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Erschienen in: Quality of Life Research 8/2016

24.12.2015

Drug persistence and compliance affect patient-reported outcomes in overactive bladder syndrome

verfasst von: Tae Heon Kim, Myung-Soo Choo, Young-Joo Kim, Hyein Koh, Kyu-Sung Lee

Erschienen in: Quality of Life Research | Ausgabe 8/2016

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Abstract

Purpose

To evaluate persistence and compliance for patients receiving antimuscarinics for overactive bladder (OAB), and to assess patient-reported outcomes (PROs) according to persistence and compliance.

Methods

This was a 24-week, multicenter, prospective, observational study that included 952 OAB patients who had newly started antimuscarinics. Patients aged ≥18 years with a total OAB Symptom Score (OABSS) ≥3 and an urgency score of OABSS ≥2 were eligible for the study. Drug persistence and compliance were evaluated at 4, 12, and 24 weeks. Changes in scores on PROs were compared between groups (persistence vs. non-persistence and compliance vs. non-compliance) after 24 weeks. Factors contributing to persistence were examined using multivariate logistic regression.

Results

After 24 weeks, 56.8 % of patients remained on treatment. The persistence rates were 85.6 and 71.4 % after 4 and 12 weeks, respectively. The compliance rates were 75.6, 53.8, and 34.3 % after 4, 12, and 24 weeks, respectively. Patients who were persistent in taking antimuscarinics resulted in significant improvements in OABSS and OAB questionnaire short form score compared with those who were non-persistent (all p < 0.05). Changes from baseline in OABSS (p = 0.735) and the EuroQoL five-dimensions score (p = 0.384) were not significantly different between compliant and non-compliant groups. Predictors of high persistence included older age (OR 1.017, p = 0.007) and dry OAB (OR 1.422, p = 0.013).

Conclusions

Patients who were persistent with antimuscarinics showed significant improvements in PROs compared to those who were non-persistent.

