Skip to main content

2017 | OriginalPaper | Buchkapitel

Imaging Genetics: Information Fusion and Association Techniques Between Biomedical Images and Genetic Factors

verfasst von : Dongdong Lin, Vince D. Calhoun, Yu-Ping Wang

Erschienen in: Health Informatics Data Analysis

Verlag: Springer International Publishing

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

The development of advanced medical imaging technologies and high-throughput genomic measurements has enhanced our understanding of their interplay as well as their relationship with human behavior. In this chapter, we review the recent work of fusing imaging and genetic data for the correlative and association analysis as well as the diverse statistical models in these studies from univariate to multivariate methods. We also discuss future directions and challenges in integrative analysis of imaging and genetic data and finally give an example of parallel independent component analysis (ICA) in an imaging genetic study of schizophrenia.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Literatur
1.
Zurück zum Zitat L. Shen et al., Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers. Brain Imaging Behav. 1–25 (2013) L. Shen et al., Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers. Brain Imaging Behav. 1–25 (2013)
2.
Zurück zum Zitat I.I. Gottesman, T.D. Gould, The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry 160, 636–645 (2003) I.I. Gottesman, T.D. Gould, The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry 160, 636–645 (2003)
3.
Zurück zum Zitat A. Meyer-Lindenberg, D.R. Weinberger, Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat. Rev. Neurosci. 7, 818–827 (2006)CrossRef A. Meyer-Lindenberg, D.R. Weinberger, Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat. Rev. Neurosci. 7, 818–827 (2006)CrossRef
4.
Zurück zum Zitat A. Meyer-Lindenberg, The future of fMRI and genetics research. Neuroimage 62, 92–1286 (2012)CrossRef A. Meyer-Lindenberg, The future of fMRI and genetics research. Neuroimage 62, 92–1286 (2012)CrossRef
5.
Zurück zum Zitat G. Northoff, Gene, brains, and environment—genetic neuroimaging of depression. Curr. Opin. Neurobiol. 23, 133–142 (2013)CrossRef G. Northoff, Gene, brains, and environment—genetic neuroimaging of depression. Curr. Opin. Neurobiol. 23, 133–142 (2013)CrossRef
6.
Zurück zum Zitat J.P. Andrawis et al., Effects of ApoE4 and maternal history of dementia on hippocampal atrophy. Neurobiol. Aging 33, 856–866 (2012)CrossRef J.P. Andrawis et al., Effects of ApoE4 and maternal history of dementia on hippocampal atrophy. Neurobiol. Aging 33, 856–866 (2012)CrossRef
7.
Zurück zum Zitat A.J. Ho et al., A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proc. Natl. Acad. Sci. 107, 8404–8409 (2010)CrossRef A.J. Ho et al., A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proc. Natl. Acad. Sci. 107, 8404–8409 (2010)CrossRef
8.
Zurück zum Zitat J.L. Stein et al., Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer’s disease. Neuroimage 51, 542–554 (2010)CrossRef J.L. Stein et al., Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer’s disease. Neuroimage 51, 542–554 (2010)CrossRef
9.
Zurück zum Zitat S.A. Melville et al., Multiple loci influencing hippocampal degeneration identified by genome scan. Ann. Neurol. 72, 65–75 (2012)CrossRef S.A. Melville et al., Multiple loci influencing hippocampal degeneration identified by genome scan. Ann. Neurol. 72, 65–75 (2012)CrossRef
10.
Zurück zum Zitat J.L. Stein et al., Voxelwise genome-wide association study (vGWAS). Neuroimage 53, 1160–1174 (2010)CrossRef J.L. Stein et al., Voxelwise genome-wide association study (vGWAS). Neuroimage 53, 1160–1174 (2010)CrossRef
11.
Zurück zum Zitat A. Leow et al., Inverse consistent mapping in 3D deformable image registration: its construction and statistical properties, in Information Processing in Medical Imaging (2005), pp. 493–503 A. Leow et al., Inverse consistent mapping in 3D deformable image registration: its construction and statistical properties, in Information Processing in Medical Imaging (2005), pp. 493–503
12.
Zurück zum Zitat Y. Benjamini, Y. Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. Roy. Stat. Soc. Ser. B (Methodol.), 289–300 (1995) Y. Benjamini, Y. Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. Roy. Stat. Soc. Ser. B (Methodol.), 289–300 (1995)
13.
Zurück zum Zitat L. Shen et al., Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: a study of the ADNI cohort. Neuroimage 53, 1051–1063 (2010)CrossRef L. Shen et al., Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: a study of the ADNI cohort. Neuroimage 53, 1051–1063 (2010)CrossRef
14.
