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Polymer Bulletin
Erschienen in: Polymer Bulletin 9/2015

01.09.2015 | Original Paper

Facile synthesis of boronic acid-functionalized nanocarriers for glucose-triggered caffeic acid release

verfasst von: Mehmet Ulasan, Emine Yavuz, Yunus Cengeloglu, Mustafa Selman Yavuz

Erschienen in: Polymer Bulletin | Ausgabe 9/2015

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Abstract

In this study, boronic acid-functionalized methacrylate-based nanoparticles were synthesized via surfactant-free emulsion polymerization in one pot. Uniform (polydispersity index <0.05) sub-100 nm nanoparticles were obtained. The changes of average hydrodynamic diameter and polydispersity index of nanoparticles against boronic acid content in total monomer and acetone percentage in the solvent mixture were investigated. Polymerization kinetics in terms of monomer conversion rate was monitored by gravimetric method. The nanoparticles were characterized by scanning electron microscopy and dynamic light scattering. The boron content in the nanoparticles was confirmed by electron-dispersive X-ray spectroscopy. Further, the nanoparticles were combined with caffeic acid. Caffeic acid carrying nanoparticles were titrated against glucose or fructose in which caffeic acid is released by the displacement reaction in a controlled manner. The displacement of caffeic acid and glucose was monitored by UV–visible spectral change. Furthermore, in vitro biocompatibility of nanoparticles was tested in NIH-3T3 cells, which resulted no significant toxicity effect on the cells.
Nächster Artikel Cu2+ adsorption onto ion-imprinted composite hydrogels: thermodynamics and mechanism studies

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Metadaten
Titel
Facile synthesis of boronic acid-functionalized nanocarriers for glucose-triggered caffeic acid release
verfasst von
Mehmet Ulasan
Emine Yavuz
Yunus Cengeloglu
Mustafa Selman Yavuz
Publikationsdatum
01.09.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Polymer Bulletin / Ausgabe 9/2015
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-015-1393-5

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