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Quality of Life Research
Erschienen in: Quality of Life Research 7/2020

27.03.2020

Evaluation of quality of life and its influencing factors after transplantation of leukemia patients based on SF-36 score: a cohort study

verfasst von: Wenjun Xie, Xiaoyu Zhang, Jiao Wang, Jinghui Zhang, Jie Liu, Bei Wang, Wei Guan, Huijuan Zhang, Li Xu, Guiying Liu, Sizhou Feng, Changping Li, Mingzhe Han

Erschienen in: Quality of Life Research | Ausgabe 7/2020

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Abstract

Purpose

The aim of this study is to clarify the short-term quality of life (QoL) of acute leukemia (AL) patients early after stem cell transplantation (SCT) and related predictors of QoL recovery.

Methods

We investigated adult AL patients who underwent SCT at the Institute of Hematology and Blood Diseases Hospital after transplantation. Physical/functional and emotional/mental recovery were evaluated using the Short Form 36 (SF-36) questionnaire to identify its trajectory as well as related predictors for the physical component summary (PCS) and mental component summary (MCS). The score was also used to establish a QoL prediction model.

Results

A total of 326 AL patients responded to our QoL survey. The results revealed the profile of patient follow-up from 2013 to 2015. Along follow-up after transplantation, there was a significant increase in PCS (p = 0.139) and MCS (p = 0.122). On multivariate regression analysis, apart from follow-up, marriage, financial situation, employment situation, and history of chronic graft-versus-host disease (cGVHD) had clinical significance for both PCS and MCS. A prediction model for patient risk hierarchy estimation was further established. The logistic results revealed that the significant characteristics of patients with high PCS and high MCS were unmarried, without financial burden, reliable on drugs, and with history of acute graft-versus-host disease (aGVHD).

Conclusions

This well-established study enabled evaluation of the QoL of AL patients post-HSCT in China. The established prediction model could provide more indications and insights into improvement in quality of life for better medical interventions.
Vorheriger Artikel Socioeconomic burden and quality of life in meningioma patients
Nächster Artikel Predictive model of variables associated with health-related quality of life in patients with advanced chronic kidney disease receiving hemodialysis

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Metadaten
Titel
Evaluation of quality of life and its influencing factors after transplantation of leukemia patients based on SF-36 score: a cohort study
verfasst von
Wenjun Xie
Xiaoyu Zhang
Jiao Wang
Jinghui Zhang
Jie Liu
Bei Wang
Wei Guan
Huijuan Zhang
Li Xu
Guiying Liu
Sizhou Feng
Changping Li
Mingzhe Han
Publikationsdatum
27.03.2020
Verlag
Springer International Publishing
Erschienen in
Quality of Life Research / Ausgabe 7/2020
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-020-02444-2

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