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Polymer Bulletin
Erschienen in: Polymer Bulletin 5/2019

30.08.2018 | Original Paper

Design, characterization and evaluation of oral fast dissolving polymeric films of isradipine inclusion complex

verfasst von: Sayed H. Auda, Abdullah H. Al-Omrani, Fars K. Alanazi, Mohamed M. Badran, Faiyaz Shakeel

Erschienen in: Polymer Bulletin | Ausgabe 5/2019

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Abstract

This study aimed to enhance the dissolution rate of isradipine and to avoid the problem of first-pass metabolism using oral fast dissolving films (OFDFs). Isradipine was complexed with hydroxypropyl-beta-cyclodextrin (HP-β-CD) using the solvent co-evaporation technique to produce an isradipine inclusion complex with increased solubility. This complex was evaluated for its solubility and dissolution behavior compared with the free drug. Then, the inclusion complex was formulated in OFDFs. The fabricated films were evaluated for their drug content uniformity, surface pH, thickness, tensile strength, percent elongation, disintegration time and in vitro drug release profile. Additionally, Fourier transform infrared spectroscopy and differential scanning calorimetry were utilized to characterize the medicated films and the corresponding physical mixture as well as the individual components. The results indicated that the inclusion complexation of isradipine enhances its solubility and dissolution rate. Films were found to be faint yellow, elastic, compatible and palatable and to have acceptable tensile strength. The complexed drug with HP-β-CD in the presence of a high level of disintegrants enhanced the drug dissolution compared to the plain film.
Vorheriger Artikel Synthesis of ascorbic acid-doped oligoaniline, its drug composites and study of their antibacterial behavior
Nächster Artikel Amphiphilic polymer to improve polyplex stability for enhanced transfection efficiency

