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Experimental Mechanics
Erschienen in: Experimental Mechanics 1/2021

14.10.2020 | Sp Iss: Experimental Advances in Cardiovascular Biomechanics

Effects of Red Blood Cell Sickling on Right Ventricular Afterload in vivo

verfasst von: D. A. Schreier, T. A. Hacker, D. M. Tabima, M. O. Platt, N. C. Chesler

Erschienen in: Experimental Mechanics | Ausgabe 1/2021

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Abstract

Background

Hemolysis in sickle cell disease (SCD) releases cell free hemoglobin, which scavenges nitric oxide (NO), leading to pulmonary vascular vasoconstriction, increased pulmonary vascular resistance (PVR), and the development of PH. However, PVR is only one component of right ventricular (RV) afterload. Whether sickled red blood cells increase the total RV afterload, including compliance and wave reflections, is unclear.

Objective

Patients with SCD and pulmonary hypertension (PH) have a significantly increased risk of sudden death compared to patients with SCD alone. Sickled red blood cells (RBCs) are fragile and lyse easily. Here, we sought to determine the acute effects of SCD RBCs and increased cell free hemoglobin on RV afterload.

Methods

Main pulmonary artery pressures and flows were measured in C57BL6 mice before and after exchanges of whole blood (~200 uL, Hct = 45%) with an equal volume of SCD RBCs in plasma (Hct = 45%) or cell free hemoglobin (Hb+) in solution. After transfusions, animals were additionally stressed with acute hypoxia (AH; 10% O2).

Results

SCD RBCs increased PVR only compared to control RBCs; cell free hemoglobin increased PVR and wave reflections. These increases in RV afterload increased further with AH.

Conclusions

The release of cell free hemoglobin from fragile SCD RBCs in vivo increases the total RV afterload and may impair RV function more than the SCD RBCs themselves.
Vorheriger Artikel Arterial Wall Stiffening in Caveolin-1 Deficiency-Induced Pulmonary Artery Hypertension in Mice
Nächster Artikel Radiofrequency Ablation Alters the Microstructural Organization of Healthy and Enzymatically Digested Porcine Mitral Valves

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Metadaten
Titel
Effects of Red Blood Cell Sickling on Right Ventricular Afterload in vivo
verfasst von
D. A. Schreier
T. A. Hacker
D. M. Tabima
M. O. Platt
N. C. Chesler
Publikationsdatum
14.10.2020
Verlag
Springer US
Erschienen in
Experimental Mechanics / Ausgabe 1/2021
Print ISSN: 0014-4851
Elektronische ISSN: 1741-2765
DOI
https://doi.org/10.1007/s11340-020-00669-3

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