Skip to main content

2016 | OriginalPaper | Buchkapitel

11. Demenzielle Erkrankungen bei Menschen mit Down-Syndrom

verfasst von : Dr. Antonia Coppus, Hildegard Telbis-Kankainen

Erschienen in: Lebensqualität im Alter

Verlag: Springer Fachmedien Wiesbaden

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Zusammenfassung

Die Lebenserwartung von Menschen mit DS hat in den letzten Jahrzehnten stark zugenommen. Ungefähr 80 % der Menschen mit DS werden beim Älterwerden eine Demenz entwickeln. Somit bildet diese Gruppe die Population mit dem höchsten genetischen Risiko für Demenz. Um diese Diagnose zu stellen, gehört eine korrekte Handhabung der Diagnostik mit einer multidisziplinären Annährung dazu. Andere mögliche Ursachen eines Rückgangs des Funktionsniveaus müssen ausgeschlossen werden. Eine medizinische Behandlung der Demenz ist jedoch nicht möglich. Die Behandlung besteht aus psychosozialen Interventionen, wobei Ko-Morbidität wie beispielsweise Epilepsie auch beachtet werden müssen. Nach der Diagnosestellung Demenz muss man für eine optimale Lebensqualität und eine gute palliative Begleitung sorgen.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Literatur
Zurück zum Zitat APA. (2000). American Psychiatric Association: Diagnostic and statistical manual of mental disorders (4. überarb. Aufl.) (DSM-IV-TR) APA. Neu Dehli: Jaypee Brothers Medical Publisher. APA. (2000). American Psychiatric Association: Diagnostic and statistical manual of mental disorders (4. überarb. Aufl.) (DSM-IV-TR) APA. Neu Dehli: Jaypee Brothers Medical Publisher.
Zurück zum Zitat Aylward, E. H., Burt, D. B., Thorpe, L. U., Lai, F., & Dalton, A. (1997). Diagnosis of dementia in individuals with intellectual disability. Journal of Intellectual Disability Research, 41(2), 152–164.CrossRef Aylward, E. H., Burt, D. B., Thorpe, L. U., Lai, F., & Dalton, A. (1997). Diagnosis of dementia in individuals with intellectual disability. Journal of Intellectual Disability Research, 41(2), 152–164.CrossRef
Zurück zum Zitat Bittles, A. H., Bower, C., Hussain, R., & Glasson, E. J. (2007). The four ages of Down syndrome. European Journal of Public Health, 17(2), 221–225.CrossRef Bittles, A. H., Bower, C., Hussain, R., & Glasson, E. J. (2007). The four ages of Down syndrome. European Journal of Public Health, 17(2), 221–225.CrossRef
Zurück zum Zitat Burt, D. B., & Aylward, E. H. (2000). Test battery for the diagnosis of dementia in individuals with intellectual disability. Working Group for the Establishment of Criteria for the Diagnosis of Dementia in Individuals with Intellectual Disability. Journal of Intellectual Disability Research, 44(2), 175–180.CrossRef Burt, D. B., & Aylward, E. H. (2000). Test battery for the diagnosis of dementia in individuals with intellectual disability. Working Group for the Establishment of Criteria for the Diagnosis of Dementia in Individuals with Intellectual Disability. Journal of Intellectual Disability Research, 44(2), 175–180.CrossRef
Zurück zum Zitat Cohen, S. I., Linse, S., Luheshi, L. M., Hellstrand, E., White, D. A., Rajah, L., Otzen, D. E., Vendruscolo, M., Dobson, C. M., & Knowles, T. P. (2013). Proliferation of amyloid-beta42 aggregates occurs through a secondary nucleation mechanism. Proceedings of the National Academy of Sciences of the United States of America, 110(24), 9758–9763.CrossRef Cohen, S. I., Linse, S., Luheshi, L. M., Hellstrand, E., White, D. A., Rajah, L., Otzen, D. E., Vendruscolo, M., Dobson, C. M., & Knowles, T. P. (2013). Proliferation of amyloid-beta42 aggregates occurs through a secondary nucleation mechanism. Proceedings of the National Academy of Sciences of the United States of America, 110(24), 9758–9763.CrossRef
Zurück zum Zitat Cooper, S. A., Melville, C. A., & Einfeld, S. L. (2003). Psychiatric diagnosis, intellectual disabilities and Diagnostic Criteria for Psychiatric Disorders for Use with Adults with Learning Disabilities/Mental Retardation (DC-LD). Journal of Intellectual Disability Research, 47(1), 3–15.CrossRef Cooper, S. A., Melville, C. A., & Einfeld, S. L. (2003). Psychiatric diagnosis, intellectual disabilities and Diagnostic Criteria for Psychiatric Disorders for Use with Adults with Learning Disabilities/Mental Retardation (DC-LD). Journal of Intellectual Disability Research, 47(1), 3–15.CrossRef
Zurück zum Zitat Coppus, A. M. W. (2015). Dementia and Mortality in Down syndrome, results from a follow-up study. Coppus, A. M. W. (2015). Dementia and Mortality in Down syndrome, results from a follow-up study.