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Literatur
1.
Zurück zum Zitat Abrams, P., Cardozo, L., Fall, M., Griffiths, D., Rosier, P., Ulmsten, U., et al. (2002). The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Neurourology and Urodynamics, 21(2), 167–178.CrossRefPubMed Abrams, P., Cardozo, L., Fall, M., Griffiths, D., Rosier, P., Ulmsten, U., et al. (2002). The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Neurourology and Urodynamics, 21(2), 167–178.CrossRefPubMed
2.
Zurück zum Zitat Haylen, B. T., de Ridder, D., Freeman, R. M., Swift, S. E., Berghmans, B., Lee, J., et al. (2010). An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. International Urogynecology Journal, 21(1), 5–26.CrossRefPubMed Haylen, B. T., de Ridder, D., Freeman, R. M., Swift, S. E., Berghmans, B., Lee, J., et al. (2010). An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. International Urogynecology Journal, 21(1), 5–26.CrossRefPubMed
3.
Zurück zum Zitat Irwin, D. E., Milsom, I., Hunskaar, S., Reilly, K., Kopp, Z., Herschorn, S., Coyne, K., Kelleher, C., Hampel, C., Artibani, W., & Abrams, P. (2006). Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. European Urology, 50(6), 1306–1314; discussion 1314-1305. Irwin, D. E., Milsom, I., Hunskaar, S., Reilly, K., Kopp, Z., Herschorn, S., Coyne, K., Kelleher, C., Hampel, C., Artibani, W., & Abrams, P. (2006). Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. European Urology, 50(6), 1306–1314; discussion 1314-1305.
4.
Zurück zum Zitat Lee, Y. S., Lee, K. S., Jung, J. H., Han, D. H., Oh, S. J., Seo, J. T., et al. (2011). Prevalence of overactive bladder, urinary incontinence, and lower urinary tract symptoms: results of Korean EPIC study. World Journal of Urology, 29(2), 185–190.CrossRefPubMed Lee, Y. S., Lee, K. S., Jung, J. H., Han, D. H., Oh, S. J., Seo, J. T., et al. (2011). Prevalence of overactive bladder, urinary incontinence, and lower urinary tract symptoms: results of Korean EPIC study. World Journal of Urology, 29(2), 185–190.CrossRefPubMed
5.
Zurück zum Zitat Kim, T. H., Han, D. H., & Lee, K. S. (2014). The prevalence of lower urinary tract symptoms in korean men aged 40 years or older: A population-based survey. International Neurourology Journal, 18(3), 126–132.CrossRefPubMedPubMedCentral Kim, T. H., Han, D. H., & Lee, K. S. (2014). The prevalence of lower urinary tract symptoms in korean men aged 40 years or older: A population-based survey. International Neurourology Journal, 18(3), 126–132.CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Coyne, K. S., Sexton, C. C., Irwin, D. E., Kopp, Z. S., Kelleher, C. J., & Milsom, I. (2008). The impact of overactive bladder, incontinence and other lower urinary tract symptoms on quality of life, work productivity, sexuality and emotional well-being in men and women: results from the EPIC study. BJU International, 101(11), 1388–1395.CrossRefPubMed Coyne, K. S., Sexton, C. C., Irwin, D. E., Kopp, Z. S., Kelleher, C. J., & Milsom, I. (2008). The impact of overactive bladder, incontinence and other lower urinary tract symptoms on quality of life, work productivity, sexuality and emotional well-being in men and women: results from the EPIC study. BJU International, 101(11), 1388–1395.CrossRefPubMed
7.
Zurück zum Zitat Coyne, K. S., Sexton, C. C., Kopp, Z. S., Ebel-Bitoun, C., Milsom, I., & Chapple, C. (2011). The impact of overactive bladder on mental health, work productivity and health-related quality of life in the UK and Sweden: Results from EpiLUTS. BJU International, 108(9), 1459–1471.CrossRefPubMed Coyne, K. S., Sexton, C. C., Kopp, Z. S., Ebel-Bitoun, C., Milsom, I., & Chapple, C. (2011). The impact of overactive bladder on mental health, work productivity and health-related quality of life in the UK and Sweden: Results from EpiLUTS. BJU International, 108(9), 1459–1471.CrossRefPubMed
8.
Zurück zum Zitat Lee, Y. I., Kim, J. W., Bae, S. R., Paick, S. H., Kim, K. W., Kim, H. G., et al. (2013). Effect of urgency symptoms on the risk of depression in community-dwelling elderly men. Korean Journal of Urology, 54(11), 762–766.CrossRefPubMedPubMedCentral Lee, Y. I., Kim, J. W., Bae, S. R., Paick, S. H., Kim, K. W., Kim, H. G., et al. (2013). Effect of urgency symptoms on the risk of depression in community-dwelling elderly men. Korean Journal of Urology, 54(11), 762–766.CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Park, H. K., Chang, S., Palmer, M. H., Kim, I., & Choi, H. (2015). Assessment of the impact of male urinary incontinence on health-related quality of life: A population based study. Luts-Lower Urinary Tract Symptoms, 7(1), 22–26.CrossRef Park, H. K., Chang, S., Palmer, M. H., Kim, I., & Choi, H. (2015). Assessment of the impact of male urinary incontinence on health-related quality of life: A population based study. Luts-Lower Urinary Tract Symptoms, 7(1), 22–26.CrossRef
