tried to characterize this biomaterial, as isolated fibres or as part of hydrogels, but the fragility of this material has been deferring its full characterization. This chapter presents an experimental and numerical characterization of a highly hydrated collagen hydrogel, with 0.20% of collagen concentration. The experimental data obtained through rheology experiments with three hydrogel samples was complemented with numerical simulation through finite element techniques. This framework was complemented with literature data, resulting on a set of biomechanical parameters that can describe the hydrogel behaviour, namely, a shear modulus of 0.023 kPa and a bulk modulus of 0.769 kPa, corresponding to a Poisson’s ratio of 0.485. The ultimate aim for this work is to contribute for the determination of the load transfer mechanisms through a collagen medium, i.e. to understand the contribution of collagen on the mechanical stimuli that affect cell behaviour on scaffold cell seeding.

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Vorheriges Kapitel Collagen Gel Cell Encapsulation to Study the Effect of Fluid Flow on Mechanotransduction

Nächstes Kapitel Mechanical Load Transfer at the Cellular Level

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Titel: Computational Modelling of Collagen Hydrogel
verfasst von: Andre Castro
Maryam Shariatzadeh
Damien Lacroix
Verlag: Springer Singapore
Buch: Multiscale Mechanobiology in Tissue Engineering
Print ISBN: 978-981-10-8074-6

Electronic ISBN: 978-981-10-8075-3

Copyright-Jahr: 2019
DOI: https://doi.org/10.1007/978-981-10-8075-3_8

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