Zurück zum Zitat Coppus, A., Evenhuis, H., Verberne, G. J., Visser, F., van Gool, P., Eikelenboom, P., & van Duijin, C. (2006). Dementia and mortality in persons with Down’s syndrome. Journal of Intellectual Disability Research, 50(10), 768–777.CrossRef Coppus, A., Evenhuis, H., Verberne, G. J., Visser, F., van Gool, P., Eikelenboom, P., & van Duijin, C. (2006). Dementia and mortality in persons with Down’s syndrome. Journal of Intellectual Disability Research, 50(10), 768–777.CrossRef
Zurück zum Zitat Coppus, A. M., Evenhuis, H. M., Verberne, G. J., Visser, F. E., Arias-Vasquez, A., Sayed-Tabatabaei, F. A., Vergeer-Drop, J., Eikelenboom, P., van Gool, W. A., & van Duijn, C. M. (2008a). The impact of apolipoprotein E on dementia in persons with Down’s syndrome. Neurobiology of Aging, 29(6), 828–835.CrossRef Coppus, A. M., Evenhuis, H. M., Verberne, G. J., Visser, F. E., Arias-Vasquez, A., Sayed-Tabatabaei, F. A., Vergeer-Drop, J., Eikelenboom, P., van Gool, W. A., & van Duijn, C. M. (2008a). The impact of apolipoprotein E on dementia in persons with Down’s syndrome. Neurobiology of Aging, 29(6), 828–835.CrossRef
Zurück zum Zitat Coppus, A. M., Evenhuis, H. M., Verberne, G. J., Visser, F. E., Oostra, B. A., Eikelenboom, P., van Gool, W. A., Janssens, A. C., & van Duijn, C. M. (2008b). Survival in elderly persons with Down syndrome. Journal of the American Geriatrics Society, 56(12), 2311–2316.CrossRef Coppus, A. M., Evenhuis, H. M., Verberne, G. J., Visser, F. E., Oostra, B. A., Eikelenboom, P., van Gool, W. A., Janssens, A. C., & van Duijn, C. M. (2008b). Survival in elderly persons with Down syndrome. Journal of the American Geriatrics Society, 56(12), 2311–2316.CrossRef
Zurück zum Zitat Coppus, A. M., Fekkes, D., Verhoeven, W. M., Evenhuis, H. M., & van Duijn, C. M. (2009). Neopterin and the risk of dementia in persons with Down syndrome. Neuroscience Letters, 458(2), 60–64.CrossRef Coppus, A. M., Fekkes, D., Verhoeven, W. M., Evenhuis, H. M., & van Duijn, C. M. (2009). Neopterin and the risk of dementia in persons with Down syndrome. Neuroscience Letters, 458(2), 60–64.CrossRef
Zurück zum Zitat Coppus, A. M., Schuur, M., Vergeer, J., Janssens, A. C., Oostra, B. A., Verbeek, M. M., & van Duijn, C. M. (2012). Plasma beta amyloid and the risk of Alzheimer’s disease in Down syndrome. Neurobiology of Aging, 33(9), 1988–1994.CrossRef Coppus, A. M., Schuur, M., Vergeer, J., Janssens, A. C., Oostra, B. A., Verbeek, M. M., & van Duijn, C. M. (2012). Plasma beta amyloid and the risk of Alzheimer’s disease in Down syndrome. Neurobiology of Aging, 33(9), 1988–1994.CrossRef
Zurück zum Zitat Dekker, A. D., Coppus, A. M., Vermeiren, Y., Aerts, T., van Duijn, C. M., Kremer, B. P., Naude, P. J., Van Dam, D., & De Deyn, P. P. (2014). Serum MHPG strongly predicts conversion to Alzheimer’s Disease in behaviorally characterized subjects with Down syndrome. Journal of Alzheimer’s Disease, 43, 871–891. Dekker, A. D., Coppus, A. M., Vermeiren, Y., Aerts, T., van Duijn, C. M., Kremer, B. P., Naude, P. J., Van Dam, D., & De Deyn, P. P. (2014). Serum MHPG strongly predicts conversion to Alzheimer’s Disease in behaviorally characterized subjects with Down syndrome. Journal of Alzheimer’s Disease, 43, 871–891.
