nach oben

Erschienen in:

2009 | OriginalPaper | Buchkapitel

6. Fructan Prebiotics Derived from Inulin

verfasst von : Douwina Bosscher

Erschienen in: Prebiotics and Probiotics Science and Technology

Verlag: Springer New York

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config

KI-gestützte Suche

Aus

Abstract

Inulin, as well as the shorter form oligofructose, is a nondigestible carbohydrate (fructan) that has been part of the daily food of mankind for centuries. Inulin-type fructans naturally occur in many edible plants as storage carbohydrates. They are present in leek, onion, garlic, wheat, chicory, artichoke, and banana. It is estimated that an average North American consumes about 1–4 g/day of inulin or oligofructose. In Western Europe, the average intake varies between 3 and 10 g/day. Occasionally, people can have higher intakes, e.g., after consuming a bowl of French onion soup, salsify dish, etc., and intakes can then exceed easily 10 g. This illustrates that via the normal diet some, and at certain times, all populations consume relatively high quantities of inulin-type fructans. It also follows that wheat, onion, and banana, and to a lesser extend garlic are the most important sources of inulin-type fructans in the diet. Although inulin-type fructans are nutritive substances and part of our daily diet, these compounds are currently not taken up in food composition tables.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Vorheriges Kapitel Mechanisms of Prebiotic Impact on Health

Nächstes Kapitel Galacto-Oligosaccharide Prebiotics

Abrams SA, Griffin IJ, Hawthorne KM, Ellis KJ (2007) Effect of prebiotic supplementation and calcium intake on body mass index. J Pediatr 151:293–298CrossRef

Abrams SA, Griffin IJ, Hawthorne KM, Liang L, Gunn SK, Darlington G, Ellis KJ (2005) A combination of prebiotic short- and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents. Am J Clin Nutr 82:471–476

Ananta E, Birkeland S-E, Corcoran B, Fitzgerald G, Hinz S, Klijn A, Mättö J, mercenier A, Nilsson U, Nyman M, O’Sullivan E, Parche S, Rautonen N, Ross RP, Saarela M, Stanton C, Stahl U, Suomalainen T, Vincken J-P, Virkajärvi I, Voragen F, Wesenfeld J, Wouters R, Knorr D (2004) Processing effects on the nutritional advancement of probiotics and prebiotics. Microb Ecol Health Dis 16:113–124CrossRef

Archer BJ, Johnson SK, Devereux HM, Baxter AL (2004) Effect of fat replacement by inulin or lupin-kernel on sausage patty acceptability, post-meal perceptions of satiety and food intake in men. Br J Nutr 91:591–599CrossRef

Bartosch S, Woodmansey EJ, Paterson JCM, McMurdo ET, Macfarlane GT (2005) Microbiological effects of consuming a synbiotic containing Bifidobacterium bifidum, Bifidobacterium lactis, and oligofructose in elderly persons, determined by real-time polymerase chain reaction and counting of viable bacteria. CID 40:28–37CrossRef

Belenguer A, Duncan SH, Calder AG, Holtrop G, Louis P, Lobley GE, Flint HJ (2006) Two routes of metabolic cross-feeding between Bifidobacterium adolescentis and butyrate-producing anaerobes from the human gut. Appl Environ Microbiol 72:3593–3599CrossRef

Benyacoub J, Rochat F, Saudan K-Y, Rochat I, Antille N, Cherbut C, von der Weid T, Schiffrin EJ, Blum S (2008) Feeding a diet containing a fructooligosaccharide mix can enhance Salmonella vaccine efficacy in mice. J Nutr 138:123–129

Bosscher D, Van Loo J, Franck A (2006a) Inulin and oligofructose as prebiotics in the prevention of intestinal infections and diseases. Nutr Res Rev 19:216–226CrossRef

Bosscher D, Van Loo J, Franck A (2006b) Inulin and oligofructose as functional ingredients to improve mineralization. Int Dairy J 16:1092–1097CrossRef

Brighenti F, Casiraghi MC, Canzi E, Ferrari A (1999) Effect of consumption of a ready-to-eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy male volunteers. Eur J Clin Nutr 53:726–733CrossRef

