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Medical & Biological Engineering & Computing

Erschienen in:

01.03.2009 | Original Article

Early afterdepolarisations and ventricular arrhythmias in cardiac tissue: a computational study

verfasst von: Simon Scarle, Richard H. Clayton

Erschienen in: Medical & Biological Engineering & Computing | Ausgabe 3/2009

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Abstract

Afterdepolarisations are associated with arrhythmias in the heart, but are difficult to study experimentally. In this study we used a simplified computational model of 1D and 2D cardiac ventricular tissue, where we could control the size of the region generating afterdepolarisations, as well as the properties of the afterdepolarisation waveform. Provided the size of the afterdepolarisation region was greater than around 1 mm, propagating extrasystoles were produced in both 1D and 2D. The number of extrasystoles produced depended on the amplitude, period, and duration of the oscillatory EAD waveform. In 2D, re-entry was also initiated for specific combinations of EAD amplitude, period, and duration, with the afterdepolarisation region acting as a common pathway. The main finding from this modelling study is therefore that afterdepolarisations can act as potent sources of propagating extrasystoles, as well as a source of re-entrant activation.

Vorheriger Artikel A model for transcutaneous current stimulation: simulations and experiments

Nächster Artikel Modeling the macro-structure of the heart: healthy and diseased

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Titel: Early afterdepolarisations and ventricular arrhythmias in cardiac tissue: a computational study
verfasst von: Simon Scarle
Richard H. Clayton
Publikationsdatum: 01.03.2009
Verlag: Springer-Verlag
Erschienen in: Medical & Biological Engineering & Computing / Ausgabe 3/2009
Print ISSN: 0140-0118
Elektronische ISSN: 1741-0444
DOI: https://doi.org/10.1007/s11517-008-0405-0

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