Zurück zum Zitat Evenhuis, H. M. (1992). Evaluation of a screening instrument for dementia in ageing mentally retarded persons. Journal of Intellectual Disability Research, 36(4), 337–347.CrossRef Evenhuis, H. M. (1992). Evaluation of a screening instrument for dementia in ageing mentally retarded persons. Journal of Intellectual Disability Research, 36(4), 337–347.CrossRef
Zurück zum Zitat Evenhuis, H. M. (1996). Further evaluation of the dementia questionnaire for persons with mental retardation (DMR). Journal of Intellectual Disability Research, 40(4), 369–373.CrossRef Evenhuis, H. M. (1996). Further evaluation of the dementia questionnaire for persons with mental retardation (DMR). Journal of Intellectual Disability Research, 40(4), 369–373.CrossRef
Zurück zum Zitat Evenhuis, H. M., Theunissen, M., Denkers, I., Verschuure, H., & Kemme, H. (2001). Prevalence of visual and hearing impairment in a Dutch institutionalized population with intellectual disability. Journal of Intellectual Disability Research, 45(5), 457–464.CrossRef Evenhuis, H. M., Theunissen, M., Denkers, I., Verschuure, H., & Kemme, H. (2001). Prevalence of visual and hearing impairment in a Dutch institutionalized population with intellectual disability. Journal of Intellectual Disability Research, 45(5), 457–464.CrossRef
Zurück zum Zitat Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189–198.CrossRef Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189–198.CrossRef
Zurück zum Zitat Glasson, E. J., Sullivan, S. G., Hussain, R., Petterson, B. A., Montgomery, P. D., & Bittles, A. H. (2002). The changing survival profile of people with Down’s syndrome: Implications for genetic counselling. Clinical Genetics, 62(5), 390–393.CrossRef Glasson, E. J., Sullivan, S. G., Hussain, R., Petterson, B. A., Montgomery, P. D., & Bittles, A. H. (2002). The changing survival profile of people with Down’s syndrome: Implications for genetic counselling. Clinical Genetics, 62(5), 390–393.CrossRef
Zurück zum Zitat Hanney, M., Prasher, V., Williams, N., Jones, E. L., Aarsland, D., Corbett, A., Lawrence, D., Yu, L. M., Tyrer, S., Francis, P. T., Johnson, T., Bullock, R., Ballard, C., & researchers, M. t. (2012). Memantine for dementia in adults older than 40 years with Down’s syndrome (MEADOWS): A randomised, double-blind, placebo-controlled trial. Lancet, 379(9815), 528–536.CrossRef Hanney, M., Prasher, V., Williams, N., Jones, E. L., Aarsland, D., Corbett, A., Lawrence, D., Yu, L. M., Tyrer, S., Francis, P. T., Johnson, T., Bullock, R., Ballard, C., & researchers, M. t. (2012). Memantine for dementia in adults older than 40 years with Down’s syndrome (MEADOWS): A randomised, double-blind, placebo-controlled trial. Lancet, 379(9815), 528–536.CrossRef
Zurück zum Zitat Hardy, J., & Selkoe, D. J. (2002). The amyloid hypothesis of Alzheimer’s disease: Progress and problems on the road to therapeutics. Science, 297(5580), 353–356.CrossRef Hardy, J., & Selkoe, D. J. (2002). The amyloid hypothesis of Alzheimer’s disease: Progress and problems on the road to therapeutics. Science, 297(5580), 353–356.CrossRef