Buddington KK, Donahoo JB, Buddington RK (2002) Dietary oligofructose and inulin protect mice from enteric and systemic pathogens and tumor inducers. J Nutr 132:472–477

Bunout D, Barrera G, Hirsch S, Gattas V, Pia de la Maza M, Haschke F, Steenhout P, Klassen P, Hager C, Avendano M, Petermann M, Munoz C (2004) Effects of a nutritional supplement on the immune response and cytokine production in free-living Chilean elderly. J Parenter Enteral Nutr 28:348–354CrossRef

Butel M, Catala I, Waligora-Dupriet A, Taper H, Tessedre A, Durao J, Szylit O (2001) Protective effect of dietary oligofructose against cecitis induced by clostridia in gnotobiotic quails. Microb Ecol Health Dis 13:166–172CrossRef

Butel MJ, Roland N, Hibert A, Popot F, Favre A, Tessedre AC, Bensaada M, Rimbault A, Szylit O (1998) Clostridial pathogenicity in experimental necrotising enterocolitis in gnotobiotic quails and protective role of bifidobacteria. J Med Microbiol 47(5):391–399CrossRef

Cani P, Daubioul C, Reusens B, Remacle C, Catillon G, Delzenne N (2005b) Involvement of endogeneous glucagon-like peptide-1(7–36) amide on glycemia-lowering effect of oligofructose in streptozotocin-treated rats. J Endocrin 185:457–465CrossRef

Cani P, Dewever C, Delzenne M (2004) Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats. Br J Nutr 92:521–526CrossRef

Cani PD, Hoste S, Guiot Y, Delzenne NM (2007a) Dietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats. Br J Nutr 98:32–37CrossRef

Cani P, Joly E, Hormans Y, Delzenne N (2006a) Oligofructose promotes satiety in healthy human: a pilot study. Eur J Clin Nutr 60:567–572CrossRef

Cani P, Knauf C, Iglesias M, Drucker D, Delzenne N, Burcelin R (2006b) Improvement of glucose tolerance and hepatic insulin secretion by oligofructose requires a functional glucagon-like peptide 1 receptor. Diabetes 55:1484–1490CrossRef

Cani PD, Neyrinck AM, Fava F, Knauf C, Burcelin RG, Tuohy KM, Gibson GR, Delzenne NM (2007b) Selective increases of bifidobacteria in gut microflora improve high-fat-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologica 50:2374–2383CrossRef

Cani P, Neyrinck A, Maton N, Delzenne N (2005a) Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like peptide-1. Obes Res 13:1000–1007CrossRef

Casellas F, Borruel N, Torrejón A, Varela E, Antolin M, Guarner F, Malagelada J-R (2007). Oral oligofructose-enriched inulin supplementation in acute colitis is well tolerated and associated with lower faecal calprotectin. Aliment Pharmacol Ther 25:1061–1067CrossRef

Cherbut C, Michel C, Lecannu G (2003) The prebiotic characteristics of fructooligosaccharides are necessary for reduction of TNBS-induced colitis in rats. J Nutr 133:21–27

Daubioul C, Rousseau N, Demeure R, Gallez B, Taper H, Declerck B, Delzenne N (2002) Dietary fructans, but not cellulose, decrease triglyceride accumulation in the liver of obese Zucker fa/fa rats. J Nutr 132:967–973

Davidson MH, Maki KC (1999) Effects of dietary inulin on serum lipids. J Nutr 129:1474S–1477S

Delzenne N, Aertssens J, Verplaetse H, Roccaro M, Roberfroid M (1995) Effect of fermentable fructo-oligosaccharides on mineral, nitrogen and energy digestive balance in the rat. Life Sci 57:1579–1587CrossRef

Den Hond E, Geypens B, Ghoos Y (2000) Effect of high performance chicory inulin on constipation. Nutr Res 20:731–736CrossRef

Duncan SH, Holtrop G, Lobley GE, Calder AG, Stewart CS, Flint HJ (2004) Contribution of acetate to butyrate formation by human faecal bacteria. Br J Nutr 91:915–923CrossRef

Falony G, Vlachou A, Verbrugge K, De Vuyst L (2006) Cross-feeding between Bifidobacterium longum BB536 and acetate-converting, butyrate-producing colon bacteria during growth on oligofructose. Appl Environ Microbiol 72:7835–7841CrossRef

