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01.03.2022 | Original Research

Electrospun cellulose acetate wound dressings loaded with Pramipexole for diabetic wound healing: an in vitro and in vivo study

verfasst von: Changming Tan, Zhaoshun Yuan, Feng Xu, Xia Xie

Erschienen in: Cellulose | Ausgabe 6/2022

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Abstract

In the current study, a Pramipexole-loaded wound dressing was produced via electrospinning of cellulose acetate solution. Pramipexole was added to cellulose acetate solution at 3, 5, and 10% w/w concentrations and then electrospun. The produced wound dressings were studied regarding their physicochemical and biological properties. Results of cell viability assay and cytoprotection studies showed that cellulose acetate wound dressings containing 3% w/w Pramipexole had significantly higher cell viability compared with other concentrations. The wound healing potential of dressings incorporated with 3% drug was studied in a rat model of diabetic wound. Study showed that the cellulose acetate/3% Pramipexole scaffolds had significantly higher percentage of wound closure, epithelial thickness, and collagen deposition compared with drug-free dressings and control group. Gene expression study showed that the drug-loaded wound dressings could reduce oxidative stress and alleviate inflammation at significantly higher extent compared with other groups.

Vorheriger Artikel Cellulose-g-tetraethylenepentamine dual-function imprinted polymers selectively and effectively adsorb and remove 4-nitrophenol and Cr(VI)

Nächster Artikel Semi-interpenetrated polymer networks based on modified cellulose and starch as gel polymer electrolytes for high performance lithium ion batteries

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Titel: Electrospun cellulose acetate wound dressings loaded with Pramipexole for diabetic wound healing: an in vitro and in vivo study
verfasst von: Changming Tan
Zhaoshun Yuan
Feng Xu
Xia Xie
Publikationsdatum: 01.03.2022
Verlag: Springer Netherlands
Erschienen in: Cellulose / Ausgabe 6/2022
Print ISSN: 0969-0239
Elektronische ISSN: 1572-882X
DOI: https://doi.org/10.1007/s10570-022-04466-0

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