Zurück zum Zitat Hartley, S. L., Handen, B. L., Devenny, D. A., Hardison, R., Mihaila, I., Price, J. C., Cohen, A. D., Klunk, W. E., Mailick, M. R., Johnson, S. C., & Christian, B. T. (2014). Cognitive functioning in relation to brain amyloid-beta in healthy adults with Down syndrome. Brain, 137(9), 2556–2563.CrossRef Hartley, S. L., Handen, B. L., Devenny, D. A., Hardison, R., Mihaila, I., Price, J. C., Cohen, A. D., Klunk, W. E., Mailick, M. R., Johnson, S. C., & Christian, B. T. (2014). Cognitive functioning in relation to brain amyloid-beta in healthy adults with Down syndrome. Brain, 137(9), 2556–2563.CrossRef
Zurück zum Zitat Holland, A. J., Hon, J., Huppert, F. A., Stevens, F., & Watson, P. (1998). Population-based study of the prevalence and presentation of dementia in adults with Down’s syndrome. British Journal of Psychiatry, 172, 493–498.CrossRef Holland, A. J., Hon, J., Huppert, F. A., Stevens, F., & Watson, P. (1998). Population-based study of the prevalence and presentation of dementia in adults with Down’s syndrome. British Journal of Psychiatry, 172, 493–498.CrossRef
Zurück zum Zitat Holland, A. J., Hon, J., Huppert, F. A., & Stevens, F. (2000). Incidence and course of dementia in people with Down’s syndrome: Findings from a population-based study. Journal of Intellectual Disability Research, 44(2), 138–146.CrossRef Holland, A. J., Hon, J., Huppert, F. A., & Stevens, F. (2000). Incidence and course of dementia in people with Down’s syndrome: Findings from a population-based study. Journal of Intellectual Disability Research, 44(2), 138–146.CrossRef
Zurück zum Zitat Hon, J., Huppert, F. A., Holland, A. J., & Watson, P. (1999). Neuropsychological assessment of older adults with Down’s syndrome: An epidemiological study using the Cambridge Cognitive Examination (CAMCOG). British Journal of Clinical Psychology, 38(2), 155–165.CrossRef Hon, J., Huppert, F. A., Holland, A. J., & Watson, P. (1999). Neuropsychological assessment of older adults with Down’s syndrome: An epidemiological study using the Cambridge Cognitive Examination (CAMCOG). British Journal of Clinical Psychology, 38(2), 155–165.CrossRef
Zurück zum Zitat Lott, I. T., Doran, E., Nguyen, V. Q., Tournay, A., Head, E., & Gillen, D. L. (2011). Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation. American Journal of Medical Genetics A, 155A(8), 1939–1948.CrossRef Lott, I. T., Doran, E., Nguyen, V. Q., Tournay, A., Head, E., & Gillen, D. L. (2011). Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation. American Journal of Medical Genetics A, 155A(8), 1939–1948.CrossRef
Zurück zum Zitat Mann, D. M. A. (2006). Neuropathology of Alzheimer’s disease in Down syndrome. Abingdon: Radcliffe Publishing Ltd. Mann, D. M. A. (2006). Neuropathology of Alzheimer’s disease in Down syndrome. Abingdon: Radcliffe Publishing Ltd.