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Literatur
1.
Zhang H, Zhang J, Streisand JB (2002) Oral mucosal drug delivery: clinical pharmacokinetics and therapeutic applications. Clin Pharmacokinet 41:661–680CrossRefPubMed
2.
Gavaskar B, Kumar SV, Sharan G, Rao YM (2010) Overview of fast dissolving films. Int J Pharm Pharm Sci 2:29–33
3.
Irfan M, Rabel S, Bukhtar Q, Qadir MR, Jabeen F, Khan A (2016) Orally disintegrating films: a modern expansion in drug delivery system. Saudi Pharm J 24:537–546CrossRefPubMed
4.
Papamichael K, Karatzas P, Theodoropoulos I, Kyriakos N, Archavlis E, Mantzaris GJ (2015) Simethicone adjunct to polyethylene glycol improves small bowel capsule endoscopy imaging in non-Crohn’s disease patients. Ann Gastroenterol 28:464–468PubMedPubMedCentral
5.
Otero-Espinar FJ, Torres-Labandeira JJ, Alvarez-Lorenzo C, Blanco-Mendez J (2010) Cyclodextrins in drug delivery systems. J Drug Deliv Sci Technol 20:289–301CrossRef
6.
Mura P, Faucci MT, Parrini PL (2001) Effects of grinding with microcrystalline cellulose and cyclodextrins on the ketoprofen physicochemical properties. Drug Dev Ind Pharm 27:119–128CrossRefPubMed
7.
Moyano JR, Arias-Blanco MJ, Gines JM, Giordano F (1997) Solid-state characterization and dissolution characteristics of gliclazide-b-cyclodextrin inclusion complexes. Int J Pharm 157:239–243CrossRefPubMed
8.
Pandit V, Gorantla R, Devi K, Pai RS, Sarasija S (2011) Preparation and characterization of pioglitazone cyclodextrin inclusion complexes. J Young Pharm 3:267–274CrossRefPubMedPubMedCentral
9.
Pose-Vilarnovo B, Perdomo-Lopez L, Echezarreta-Lopez M, Schroth-Pardo P, Torres-Labandeira JJ (2001) Improvement of water solubility of sulfamethizole through its complexation with beta- and hydroxypropyl-beta-cyclodextrin. characterization of the interaction in solution and solid state. Eur J Pharm Sci 13:325–331CrossRefPubMed
10.
Saito M, Ugajin T, Nozawa Y, Sadzuka Y, Miagishima A, Sonobe T (2002) Preparation and dissolution characteristics of griseofulvin solid dispersions with saccharides. Int J Pharm 249:71–79CrossRefPubMed
11.
Yang P, Li Y, Li W, Zhang H, Gao J, Sun J, Yin X, Zheng A (2018) Preparation and evaluation of carfentanil nasal spray employing cyclodextrin inclusion technology. Drug Dev Ind Pharm 44:953–960CrossRefPubMed
12.
Mangolim CM, Moriwaki C, Nogueira AC, Sato F, Baesso ML, Neto AM, Matioli G (2014) Curcumin-β-cyclodextrin inclusion complex: stability, solubility, characterisation by FT-IR, FT-Raman, X-ray diffraction and photoacoustic spectroscopy, and food application. Food Chem 153:361–370CrossRefPubMed
13.
14.
Miyashita Y, Peterson D, Rees JM, Flynn JT (2010) Isradipine for the treatment of acute hypertension in hospitalized children and adolescents. J Clin Hypertens 12:850–855CrossRef
15.
Cipriani A, Saunders K, Attenburrow MJ, Stefaniak J, Panchal P, Stockton S, Lane TA, Tunbridge EM, Geddes JR, Harrison PJ (2016) A systematic review of calcium channel antagonists in bipolar disorder and some considerations for their future developments. Mol Psychiatry 21:1324–1332CrossRefPubMedPubMedCentral
16.
Peter EP, Shirley CS, Antone FS (1988) Isradipine in the treatment of angina pectoris. Am J Med 84:62–66CrossRef
17.
Christensen HR, Antonsen K, Simonsen K, Lindekaer A, Bonde J, Angelo HR, Kampmann JP (2000) Bioavailability and pharmacokinetics of isradipine after oral and intravenous administration: half-life shorter than expected. Pharmacol Toxicol 86:178–182CrossRefPubMed
18.
Rekha MS, Sultana SKS, Mahathi K, Parveen P, Prathima B, Devi AS (2015) Formulation and evaluation of fast dissolving buccal film containing isradipine solid dispersion. Am J PharmTech Res 5:222–247
19.
Kaewnopparat N, Chuchom T, Sunthornpit A, Jangwang A, Kaewnopparat S (2009) Enhanced bromhexine hydrochloride solubility and dissolution by inclusion complexation with methylated β-cyclodextrin. Asian J Pharm Sci 5:114–122
20.
Bergstrom CAS, Larsson P (2018) Computational prediction of drug solubility in water-based systems: qualitative and quantitative approaches used in the current discovery and development setting. Int J Pharm 540:185–193CrossRefPubMedPubMedCentral
21.
