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Journal of Nanoparticle Research

Erschienen in:

01.07.2017 | Research Paper

Control of in vivo disposition and immunogenicity of polymeric micelles by adjusting poly(sarcosine) chain lengths on surface

verfasst von: Kensuke Kurihara, Motoki Ueda, Isao Hara, Eiichi Ozeki, Kaori Togashi, Shunsaku Kimura

Erschienen in: Journal of Nanoparticle Research | Ausgabe 7/2017

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Abstract

Four kinds of A₃B-type amphiphilic polydepsipeptides, (poly(sarcosine))₃-b-poly(l-lactic acid) (the degree of polymerization of poly(sarcosine) are 10, 33, 55, and 85; S10 ₃, S33 ₃, S55 ₃, and S85 ₃) were synthesized to prepare core-shell type polymeric micelles. Their in vivo dispositions and stimulations to trigger immune system to produce IgM upon multiple administrations to mice were examined. With increasing poly(sarcosine) chain lengths, the hydrophilic shell became thicker and the surface density at the most outer surface decreased on the basis of dynamic and static light scattering measurements. These two physical elements of polymeric micelles elicited opposite effects on the immune response in light of the chain length therefore to show an optimized poly(sarcosine) chain length existing between 33mer and 55mer to suppress the accelerated blood clearance phenomenon associated with polymeric micelles.

Vorheriger Artikel Facial synthesis of carbon-coated ZnFe2O4/graphene and their enhanced lithium storage properties

Nächster Artikel Modified WO3 nanorod with Pt nanoparticle as retrievable materials in catalytic and photocatalytic aerobic oxidation of alcohols

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Titel: Control of in vivo disposition and immunogenicity of polymeric micelles by adjusting poly(sarcosine) chain lengths on surface
verfasst von: Kensuke Kurihara
Motoki Ueda
Isao Hara
Eiichi Ozeki
Kaori Togashi
Shunsaku Kimura
Publikationsdatum: 01.07.2017
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 7/2017
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-017-3936-1

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