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Polymer Bulletin
Erschienen in: Polymer Bulletin 7/2024

14.09.2023 | ORIGINAL PAPER

Development of tamarind gum/β-CD-co-poly (MAA) hydrogels for pH-driven controlled delivery of capecitabine

verfasst von: Iqra Ahmed, Asif Mahmood, Omer Salman Qureshi, Rai Muhammad Sarfraz, Hira Ijaz, Muhammad Zaman, Muhammad Rouf Akram, Sufyan Usmani, Zulcaif, Maria Malook

Erschienen in: Polymer Bulletin | Ausgabe 7/2024

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Abstract

A novel N,N methylene-bis-acrylamide (MBA) crosslinked tamarind gum and β-cyclodextrin graft-poly(methacrylic acid) (TG/β-CG-g-MAA) hydrogel was formulated for colon targeting. The swelling capability, mechanical strength, sol–gel fraction (%), in vitro release and in vivo toxicological screening were estimated experimentally. The effect of polymers, monomer and crosslinker on percentage drug loading, swelling and drug release was determined. TG/β-CD-g-MAA hydrogel was characterized by FTIR, thermal analysis, X-ray diffraction (XRD) analysis and scanning electron microscopy (SEM). Swelling was significant at pH 7.4 as compared to pH 1.2. Drug release studies showed that release was significant at pH 7.4 as compared to pH 1.2. Developed hydrogels were porous, thermally stable, offered uniform distribution of amorphous drug and pH-dependent capecitabine release in controlled fashion. Kinetic modelling revealed zero-order drug release and Korsmeyer-Peppas model mechanism of release. Lastly, TG/β-CD-g-MAA hydrogel (F11) can act as prospective pH-responsive carrier for colon targeting.

Graphical abstract

Vorheriger Artikel Characterization and drug release kinetics of polyacrylamide/sodium alginate blend hydrogels synthesized by gamma irradiation
Nächster Artikel The effect of hydrophobic coating applied to mica reinforced epoxy matrix composites on the water absorption properties of the composite

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Metadaten
Titel
Development of tamarind gum/β-CD-co-poly (MAA) hydrogels for pH-driven controlled delivery of capecitabine
verfasst von
Iqra Ahmed
Asif Mahmood
Omer Salman Qureshi
Rai Muhammad Sarfraz
Hira Ijaz
Muhammad Zaman
Muhammad Rouf Akram
Sufyan Usmani
Zulcaif
Maria Malook
Publikationsdatum
14.09.2023
Verlag
Springer Berlin Heidelberg
Erschienen in
Polymer Bulletin / Ausgabe 7/2024
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-023-04999-9

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