Firmansyah A, Pramita G, Fassler C, Haschke F, Link-Amster H (2001) Improved humoral immune response to measles vaccine in infants receiving infant cereal with fructooligosaccharides. J Pediatr Gastroenterol Nutr 31:A521

Fisberg M, Maulen I, Vasquez E, Garcia J, Comer GM, Alarcon PA (2000) Effect of oral supplementation with and without synbiotics on catch-up growth in preschool children. J Pediatr Gastroenterol Nutr 31:A521

Franck A (2002) Technological functionality of inulin and oligofructose. Br J Nutr 87:S287–S291CrossRef

Fukushima A, Ohta A, Sakai K, Sakuma K (2005) Expression of calbindin-D9k, VDR and Cdx-2 Messenger RNA in the process by which fructo-oligosaccharides increase calcium absorption in rats. J Nutr Sci Vitaminol 51:426–432

Furrie E, Macfarlane S, Kennedy A, Cummings JH, Walsh SV, O’Neil DA, Macfarlane GT (2005) Synbiotic therapy (Bifidobacterium longum/Synergy1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomized controlled pilot trial. Gut 54:242–249CrossRef

Gibson GR, Beatty ER, Cummings J (1995a) Selective fermentation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 108:975–982CrossRef

Gibson GR, Probert HM, Van Loo J, Rastall RA Roberfroid MB (2004) Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutr Res Rev 17:259–275CrossRef

Gibson GR, Roberfroid MB (1995b) Dietary modulation of the human colonic microbiota - Introducing the concept of prebiotics. J Nutr 125:1401–1412

Griffin IJ, Hicks PMD, Heaney RP, Abrams SA (2003) Enriched chicory inulin increases calcium absorption mainly in girls with lower calcium absorption. Nutr Res 23:901–909CrossRef

Hoebregs H (1997) Fructans in foods and food products, ion-exchange chromatographic method: collaborative study. J AOAC 5:80–102

Hoentjen F, Welling GW, Harmsen HJM, Zhang X, Snart J, Tannock GW, Lien K, Churchill TA, Lupicki M, Dieleman LA (2005) Reduction of colitis by prebiotics in HLA-B27 transgenic rats is associated with microflora changes and immunomodulation. Inflamm Bowel Dis 11:977–985CrossRef

Holloway L, Moynihan S, Abrams SA, Kent K, Hsu AR, Friedlander AL (2007) Effects of oligofructose-enriched inulin on intestinal absorption of calcium and magnesium and bone turnover markers in postmenopausal women. Br J Nutr 97:365–372CrossRef

Jackson KG, Taylor GR, Clohessy AM, Williams CM (1999) The effect of the daily intake of inulin on fasting lipid, insulin and glucose concentrations in middle-aged men and women. Br J Nutr 82:23–30

Kleessen B, Sykura B, Zunft H-J, Blaut M (1997) Effects of inulin and lactose on feval microbiota, microbial activity, and bowel habit in elderly constipated persons. Am J Clin Nutr 65:1397–1402

Klinder A, Förster A, Caderni G, Femia AP, Pool-Zobel NL (2004) Fecal water genotoxicity is predictice of tumor-preventive activities by inulin-like oligofructoses, probiotics (Lactobacillus rhamnosus and Bifidobacterium lactis), and their synbiotic combination. Nutr Cancer 49:144–155CrossRef

Kok NN, Morgan LM, Williams CM, Roberfroid MB, Thissen JP, Delzenne NM (1998) Insulin, glucagon-like peptide 1, glucose-dependent insulinotropic polypeptide and insulin-like growth factor I as putative mediators of the hypolipidemic effect of oligofructose in rats. J Nutr 128:1099–1103

Langlands SJ, Hopkins MJ, Coleman N, Cummings JH (2004) Prebiotic carbohydrates modify the mucosa associated microflora of the human large bowel. Gut 53:1610–1616CrossRef

Lesniewska V, Rowland I, Laerke HN, Grant G, Naughton PJ (2006) Relationship between dietary-induced changes in intestinal commensal microflora and duodenojejunal myoelectric activity monitored by radiotelemetry in the rat in vivo. Exp Physiology 91:229–237CrossRef