Zurück zum Zitat Margallo-Lana, M. L., Moore, P. B., Kay, D. W., Perry, R. H., Reid, B. E., Berney, T. P., & Tyrer, S. P. (2007). Fifteen-year follow-up of 92 hospitalized adults with Down’s syndrome: Incidence of cognitive decline, its relationship to age and neuropathology. Journal of Intellectual Disability Research, 51(6), 463–477.CrossRef Margallo-Lana, M. L., Moore, P. B., Kay, D. W., Perry, R. H., Reid, B. E., Berney, T. P., & Tyrer, S. P. (2007). Fifteen-year follow-up of 92 hospitalized adults with Down’s syndrome: Incidence of cognitive decline, its relationship to age and neuropathology. Journal of Intellectual Disability Research, 51(6), 463–477.CrossRef
Zurück zum Zitat McCarron, M., Gill, M., McCallion, P., & Begley, C. (2005). Health co-morbidities in ageing persons with Down syndrome and Alzheimer’s dementia. Journal of Intellectual Disability Research, 49(7), 560–566.CrossRef McCarron, M., Gill, M., McCallion, P., & Begley, C. (2005). Health co-morbidities in ageing persons with Down syndrome and Alzheimer’s dementia. Journal of Intellectual Disability Research, 49(7), 560–566.CrossRef
Zurück zum Zitat Mohan, M., Bennett, C., & Carpenter, P. K. (2009a). Galantamine for dementia in people with Down syndrome. Cochrane Database Syst Rev, (1), CD007656. Mohan, M., Bennett, C., & Carpenter, P. K. (2009a). Galantamine for dementia in people with Down syndrome. Cochrane Database Syst Rev, (1), CD007656.
Zurück zum Zitat Mohan, M., Bennett, C., & Carpenter, P. K. (2009b). Rivastigmine for dementia in people with Down syndrome. Cochrane Database Syst Rev, (1), CD007658. Mohan, M., Bennett, C., & Carpenter, P. K. (2009b). Rivastigmine for dementia in people with Down syndrome. Cochrane Database Syst Rev, (1), CD007658.
Zurück zum Zitat Mohan, M., Carpenter, P. K., & Bennett, C. (2009c). Donepezil for dementia in people with Down syndrome. Cochrane Database Syst Rev, (1), CD007178. Mohan, M., Carpenter, P. K., & Bennett, C. (2009c). Donepezil for dementia in people with Down syndrome. Cochrane Database Syst Rev, (1), CD007178.
Zurück zum Zitat Mullins, D., Daly, E., Simmons, A., Beacher, F., Foy, C. M., Lovestone, S., Hallahan, B., Murphy, K. C., & Murphy, D. G. (2013). Dementia in Down’s syndrome: An MRI comparison with Alzheimer’s disease in the general population. Journal of Neurodevelopmental Disorders, 5(1), 19.CrossRef Mullins, D., Daly, E., Simmons, A., Beacher, F., Foy, C. M., Lovestone, S., Hallahan, B., Murphy, K. C., & Murphy, D. G. (2013). Dementia in Down’s syndrome: An MRI comparison with Alzheimer’s disease in the general population. Journal of Neurodevelopmental Disorders, 5(1), 19.CrossRef
Zurück zum Zitat Oliver, C., Crayton, L., Holland, A., Hall, S., & Bradbury, J. (1998). A four year prospective study of age-related cognitive change in adults with Down’s syndrome. Psychological Medicine, 28(6), 1365–1377.CrossRef Oliver, C., Crayton, L., Holland, A., Hall, S., & Bradbury, J. (1998). A four year prospective study of age-related cognitive change in adults with Down’s syndrome. Psychological Medicine, 28(6), 1365–1377.CrossRef
Zurück zum Zitat Prasher, V. P. (1999). Down syndrome and thyroid disorders: A review. Down Syndrome Research and Practice, 6(1), 25–42.CrossRef Prasher, V. P. (1999). Down syndrome and thyroid disorders: A review. Down Syndrome Research and Practice, 6(1), 25–42.CrossRef
