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Journal of Polymer Research
Erschienen in: Journal of Polymer Research 5/2021

01.05.2021 | ORIGINAL PAPER

Effect of poly(lactic-co-glycolic acid) blend ratios on the hydrolytic degradation of poly(para-dioxanone)

verfasst von: Xiliang Liu, Peijie Hou, Song Liu, Jin Qi, Shaomin Feng, Lifang Zhang, Pan Ma, Wei Bai

Erschienen in: Journal of Polymer Research | Ausgabe 5/2021

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Abstract

The poly(para-dioxanone) (PPDO) was blended with various contents of poly(lactic-co-glycolic acid) (PLGA) (10wt%, 20wt%, 30wt%) by solution co-precipitation in this study. The advantage of PLGA is derived from its safety and low cost. The hydrolytic degradation of PPDO / PLGA blends in vitro was studied by weight loss, water absorption, thermal properties, surface morphology, and mechanical properties in phosphate-buffered saline (pH = 7.44) at 37 ℃ for 8 weeks. After degradation, the weight loss and water absorption of all blends increased significantly. PPDO/PLGA (70/30) showed the largest weight loss during the whole degradation period. With the prolongation of hydrolysis degradation time, higher crystallinity of the PPDO was attributed to the chain breakage of unstable ester bonds. A fenestral structure with defects was formed on the surface of the blend bars with degradation. Besides, the glass transition temperature (Tg), the melting temperature (Tm), tensile strength, and breaking elongation of the blends decreased with the hydrolysis rate varying with the blend composition. Compared with pure PLGA and pure PPDO, the PPDO/PLGA blends exhibited a higher hydrolysis rate because of poor miscibility. Therefore, PPDO/PLGA blends with tailored degradation times have a lot of potential as a biomaterial for biomedical applications, such as high-performance absorbable sutures or a filler for ameliorating facial wrinkles.
Vorheriger Artikel Effect of anion on CO2 capture in PVC–g–P[VBIm][X] ionomers: experimental and density functional theory studies
Nächster Artikel Synthesis and characterization of polyvinyl alcohol/water-hyacinth (Eichhornia crassipes) based hydrogel by applying gamma radiation

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Metadaten
Titel
Effect of poly(lactic-co-glycolic acid) blend ratios on the hydrolytic degradation of poly(para-dioxanone)
verfasst von
Xiliang Liu
Peijie Hou
Song Liu
Jin Qi
Shaomin Feng
Lifang Zhang
Pan Ma
Wei Bai
Publikationsdatum
01.05.2021
Verlag
Springer Netherlands
Erschienen in
Journal of Polymer Research / Ausgabe 5/2021
Print ISSN: 1022-9760
Elektronische ISSN: 1572-8935
DOI
https://doi.org/10.1007/s10965-021-02529-7

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