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2022 | OriginalPaper | Buchkapitel

Electrochemotherapy Effectiveness Loss Due to Electrode Bending: An In Silico and In Vitro Study

verfasst von : D. L. L. S. Andrade, J. R. da Silva, R. Guedert, G. B. Pintarelli, J. A. Berkenbrock, S. Achenbach, D. O. H. Suzuki

Erschienen in: XXVII Brazilian Congress on Biomedical Engineering

Verlag: Springer International Publishing

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Abstract

In electrochemotherapy, needle electrodes can be used to apply electric fields in biological tissues to catalyze chemotherapy drug effect. Electrode bending, which is not entirely unavoidable, may affect the capacity of covering the entire tumor mass by insufficiently high electric fields. This paper aims to study how electrode needles misplacement affect the effectiveness of EQT, using in silico and in vitro experiments to analyze inwards and outwards bending. We observed an electric current increase at inwards bending. On the other hand, the electric field distribution is disturbed when they bent outwards. Both cases may induce treatment effectiveness loss. Based on those results, it is recommended to avoid usage of electrodes with mechanical deformations during electrochemotherapy treatments.

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Miklavčič D, Mali B, Kos B et al (2014) Electrochemotherapy: from the drawing board into medical practice. Biomed Eng Online 13:29. https://doi.org/10.1186/1475-925X-13-29CrossRef

Cemazar M, Tamzali Y, Sersa G et al (2008) Electrochemotherapy in veterinary oncology. J Vet Intern Med 22:826–831. https://doi.org/10.1111/j.1939-1676.2008.0117.xCrossRef

Suzuki DOH, Berkenbrock JA, de Oliveira KD et al (2017) Novel application for electrochemotherapy: immersion of nasal cavity in dog. Artif Organs 41:767–773. https://doi.org/10.1111/aor.12858CrossRef

Suzuki DOH, Berkenbrock JA, Frederico MJS et al (2018) Oral mucosa model for electrochemotherapy treatment of dog mouth cancer: ex vivo, in silico, and in vivo experiments. Artif Organs 42:297–304. https://doi.org/10.1111/aor.13003CrossRef

Esmaeili N, Friebe M (2019) Electrochemotherapy: a review of current status, alternative igp approaches, and future perspectives. J Healthc Eng 2019:1–11. https://doi.org/10.1155/2019/2784516CrossRef

Campana LG, Edhemovic I, Soden D et al (2019) Electrochemotherapy—Emerging applications technical advances, new indications, combined approaches, and multi-institutional collaboration. Eur J Surg Oncol 45:92–102. https://doi.org/10.1016/j.ejso.2018.11.023CrossRef

Cemazar M, Sersa G (2019) Recent Advances in Electrochemotherapy. Bioelectricity 1:204–213. https://doi.org/10.1089/bioe.2019.0028CrossRef

Mir LM, Gehl J, Sersa G et al (2006) Standard operating procedures of the electrochemotherapy: instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the CliniporatorTM by means of invasive or non-invasive electrodes. Eur J Cancer Suppl 4:14–25. https://doi.org/10.1016/j.ejcsup.2006.08.003CrossRef

Gehl J, Sersa G, Matthiessen LW et al (2018) Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases. Acta Oncol (Madr) 57(3):1–9. https://doi.org/10.1080/0284186X.2018.1454602CrossRef

10.

Yarmush ML, Golberg A, Serša G et al (2014) Electroporation-based technologies for medicine: principles, applications, and challenges. Annu Rev Biomed Eng 16:295–320. https://doi.org/10.1146/annurev-bioeng-071813-104622CrossRef

11.

Berkenbrock JA, Machado RG, Suzuki DOH (2018) Electrochemotherapy effectiveness loss due to electric field indentation between needle electrodes: a numerical study. J Healthc Eng 2018:1–8. https://doi.org/10.1155/2018/6024635CrossRef

12.

Pintarelli GB, Berkenbrock JA, Rassele A et al (2019) Computer simulation of commercial conductive gels and their application to increase the safety of electrochemotherapy treatment. Med Eng Phys 74:99–105. https://doi.org/10.1016/j.medengphy.2019.09.016CrossRef

13.