Zurück zum Zitat Prasher, V., & Haque, M. S. (2005). Misdiagnosis of thyroid disorders in down syndrome: Time to re-examine the myth? American Journal of Mental Retardation, 110(1), 23–27.CrossRef Prasher, V., & Haque, M. S. (2005). Misdiagnosis of thyroid disorders in down syndrome: Time to re-examine the myth? American Journal of Mental Retardation, 110(1), 23–27.CrossRef
Zurück zum Zitat Prasher, V. P., Farrer, M. J., Kessling, A. M., Fisher, E. M., West, R. J., Barber, P. C., & Butler, A. C. (1998). Molecular mapping of Alzheimer-type dementia in Down’s syndrome. Annals of Neurology, 43(3), 380–383.CrossRef Prasher, V. P., Farrer, M. J., Kessling, A. M., Fisher, E. M., West, R. J., Barber, P. C., & Butler, A. C. (1998). Molecular mapping of Alzheimer-type dementia in Down’s syndrome. Annals of Neurology, 43(3), 380–383.CrossRef
Zurück zum Zitat Prasher, V., Cumella, S., Natarajan, K., Rolfe, E., Shah, S., & Haque, M. S. (2003). Magnetic resonance imaging, Down’s syndrome and Alzheimer’s disease: Research and clinical implications. Journal of Intellectual Disability Research, 47(2), 90–100.CrossRef Prasher, V., Cumella, S., Natarajan, K., Rolfe, E., Shah, S., & Haque, M. S. (2003). Magnetic resonance imaging, Down’s syndrome and Alzheimer’s disease: Research and clinical implications. Journal of Intellectual Disability Research, 47(2), 90–100.CrossRef
Zurück zum Zitat Prasher, V. P., Sajith, S. G., Mehta, P., Zigman, W. B., & Schupf, N. (2010). Plasma beta-amyloid and duration of Alzheimer’s disease in adults with Down syndrome. International Journal of Geriatric Psychiatry, 25(2), 202–207.CrossRef Prasher, V. P., Sajith, S. G., Mehta, P., Zigman, W. B., & Schupf, N. (2010). Plasma beta-amyloid and duration of Alzheimer’s disease in adults with Down syndrome. International Journal of Geriatric Psychiatry, 25(2), 202–207.CrossRef
Zurück zum Zitat Roizen, N. J., & Patterson, D. (2003). Down’s syndrome. Lancet, 361(9365), 1281–1289.CrossRef Roizen, N. J., & Patterson, D. (2003). Down’s syndrome. Lancet, 361(9365), 1281–1289.CrossRef
Zurück zum Zitat Schupf, N., & Sergievsky, G. H. (2002). Genetic and host factors for dementia in Down’s syndrome. British Journal of Psychiatry, 180, 405–410.CrossRef Schupf, N., & Sergievsky, G. H. (2002). Genetic and host factors for dementia in Down’s syndrome. British Journal of Psychiatry, 180, 405–410.CrossRef
Zurück zum Zitat Schupf, N., Kapell, D., Lee, J. H., Zigman, W., Canto, B., Tycko, B., & Mayeux, R. (1996). Onset of dementia is associated with apolipoprotein E epsilon4 in Down’s syndrome. Annals of Neurology, 40(5), 799–801.CrossRef Schupf, N., Kapell, D., Lee, J. H., Zigman, W., Canto, B., Tycko, B., & Mayeux, R. (1996). Onset of dementia is associated with apolipoprotein E epsilon4 in Down’s syndrome. Annals of Neurology, 40(5), 799–801.CrossRef
Zurück zum Zitat Schupf, N., Patel, B., Pang, D., Zigman, W. B., Silverman, W., Mehta, P. D., & Mayeux, R. (2007). Elevated plasma beta-amyloid peptide Abeta (42) levels, incident dementia, and mortality in Down syndrome. Archives of Neurology, 64(7), 1007–1013.CrossRef Schupf, N., Patel, B., Pang, D., Zigman, W. B., Silverman, W., Mehta, P. D., & Mayeux, R. (2007). Elevated plasma beta-amyloid peptide Abeta (42) levels, incident dementia, and mortality in Down syndrome. Archives of Neurology, 64(7), 1007–1013.CrossRef
Zurück zum Zitat Sekijima, Y., Ikeda, S., Tokuda, T., Satoh, S., Hidaka, H., Hidaka, E., Ishikawa, M., & Yanagisawa, N. (1998). Prevalence of dementia of Alzheimer type and apolipoprotein E phenotypes in aged patients with Down’s syndrome. European Neurology, 39(4), 234–237.CrossRef Sekijima, Y., Ikeda, S., Tokuda, T., Satoh, S., Hidaka, H., Hidaka, E., Ishikawa, M., & Yanagisawa, N. (1998). Prevalence of dementia of Alzheimer type and apolipoprotein E phenotypes in aged patients with Down’s syndrome. European Neurology, 39(4), 234–237.CrossRef