Lewis S, Burmeister S, Brazier J (2005) Effect of the prebiotic oligofructose on relapse of Clostridium difficile-associated diarrhea: a randomized, controlled study. Clin Gastroenterol Hepatol 3:442–448CrossRef

Ley et al. (2006) Human gut microbes associated with obesity. Nature 444:1022–1023CrossRef

Lindsay JO, Whelan K, Stagg AJ, Gobin P, Al-Hassi HO, Raiment N, Kamm MA, Knight SC, Forbes A (2006) Clinical, microbiological and immunological effects of fructo-oligosaccharides in patients with Crohn’s disease. Gut 55:348–355CrossRef

Mathey J, Puel C, Kati-Coulibaly S, Bennetau-Pelissero C, Lebecque P, Horcajada MN, Coxam V (2004) Fructo-oligosaccharides maximize bone-spearing effects of soy isoflavone-enriched diet in ovariectomized rat. Calcif Tissue Int 75:169–179CrossRef

Oli MW, Petschow BW, Buddington RK (1998) Evaluation of fructooligosaccharide supplementation of oral electrolyte solutions for treatment of diarrhea: Recovery of the intestinal bacteria. Dig Dis Sci 43:138–147CrossRef

Orrhage K, Sjostedt S, Nord CE (2000) Effects of supplements with lactic acid bacteria. J Antimicrob Chemother 46:603–611CrossRef

Osman N, Adawi D, Molin G, Ahrne S, Berggren A, Jeppsson B (2006) Bifidobacterium infantis strain with and without a combination of oligofructose-enriched inulin (OFI) attenuate inflammation in DSS-induced colitis in rats. BMC Gastroenterology 6:31 (online publication)CrossRef

Paineau D, Payen F, Panserieu S, Coulombier G, Sobaszek A, Lartigau I, Brabet M, Galmiche J-P, Tripodi D, Sacher-Huvelin S, Chapalain V, Zourabichvilli O, Respondek F, Wagner A, Bornet FRJ (2008) The effects of regular consumption of short-chain fructo-oligosaccharides on digestive comport of subjects with minor functional bowel disorders. Br J Nutr 13:311–318

Rafter J, Bennett M, Caderni G, Clune Y, Hughes R, Karlsson PC, Klinder A, O’ Riordan M, O’Sullivan GC, Pool-Zobel B, Rechkemmer G, Roller M, Rowland I, Salvadori M, Thijs H, Van Loo J, Watzl B, Collins JK (2007) Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients. Am J Clin Nutr 85:488–496

Rao A (2001) The prebiotic properties of oligofructose at low intake levels. Nutr Res 21:843–848CrossRef

Raschka L, Daniel H (2005) Mechanisms underlying the effects of inulin-type fructans on calcium absorption in the large intestine of rats. Bone 37:728–735CrossRef

Rault-Nania MH, Gueux E, Demougeot C, Demigne C, Rock E, Mazur A (2006) Inulin attenuates atherosclerosis in apolipoprotein E-deficient mice. Br J Nutr 96:840–844CrossRef

Roberfroid MB, Cumps J, Devogelaer JP (2002) Dietary chicory inulin increases whole-body bone mineral density in growing male rats. J Nutr 132:3599–3602

Roberfroid M, Gibson G, Delzenne N (1993) Biochemistry of oligofructose, a non-digestible fructooligosaccharide: an approach to estimate its caloric value. Nutr Rev 51:137CrossRef

Roller M, Femia AP, Caderni G, Rechkemmer G, Watzl B (2004) Intestinal immunity of rats with colon cancer is modulated by oligofructose-enriched inulin combined with Lactobacillus rhamnosus and Bifidobacterium lactis. Br J Nutr 92:931–938CrossRef

Saavedra J, Tschernia A (2002) Human studies with probiotics and prebiotics: clinical implications. Br J Nutr 87:S241–S246CrossRef

Sauer J, Richter KK, Pool-Zobel BL (2007) Products formed during fermentation of the prebiotic inulin with human gut flora enhances expression of biotransformation genes in human primary colon cells. Br J Nutr 97:928–937CrossRef

