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Experimental Mechanics
Erschienen in: Experimental Mechanics 1/2021

14.10.2020 | Sp Iss: Experimental Advances in Cardiovascular Biomechanics

Arterial Wall Stiffening in Caveolin-1 Deficiency-Induced Pulmonary Artery Hypertension in Mice

verfasst von: J. Moreno, D. Escobedo, C. Calhoun, C. Jourdan Le Saux, H. C. Han

Erschienen in: Experimental Mechanics | Ausgabe 1/2021

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Abstract

Background

Pulmonary artery hypertension (PAH) is a complex disorder that can lead to right heart failure. The generation of caveolin-1 deficient mice (CAV-1−/−) has provided an alternative genetic model to study the mechanisms of pulmonary hypertension. However, the vascular adaptations in these mice have not been characterized.

Objective

To determine the histological and functional changes in the pulmonary and carotid arteries in CAV-1−/− induced PAH.

Methods

Pulmonary and carotid arteries of young (4–6 months old) and mature (9–12 months old) CAV-1−/− mice were tested and compared to normal wild type mice.

Results

Artery stiffness increases in CAV-1−/− mice, especially the circumferential stiffness of the pulmonary arteries. Increases in stiffness were quantified by a decrease in circumferential stretch and transition strain, increases in elastic moduli, and an increase in total strain energy at physiologic strains. Changes in mechanical properties for the pulmonary artery correlated with increased collagen content while changes in the carotid artery correlated with decreased elastin content.

Conclusions

We demonstrated that an increase in artery stiffness is associated with CAV-1 deficiency-induced pulmonary hypertension. These results improve our understanding of arterial remodeling in PAH.
Vorheriger Artikel The Association Between Curvature and Rupture in a Murine Model of Abdominal Aortic Aneurysm and Dissection
Nächster Artikel Effects of Red Blood Cell Sickling on Right Ventricular Afterload in vivo

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Metadaten
Titel
Arterial Wall Stiffening in Caveolin-1 Deficiency-Induced Pulmonary Artery Hypertension in Mice
verfasst von
J. Moreno
D. Escobedo
C. Calhoun
C. Jourdan Le Saux
H. C. Han
Publikationsdatum
14.10.2020
Verlag
Springer US
Erschienen in
Experimental Mechanics / Ausgabe 1/2021
Print ISSN: 0014-4851
Elektronische ISSN: 1741-2765
DOI
https://doi.org/10.1007/s11340-020-00666-6

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