10.
Zurück zum Zitat Andersson, K. E., Chapple, C. R., Cardozo, L., Cruz, F., Hashim, H., Michel, M. C., et al. (2009). Pharmacological treatment of overactive bladder: Report from the International Consultation on Incontinence. Current Opinion in Urology, 19(4), 380–394.CrossRefPubMed Andersson, K. E., Chapple, C. R., Cardozo, L., Cruz, F., Hashim, H., Michel, M. C., et al. (2009). Pharmacological treatment of overactive bladder: Report from the International Consultation on Incontinence. Current Opinion in Urology, 19(4), 380–394.CrossRefPubMed
11.
Zurück zum Zitat Haab, F., Cardozo, L., Chapple, C., Ridder, A. M., & Solifenacin Study, G. (2005). Long-term open-label solifenacin treatment associated with persistence with therapy in patients with overactive bladder syndrome. European Urology, 47(3), 376–384.CrossRefPubMed Haab, F., Cardozo, L., Chapple, C., Ridder, A. M., & Solifenacin Study, G. (2005). Long-term open-label solifenacin treatment associated with persistence with therapy in patients with overactive bladder syndrome. European Urology, 47(3), 376–384.CrossRefPubMed
12.
Zurück zum Zitat Sexton, C. C., Notte, S. M., Maroulis, C., Dmochowski, R. R., Cardozo, L., Subramanian, D., & Coyne, K. S. (2011). Persistence and adherence in the treatment of overactive bladder syndrome with anticholinergic therapy: A systematic review of the literature. International Journal of Clinical Practice, 65(5), 567–585.CrossRefPubMed Sexton, C. C., Notte, S. M., Maroulis, C., Dmochowski, R. R., Cardozo, L., Subramanian, D., & Coyne, K. S. (2011). Persistence and adherence in the treatment of overactive bladder syndrome with anticholinergic therapy: A systematic review of the literature. International Journal of Clinical Practice, 65(5), 567–585.CrossRefPubMed
13.
Zurück zum Zitat Cramer, J. A., Roy, A., Burrell, A., Fairchild, C. J., Fuldeore, M. J., Ollendorf, D. A., & Wong, P. K. (2008). Medication compliance and persistence: Terminology and definitions. Value Health, 11(1), 44–47.CrossRefPubMed Cramer, J. A., Roy, A., Burrell, A., Fairchild, C. J., Fuldeore, M. J., Ollendorf, D. A., & Wong, P. K. (2008). Medication compliance and persistence: Terminology and definitions. Value Health, 11(1), 44–47.CrossRefPubMed
14.
Zurück zum Zitat Yu, Y. F., Nichol, M. B., Yu, A. P., & Ahn, J. (2005). Persistence and adherence of medications for chronic overactive bladder/urinary incontinence in the california medicaid program. Value Health, 8(4), 495–505.CrossRefPubMed Yu, Y. F., Nichol, M. B., Yu, A. P., & Ahn, J. (2005). Persistence and adherence of medications for chronic overactive bladder/urinary incontinence in the california medicaid program. Value Health, 8(4), 495–505.CrossRefPubMed
15.
Zurück zum Zitat Shaya, F. T., Blume, S., Gu, A., Zyczynski, T., & Jumadilova, Z. (2005). Persistence with overactive bladder pharmacotherapy in a Medicaid population. American Journal of Managed Care, 11(4 Suppl), S121–S129.PubMed Shaya, F. T., Blume, S., Gu, A., Zyczynski, T., & Jumadilova, Z. (2005). Persistence with overactive bladder pharmacotherapy in a Medicaid population. American Journal of Managed Care, 11(4 Suppl), S121–S129.PubMed
16.
Zurück zum Zitat Wagg, A., Compion, G., Fahey, A., & Siddiqui, E. (2012). Persistence with prescribed antimuscarinic therapy for overactive bladder: A UK experience. BJU International, 110(11), 1767–1774.CrossRefPubMed Wagg, A., Compion, G., Fahey, A., & Siddiqui, E. (2012). Persistence with prescribed antimuscarinic therapy for overactive bladder: A UK experience. BJU International, 110(11), 1767–1774.CrossRefPubMed
17.
Zurück zum Zitat Homma, Y., Yoshida, M., Seki, N., Yokoyama, O., Kakizaki, H., Gotoh, M., et al. (2006). Symptom assessment tool for overactive bladder syndrome–overactive bladder symptom score. Urology, 68(2), 318–323.CrossRefPubMed Homma, Y., Yoshida, M., Seki, N., Yokoyama, O., Kakizaki, H., Gotoh, M., et al. (2006). Symptom assessment tool for overactive bladder syndrome–overactive bladder symptom score. Urology, 68(2), 318–323.CrossRefPubMed
18.
Zurück zum Zitat Rammstedt, B., & John, O. (2007). Measuring personality in one minute or less: A 10-item short version of the Big Five Inventory in English and German. Journal of Research in Personality, 41(1), 203–212.CrossRef Rammstedt, B., & John, O. (2007). Measuring personality in one minute or less: A 10-item short version of the Big Five Inventory in English and German. Journal of Research in Personality, 41(1), 203–212.CrossRef
19.
Zurück zum Zitat Ho, P. M., Bryson, C. L., & Rumsfeld, J. S. (2009). Medication adherence: Its importance in cardiovascular outcomes. Circulation, 119(23), 3028–3035.CrossRefPubMed Ho, P. M., Bryson, C. L., & Rumsfeld, J. S. (2009). Medication adherence: Its importance in cardiovascular outcomes. Circulation, 119(23), 3028–3035.CrossRefPubMed
