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Erschienen in:

2013 | OriginalPaper | Buchkapitel

11. Hydrogels with Rapid Response to Glucose Concentration Change at Physiological Temperature

verfasst von : Liang-Yin Chu, Rui Xie, Xiao-Jie Ju, Wei Wang

Erschienen in: Smart Hydrogel Functional Materials

Verlag: Springer Berlin Heidelberg

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Abstract

In this chapter, a new type of glucose-responsive hydrogel with rapid response to blood glucose concentration change at physiological temperature is introduced. The hydrogel contains 3-acrylamidophenylboronic acid (AAPBA) with phenylboronic acid (PBA) groups as glucose sensors and thermo-responsive poly(N-isopropylacrylamide) (PNIPAM) as actuators. The response rate of the hydrogel to the change of environmental glucose concentration is significantly enhanced by introducing grafted poly(NIPAM-co-AAPBA) (PNA) side chains onto cross-linked PNA networks for the first time. The synthesized comb-type PNA hydrogels show satisfactory equilibrium glucose-responsive properties. Meanwhile, the hydrogels exhibit much faster response rate to glucose concentration change than normal type of cross-linked PNA hydrogels at physiological temperature. Such glucose-responsive hydrogels with rapid response rate are highly attractive for developing glucose-responsive sensors and self-regulated drug delivery systems.

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Titel: Hydrogels with Rapid Response to Glucose Concentration Change at Physiological Temperature
verfasst von: Liang-Yin Chu
Rui Xie
Xiao-Jie Ju
Wei Wang
Verlag: Springer Berlin Heidelberg
Buch: Smart Hydrogel Functional Materials
Print ISBN: 978-3-642-39537-6

Electronic ISBN: 978-3-642-39538-3

Copyright-Jahr: 2013
DOI: https://doi.org/10.1007/978-3-642-39538-3_11

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