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Erschienen in:

2012 | OriginalPaper | Buchkapitel

Harnessing Cell–Biomaterial Interactions for Osteochondral Tissue Regeneration

verfasst von : Kyobum Kim, Diana M. Yoon, Antonios G. Mikos, F. Kurtis Kasper

Erschienen in: Tissue Engineering III: Cell - Surface Interactions for Tissue Culture

Verlag: Springer Berlin Heidelberg

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Abstract

Articular cartilage that is damaged or diseased often requires surgical intervention to repair the tissue; therefore, tissue engineering strategies have been developed to aid in cartilage regeneration. Tissue engineering approaches often require the integration of cells, biomaterials, and growth factors to direct and support tissue formation. A variety of cell types have been isolated from adipose, bone marrow, muscle, and skin tissue to promote cartilage regeneration. The interaction of cells with each other and with their surrounding environment has been shown to play a key role in cartilage engineering. In tissue engineering approaches, biomaterials are commonly used to provide an initial framework for cell recruitment and proliferation and tissue formation. Modifications of the properties of biomaterials, such as creating sites for cell binding, altering their physicochemical characteristics, and regulating the delivery of growth factors, can have a significant influence on chondrogenesis. Overall, the goal is to completely restore healthy cartilage within an articular cartilage defect. This chapter aims to provide information about the importance of cell–biomaterial interactions for the chondrogenic differentiation of various cell populations that can eventually produce functional cartilage matrix that is indicative of healthy cartilage tissue.

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Vorheriges Kapitel Studying Cell–Surface Interactions In Vitro: A Survey of Experimental Approaches and Techniques

Nächstes Kapitel Interaction of Cells with Decellularized Biological Materials

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Titel: Harnessing Cell–Biomaterial Interactions for Osteochondral Tissue Regeneration
verfasst von: Kyobum Kim
Diana M. Yoon
Antonios G. Mikos
F. Kurtis Kasper
Verlag: Springer Berlin Heidelberg
Buch: Tissue Engineering III: Cell - Surface Interactions for Tissue Culture
Print ISBN: 978-3-642-28281-2

Electronic ISBN: 978-3-642-28282-9

Copyright-Jahr: 2012
DOI: https://doi.org/10.1007/10_2011_107

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