20.
Zurück zum Zitat EuroQol, G. (1990). EuroQol–a new facility for the measurement of health-related quality of life. Health Policy, 16(3), 199–208.CrossRef EuroQol, G. (1990). EuroQol–a new facility for the measurement of health-related quality of life. Health Policy, 16(3), 199–208.CrossRef
21.
Zurück zum Zitat Coyne, K., Revicki, D., Hunt, T., Corey, R., Stewart, W., Bentkover, J., et al. (2002). Psychometric validation of an overactive bladder symptom and health-related quality of life questionnaire: The OAB-q. Quality of Life Research, 11(6), 563–574.CrossRefPubMed Coyne, K., Revicki, D., Hunt, T., Corey, R., Stewart, W., Bentkover, J., et al. (2002). Psychometric validation of an overactive bladder symptom and health-related quality of life questionnaire: The OAB-q. Quality of Life Research, 11(6), 563–574.CrossRefPubMed
22.
Zurück zum Zitat Oh, S. J., Son, H., Kim, S. W., Lee, K. S., Choo, M. S., Kim, S. O., & Lee, M. S. (2012). Psychometric properties of the Korean Version of the Overactive Bladder Questionnaire (OAB-q) in a Korean Population. International Neurourology Journal, 16(2), 77–85.CrossRefPubMedPubMedCentral Oh, S. J., Son, H., Kim, S. W., Lee, K. S., Choo, M. S., Kim, S. O., & Lee, M. S. (2012). Psychometric properties of the Korean Version of the Overactive Bladder Questionnaire (OAB-q) in a Korean Population. International Neurourology Journal, 16(2), 77–85.CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Daniel, W. (1999). Biostatistics: A foundation for analysis in the health sciences. New York: Wiley. Daniel, W. (1999). Biostatistics: A foundation for analysis in the health sciences. New York: Wiley.
24.
Zurück zum Zitat Hosmer, D, Jr, & Lemeshow, S. (1989). Applied logistic regression. New York: Wiley. Hosmer, D, Jr, & Lemeshow, S. (1989). Applied logistic regression. New York: Wiley.
25.
Zurück zum Zitat Krueger, K. P., Berger, B. A., & Felkey, B. (2005). Medication adherence and persistence: a comprehensive review. Advances in Therapy, 22(4), 313–356.CrossRefPubMed Krueger, K. P., Berger, B. A., & Felkey, B. (2005). Medication adherence and persistence: a comprehensive review. Advances in Therapy, 22(4), 313–356.CrossRefPubMed
26.
Zurück zum Zitat Veenboer, P. W., & Bosch, J. L. (2014). Long-term adherence to antimuscarinic therapy in everyday practice: a systematic review. Journal of Urology, 191(4), 1003–1008.CrossRefPubMed Veenboer, P. W., & Bosch, J. L. (2014). Long-term adherence to antimuscarinic therapy in everyday practice: a systematic review. Journal of Urology, 191(4), 1003–1008.CrossRefPubMed
27.
Zurück zum Zitat Sears, C. L., Lewis, C., Noel, K., Albright, T. S., & Fischer, J. R. (2010). Overactive bladder medication adherence when medication is free to patients. Journal of Urology, 183(3), 1077–1081.CrossRefPubMed Sears, C. L., Lewis, C., Noel, K., Albright, T. S., & Fischer, J. R. (2010). Overactive bladder medication adherence when medication is free to patients. Journal of Urology, 183(3), 1077–1081.CrossRefPubMed
28.
Zurück zum Zitat D’Souza, A. O., Smith, M. J., Miller, L. A., Doyle, J., & Ariely, R. (2008). Persistence, adherence, and switch rates among extended-release and immediate-release overactive bladder medications in a regional managed care plan. Journal of Managed Care Pharmacy, 14(3), 291–301.CrossRefPubMed D’Souza, A. O., Smith, M. J., Miller, L. A., Doyle, J., & Ariely, R. (2008). Persistence, adherence, and switch rates among extended-release and immediate-release overactive bladder medications in a regional managed care plan. Journal of Managed Care Pharmacy, 14(3), 291–301.CrossRefPubMed
29.
Zurück zum Zitat Yeaw, J., Benner, J. S., Walt, J. G., Sian, S., & Smith, D. B. (2009). Comparing adherence and persistence across 6 chronic medication classes. Journal of Managed Care Pharmacy, 15(9), 728–740.CrossRefPubMed Yeaw, J., Benner, J. S., Walt, J. G., Sian, S., & Smith, D. B. (2009). Comparing adherence and persistence across 6 chronic medication classes. Journal of Managed Care Pharmacy, 15(9), 728–740.CrossRefPubMed
30.
Zurück zum Zitat Athanasopoulos, A., & Giannitsas, K. (2011). An overview of the clinical use of antimuscarinics in the treatment of overactive bladder. Advances in Therapy, 2011, 820816. Athanasopoulos, A., & Giannitsas, K. (2011). An overview of the clinical use of antimuscarinics in the treatment of overactive bladder. Advances in Therapy, 2011, 820816.
Metadaten
Titel
Drug persistence and compliance affect patient-reported outcomes in overactive bladder syndrome
verfasst von
Tae Heon Kim
Myung-Soo Choo
Young-Joo Kim
Hyein Koh
Kyu-Sung Lee
Publikationsdatum
24.12.2015
Verlag
Springer International Publishing
Erschienen in
Quality of Life Research / Ausgabe 8/2016
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-015-1216-z

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