Zurück zum Zitat Simard, M., & van Reekum, R. (2001). Dementia with Lewy bodies in Down’s syndrome. International Journal of Geriatric Psychiatry, 16(3), 311–320.CrossRef Simard, M., & van Reekum, R. (2001). Dementia with Lewy bodies in Down’s syndrome. International Journal of Geriatric Psychiatry, 16(3), 311–320.CrossRef
Zurück zum Zitat Smiley, E., Cooper, S. A., Finlayson, J., Jackson, A., Allan, L., Mantry, D., McGrother, C., McConnachie, A., & Morrison, J. (2007). Incidence and predictors of mental ill-health in adults with intellectual disabilities: Prospective study. British Journal of Psychiatry, 191, 313–319.CrossRef Smiley, E., Cooper, S. A., Finlayson, J., Jackson, A., Allan, L., Mantry, D., McGrother, C., McConnachie, A., & Morrison, J. (2007). Incidence and predictors of mental ill-health in adults with intellectual disabilities: Prospective study. British Journal of Psychiatry, 191, 313–319.CrossRef
Zurück zum Zitat Sparrow, SS, Balla, D., & Cicchetti, D. V. (1984). Vineland adaptive behaviour scales, interview edition, expanded form manual. American Guidance Service. Minnesota: Circle Pines. Sparrow, SS, Balla, D., & Cicchetti, D. V. (1984). Vineland adaptive behaviour scales, interview edition, expanded form manual. American Guidance Service. Minnesota: Circle Pines.
Zurück zum Zitat Strydom, A., & Hassiotis, A. (2003). Diagnostic instruments for dementia in older people with intellectual disability in clinical practice. Aging & Mental Health, 7(6), 431–437.CrossRef Strydom, A., & Hassiotis, A. (2003). Diagnostic instruments for dementia in older people with intellectual disability in clinical practice. Aging & Mental Health, 7(6), 431–437.CrossRef
Zurück zum Zitat Strydom, A., Livingston, G., King, M., & Hassiotis, A. (2007). Prevalence of dementia in intellectual disability using different diagnostic criteria. British Journal of Psychiatry, 191, 150–157.CrossRef Strydom, A., Livingston, G., King, M., & Hassiotis, A. (2007). Prevalence of dementia in intellectual disability using different diagnostic criteria. British Journal of Psychiatry, 191, 150–157.CrossRef
Zurück zum Zitat Thune-Boyle, I. C., Iliffe, S., Cerga-Pashoja, A., Lowery, D., & Warner, J. (2012). The effect of exercise on behavioral and psychological symptoms of dementia: Towards a research agenda. International Psychogeriatrics, 24(7), 1046–1057.CrossRef Thune-Boyle, I. C., Iliffe, S., Cerga-Pashoja, A., Lowery, D., & Warner, J. (2012). The effect of exercise on behavioral and psychological symptoms of dementia: Towards a research agenda. International Psychogeriatrics, 24(7), 1046–1057.CrossRef
Zurück zum Zitat Tyrrell, J., Cosgrave, M., McCarron, M., McPherson, J., Calvert, J., Kelly, A., McLaughlin, M., Gill, M., & Lawlor, B. A. (2001). Dementia in people with Down’s syndrome. International Journal of Geriatric Psychiatry, 16(12), 1168–1174.CrossRef Tyrrell, J., Cosgrave, M., McCarron, M., McPherson, J., Calvert, J., Kelly, A., McLaughlin, M., Gill, M., & Lawlor, B. A. (2001). Dementia in people with Down’s syndrome. International Journal of Geriatric Psychiatry, 16(12), 1168–1174.CrossRef