Scholtens PAM, Alles MS, Willemsen LEM, van der Braak C, Bindels JG, Boehm G, Govers MJAP (2006) Dietary fructo-oligosaccharides in healthy adults do not negatively affect faecal cytotoxicity: a randomised, double-blind, placebo-controlled crossover trial. Br J Nutr 95:1143–1149CrossRef

Scholz-Ahrens KE, Acil Y, Schrezenmeir J (2002) Effect of oligofructose or dietary calcium on repeated calcium and phosphorus balances, bone mineralization and trabecular structure in ovariectomized rats. Br J Nutr 88:365–377CrossRef

Steegmans M, Iliaens S, Hoebregs H (2004) Enzymatic, spectrophotometric determination of glucose, fructose, sucrose and inulin/oligofructose in foods. J AOAC Int 87:1200–1207

Ten Bruggencate SJ, Bovee-Oudenhoven IM, Lettink-Wissink ML, Katan MB, Van der Meer R (2004) Dietary fructo-oligosaccharides and inulin decrease resistance of rats to Salmonella: protective role of calcium. Gut 53:530–535CrossRef

Tuohy KM (2001) A human volunteer study on the prebiotic effects of HP-inulin-faecal bacteria enumerated using fluorescent in situ hybridisation (FISH). Anaerobe 7:113–118CrossRef

Van Loo J, Coussement P, De Leenheer L, Hoebregs H, Smits G (1995) On the presence of inulin and oligofructose as natural ingredients in the Western diet. Crit Rev Food Sci Nutr 35:525–552CrossRef

Verghese M, Walker LT, Shackelford L, Chawan CB (2005) Inhibitory effects of nondigestible carbohydrates of different chain lengths on azoxymethane-induced aberrant crypt foci in Fisher 344 rats. Nutr Res 25:859–868CrossRef

Videla S, Vilaseca J, Antolin M, Garcia-Lafuente A, Guarner F, Crespo E, Casalots J, Salas A, Malagelada JR (2001) Dietary inulin improves distal colitis induced by dextran sodium sulfate in the rat. Am J Gastroenterol 96:1486–1493CrossRef

Waligora-Dupriet A-J, Campeotto F, Nicolis I, Bonet A, Soulaines P, Dupont C, Butel M-J (2007) Effect of oligofructose supplementation on gut microflora and well-being in young children attending a day care centre. Int J Food Microbiol 113:108–113CrossRef

Welters CF, Heineman E, Thunnissen FB, van den Bogaard AE, Soeters PB, Baeten CG (2002) Effect of dietary inulin supplementation on inflammation of pouch mucosa in patients with an ileal pouch-anal anastomosis. Dis Colon Rectum 45:621–627CrossRef

Whelan K, Efthymiou L, Judd PA, Preedy VR, Taylor MA (2006) Appetite during consumption of enteral formula as a sole source of nutrition: the effect of supplementing pea-fibre and fructo-oligosaccharides. Br J Nutr 96:350–356CrossRef

Yasuda K, Roneker K, Miller D, Welch R, Lei XG (2006) Supplemental dietary inulin affects the bioavailability of iron in corn and soybean meal to young pigs. J Nutr 136:3033–3038

Zafar TA, Weaver CM, Zhao Y, Martin BR, Wastney ME (2004) Nondigestible oligosaccharides increase calcium absorption and suppress bone resorption in ovariectomized rats. J Nutr 134:399–402

Zunft H-JF, Hanisch C, Mueller S, Koebnick C, Blaut M, Doré J (2004) Synbiotic containing Bifidobacterium animalis and inulin increases stool frequency in elderly healthy people. Asia Pac J Clin Nutr 13:112

Titel: Fructan Prebiotics Derived from Inulin
verfasst von: Douwina Bosscher
Verlag: Springer New York
Buch: Prebiotics and Probiotics Science and Technology
Print ISBN: 978-0-387-79057-2

Electronic ISBN: 978-0-387-79058-9

Copyright-Jahr: 2009
DOI: https://doi.org/10.1007/978-0-387-79058-9_6

Premium Partner

Marktübersichten

Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen.

Zur Marktübersicht