Corovic S, Lackovic I, Sustaric P et al (2013) Modeling of electric field distribution in tissues during electroporation. Biomed Eng Online 12:16. https://doi.org/10.1186/1475-925X-12-16CrossRef

14.

Zupanic A, Kos B, Miklavcic D (2012) Treatment planning of electroporation-based medical interventions: electrochemotherapy, gene electrotransfer and irreversible electroporation. Phys Med Biol 57:5425–5440. https://doi.org/10.1088/0031-9155/57/17/5425CrossRef

15.

Groselj A, Kos B, Cemazar M et al (2015) Coupling treatment planning with navigation system: a new technological approach in treatment of head and neck tumors by electrochemotherapy. Biomed Eng Online 14:S2. https://doi.org/10.1186/1475-925X-14-S3-S2CrossRef

16.

Vera-Tizatl AL, Kos B, Miklavcic D et al (2017) Investigation of numerical models for planning of electrochemotherapy treatments of invasive ductal carcinoma. In: 2017 Global Medical Engineering Physics Exchanges/Pan American Health Care Exchanges (GMEPE/PAHCE). IEEE, pp 1–6

17.

Ivorra A, Mir LM, Rubinsky B (2009) Electric field redistribution due to conductivity changes during tissue electroporation: experiments with a simple vegetal model. IFMBE Proc 25:59–62. https://doi.org/10.1007/978-3-642-03895-2-18CrossRef

18.

Berkenbrock JA, Pintarelli GB, Júnior ADCA, Suzuki DOH (2019) Verification of electroporation models using the potato tuber as in vitro simulation. J Med Biolog Eng 39(2):224–229.https://doi.org/10.1007/s40846-018-0408

19.

Garcia PA, Davalos RV, Miklavcic D (2014) A numerical investigation of the electric and thermal cell kill distributions in electroporation-based therapies in tissue. PLoS ONE 9:e103083. https://doi.org/10.1371/journal.pone.0103083CrossRef

20.

van den Bos W, Scheffer HJ, Vogel JA et al (2016) Thermal energy during irreversible electroporation and the influence of different ablation parameters. J Vasc Interv Radiol 27:433–443. https://doi.org/10.1016/j.jvir.2015.10.020CrossRef

21.

Oey I, Faridnia F, Leong SY et al (2016) Determination of pulsed electric fields effects on the structure of potato tubers. In: Miklavcic D (ed) Handbook of electroporation. Springer International Publishing, Cham, pp 1–19

22.

Miklavčič D, Pavšelj N, Hart FX (2006) Electric properties of tissues. Wiley Encycl Biomed, EngCrossRef

23.

Cl G (2019) Non-parallellism of needles in electroporation: 3D computational model and experimental analysis. COMPEL Int J Comput Math Electr Electron Eng 38:348–361. https://doi.org/10.1108/COMPEL-04-2018-0189CrossRef

24.

Staal LG, Gilbert R (2011) Generators and applicators: equipment for electroporation BT—clinical aspects of electroporation. In: Kee ST, Gehl J, Lee EW (eds) Springer. New York, NY, New York, pp 45–65

25.

Bertacchini C (2017) Cliniporator: medical electroporation of tumors. Handbook of electroporation. Springer International Publishing, Cham, pp 1–36

Titel: Electrochemotherapy Effectiveness Loss Due to Electrode Bending: An In Silico and In Vitro Study
verfasst von: D. L. L. S. Andrade
J. R. da Silva
R. Guedert
G. B. Pintarelli
J. A. Berkenbrock
S. Achenbach
D. O. H. Suzuki
Verlag: Springer International Publishing
Buch: XXVII Brazilian Congress on Biomedical Engineering
Print ISBN: 978-3-030-70600-5

Electronic ISBN: 978-3-030-70601-2

Copyright-Jahr: 2022
DOI: https://doi.org/10.1007/978-3-030-70601-2_166

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