Zurück zum Zitat Van Buggenhout, G. J., Trommelen, J. C., Schoenmaker, A., De Bal, C., Verbeek, J. J., Smeets, D. F., Ropers, H. H., Devriendt, K., Hamel, B. C., & Fryns, J. P. (1999). Down syndrome in a population of elderly mentally retarded patients: Genetic-diagnostic survey and implications for medical care. American Journal of Medical Genetics, 85(4), 376–384.CrossRef Van Buggenhout, G. J., Trommelen, J. C., Schoenmaker, A., De Bal, C., Verbeek, J. J., Smeets, D. F., Ropers, H. H., Devriendt, K., Hamel, B. C., & Fryns, J. P. (1999). Down syndrome in a population of elderly mentally retarded patients: Genetic-diagnostic survey and implications for medical care. American Journal of Medical Genetics, 85(4), 376–384.CrossRef
Zurück zum Zitat van Splunder, J., Stilma, J. S., Bernsen, R. M., Arentz, T. G., & Evenhuis, H. M. (2003). Refractive errors and visual impairment in 900 adults with intellectual disabilities in the Netherlands. Acta Ophthalmologica Scandinavica, 81(2), 123–129.CrossRef van Splunder, J., Stilma, J. S., Bernsen, R. M., Arentz, T. G., & Evenhuis, H. M. (2003). Refractive errors and visual impairment in 900 adults with intellectual disabilities in the Netherlands. Acta Ophthalmologica Scandinavica, 81(2), 123–129.CrossRef
Zurück zum Zitat Visser, F. E., Aldenkamp, A. P., van Huffelen, A. C., Kuilman, M., Overweg, J., & van Wijk, J. (1997). Prospective study of the prevalence of Alzheimer-type dementia in institutionalized individuals with Down syndrome. American Journal of Mental Retardation, 101(4), 400–412. Visser, F. E., Aldenkamp, A. P., van Huffelen, A. C., Kuilman, M., Overweg, J., & van Wijk, J. (1997). Prospective study of the prevalence of Alzheimer-type dementia in institutionalized individuals with Down syndrome. American Journal of Mental Retardation, 101(4), 400–412.
Zurück zum Zitat Weijerman, M. E., van Furth, A. M., Vonk Noordegraaf, A., van Wouwe, J. P., Broers, C. J., & Gemke, R. J. (2008). Prevalence, neonatal characteristics, and first-year mortality of Down syndrome: A national study. Journal of Pediatrics, 152(1), 15–19.CrossRef Weijerman, M. E., van Furth, A. M., Vonk Noordegraaf, A., van Wouwe, J. P., Broers, C. J., & Gemke, R. J. (2008). Prevalence, neonatal characteristics, and first-year mortality of Down syndrome: A national study. Journal of Pediatrics, 152(1), 15–19.CrossRef
Zurück zum Zitat WHO. (1993). World Health Organization, ICD-10: International Statistical Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. WHO. WHO. (1993). World Health Organization, ICD-10: International Statistical Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. WHO.
Zurück zum Zitat Wisniewski, K. E., Dalton, A. J., McLachlan, C., Wen, G. Y., & Wisniewski, H. M. (1985). Alzheimer’s disease in Down’s syndrome: Clinicopathologic studies. Neurology, 35(7), 957–961.CrossRef Wisniewski, K. E., Dalton, A. J., McLachlan, C., Wen, G. Y., & Wisniewski, H. M. (1985). Alzheimer’s disease in Down’s syndrome: Clinicopathologic studies. Neurology, 35(7), 957–961.CrossRef
Zurück zum Zitat Yang, Q., Rasmussen, S. A., & Friedman, J. M. (2002). Mortality associated with Down’s syndrome in the USA from 1983 to 1997: A population-based study. Lancet, 359(9311), 1019–1025.CrossRef Yang, Q., Rasmussen, S. A., & Friedman, J. M. (2002). Mortality associated with Down’s syndrome in the USA from 1983 to 1997: A population-based study. Lancet, 359(9311), 1019–1025.CrossRef
Metadaten
Titel
Demenzielle Erkrankungen bei Menschen mit Down-Syndrom
verfasst von
Dr. Antonia Coppus
Hildegard Telbis-Kankainen
Copyright-Jahr
2016
DOI
https://doi.org/10.1007/978-3-658-09976-3_11