Katariya H, Prajapati J (2013) Development and validation of UV spectrophotometric method for determination of isradipine loaded into solid lipid nanoparticles. Int J Pharm Sci Rev Res 20:162–166
22.
Barbic U, Verdenik I, Marolt M, Hren NI (2016) Three-dimensional ultrasound evaluation of tongue volume. Zdrav Vestn 85:228–236
23.
Tomar A, Sharma K, Chauhan NS, Mittal A, Bajaj U (2012) Formulation and evaluation of fast dissolving oral film of dicyclomine as potential route of buccal delivery. Int J Drug Dev Res 4:408–417
24.
Maheswari KM, Devineni PK, Deekonda S, Shaik S, Uppala NP, Nalluri BN (2014) Development and evaluation of mouth dissolving films of amlodipine besylate for enhanced therapeutic efficacy. J Pharm 2014:E520949
25.
Upreti K, Kumar L, Anand SP, Chawla V (2014) Formulation and evaluation of mouth dissolving films of paracetamol. Int J Pharm Pharm Sci 6:200–202
26.
Kumria R, Nair AB, Al-Dhubiab BE (2014) Loratidine buccal films for allergic rhinitis: development and evaluation. Drug Dev Ind Pharm 40:625–631CrossRefPubMed
27.
Auda SH, Salem-Bekhit MM, Alanazi FK, Alsarra IA, Shakeel F (2017) Antimicrobial evaluation of novel buccoadhesive films containing Myrrh extract. Polym Bull 74:4041–4054CrossRef
28.
Tran PH, Tran TT, Piao ZZ, Lim JT, Oh YS, Rhee BJ (2013) Physical properties and in vivo bioavailability in human volunteers of isradipine using controlled release matrix tablet containing self-emulsifying solid dispersion. Int J Pharm 450:79–86CrossRefPubMed
29.
Anwer MK, Jamil S, Ansari MJ, Al-Shdefat R, Ali BE, Ganaie MA, Abdel-Kader MS, Shakeel F (2014) Water soluble binary and ternary complexes of diosmin with β-cyclodextrin: spectroscopic characterization, release studies and anti-oxidant activity. J Mol Liq 199:35–41CrossRef
30.
Aloisio C, Antimisiaris SG, Longhi MR (2017) Liposomes containing cyclodextrins or meglumine to solubilize and improve the bioavailability of poorly soluble drugs. J Mol Liq 229:106–113CrossRef
31.
Altamimi MA, Elzayat EM, Alhowyan AA, Alshehri S, Shakeel F (2018) Effect of β-cyclodextrin and different surfactants on solubility, stability, and permeability of hydrochlorothiazide. J Mol Liq 250:323–328CrossRef
32.
Loftsson T, Magnúsdóttir A, Másson M, Sigurjónsdóttir JF (2002) Self-association and cyclodextrin solubilization of drugs. J Pharm Sci 91:2307–2316CrossRefPubMed
33.
Conceicao J, Adeoye O, Cabral-Marques HM, Lobo JMS (2018) Cyclodextrins as excipients in tablet formulations. Drug Discov Today 23:1274–1284CrossRefPubMed
34.
Soltani N, Shaynafar A, Djozan D, Jouyban A (2013) Solubility of three basic drugs in propylene glycol + water mixtures in the presence of β-cyclodextrin. J Drug Deliv Sci Technol 23:187–190CrossRef
35.
Ramasahayam B, Eedara BB, Kandadi P, Jukanti R, Bandari S (2015) Development of isradipine loaded self-nano emulsifying powders for improved oral delivery: in vitro and in vivo evaluation. Drug Dev Ind Pharm 41:753–763CrossRefPubMed
36.
37.
Shazly GA, Ibrahim MA, Badran MM, Zoheir KA (2012) Utilizing Pluronic F-127 and G elucire 50/13 solid dispersions for enhanced skin delivery of flufenamic acid. Drug Dev Res 73:299–307CrossRef
38.
Teotia A, Ikram S, Gupta B (2012) Structural characterization of chitosan and oxidized carboxymethyl cellulose based freeze-dried films. Polym Bull 69:175–188CrossRef
39.
Sahiner M, Alpaslan D, Bitlisli BO (2014) Collagen-based hydrogel films as drug-delivery devices with antimicrobial properties. Polym Bull 71:3017–3033CrossRef
40.
Maslakci NN, Ulusoy S, Uygun E, Cevikbas H, Oksuz L, Can HK, Oksuz AU (2017) Ibuprofen and acetylsalicylic acid loaded electrospun PVP-dextran nanofiber mats for biomedical applications. Polym Bull 74:3283–3299CrossRef
Metadaten
Titel
Design, characterization and evaluation of oral fast dissolving polymeric films of isradipine inclusion complex
verfasst von
Sayed H. Auda
Abdullah H. Al-Omrani
Fars K. Alanazi
Mohamed M. Badran
Faiyaz Shakeel
Publikationsdatum
30.08.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Polymer Bulletin / Ausgabe 5/2019
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-018-2503-y

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