Zurück zum Zitat J. Hoh et al., Trimming, weighting, and grouping SNPs in human case-control association studies. Genome Res. 11, 2115–2119 (2001)CrossRef J. Hoh et al., Trimming, weighting, and grouping SNPs in human case-control association studies. Genome Res. 11, 2115–2119 (2001)CrossRef
15.
Zurück zum Zitat V.K. Ramanan et al., Pathway analysis of genomic data: concepts, methods, and prospects for future development. Trends Genet. 28, 323–332 (2012)CrossRef V.K. Ramanan et al., Pathway analysis of genomic data: concepts, methods, and prospects for future development. Trends Genet. 28, 323–332 (2012)CrossRef
16.
Zurück zum Zitat K.A. Frazer et al., A second generation human haplotype map of over 3.1 million SNPs. Nature 449, 851–861 (2007)CrossRef K.A. Frazer et al., A second generation human haplotype map of over 3.1 million SNPs. Nature 449, 851–861 (2007)CrossRef
17.
Zurück zum Zitat J. Chen et al., Multifaceted genomic risk for brain function in schizophrenia. Neuroimage 61, 866–875 (2012)CrossRef J. Chen et al., Multifaceted genomic risk for brain function in schizophrenia. Neuroimage 61, 866–875 (2012)CrossRef
18.
Zurück zum Zitat D.P. Hibar et al., Voxelwise gene-wide association study (vGeneWAS): multivariate gene-based association testing in 731 elderly subjects. Neuroimage 56, 1875–1891 (2011)CrossRef D.P. Hibar et al., Voxelwise gene-wide association study (vGeneWAS): multivariate gene-based association testing in 731 elderly subjects. Neuroimage 56, 1875–1891 (2011)CrossRef
19.
Zurück zum Zitat T. Ge et al., Increasing power for voxel-wise genome-wide association studies: the random field theory, least square kernel machines and fast permutation procedures. Neuroimage 63, 858–873 (2012)CrossRef T. Ge et al., Increasing power for voxel-wise genome-wide association studies: the random field theory, least square kernel machines and fast permutation procedures. Neuroimage 63, 858–873 (2012)CrossRef
20.
Zurück zum Zitat O. Kohannim et al., Discovery and replication of gene influences on brain structure using LASSO regression. Front. Neurosci. 6, 115 (2012)CrossRef O. Kohannim et al., Discovery and replication of gene influences on brain structure using LASSO regression. Front. Neurosci. 6, 115 (2012)CrossRef
21.
Zurück zum Zitat L. Shen et al., Identifying neuroimaging and proteomic biomarkers for MCI and AD via the elastic net, in Multimodal Brain Image Analysis (Springer, 2011), pp. 27–34 L. Shen et al., Identifying neuroimaging and proteomic biomarkers for MCI and AD via the elastic net, in Multimodal Brain Image Analysis (Springer, 2011), pp. 27–34
22.
Zurück zum Zitat H. Wang et al., Identifying disease sensitive and quantitative trait-relevant biomarkers from multidimensional heterogeneous imaging genetics data via sparse multimodal multitask learning. Bioinformatics 28, i127–i136 (2012)CrossRef H. Wang et al., Identifying disease sensitive and quantitative trait-relevant biomarkers from multidimensional heterogeneous imaging genetics data via sparse multimodal multitask learning. Bioinformatics 28, i127–i136 (2012)CrossRef
23.
Zurück zum Zitat M. Silver et al., Pathways-driven sparse regression identifies pathways and genes associated with high-density lipoprotein cholesterol in two Asian cohorts. PLoS Genet. 9, e1003939 (2013)CrossRef M. Silver et al., Pathways-driven sparse regression identifies pathways and genes associated with high-density lipoprotein cholesterol in two Asian cohorts. PLoS Genet. 9, e1003939 (2013)CrossRef
24.
Zurück zum Zitat J. Liu et al., Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA. Hum. Brain Mapp. 30, 241–255 (2009)CrossRef J. Liu et al., Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA. Hum. Brain Mapp. 30, 241–255 (2009)CrossRef
25.
Zurück zum Zitat S.A. Meda et al., A large scale multivariate parallel ICA method reveals novel imaging–genetic relationships for Alzheimer’s disease in the ADNI cohort. Neuroimage 60, 1608–1621 (2012)CrossRef S.A. Meda et al., A large scale multivariate parallel ICA method reveals novel imaging–genetic relationships for Alzheimer’s disease in the ADNI cohort. Neuroimage 60, 1608–1621 (2012)CrossRef
26.
Zurück zum Zitat J. Chen et al., Guided exploration of genomic risk for gray matter abnormalities in schizophrenia using parallel independent component analysis with reference. Neuroimage 83, 384–396 (2013)CrossRef J. Chen et al., Guided exploration of genomic risk for gray matter abnormalities in schizophrenia using parallel independent component analysis with reference. Neuroimage 83, 384–396 (2013)CrossRef
27.
Zurück zum Zitat V.M. Vergara et al., A three-way parallel ICA approach to analyze links among genetics, brain structure and brain function. Neuroimage (2014) V.M. Vergara et al., A three-way parallel ICA approach to analyze links among genetics, brain structure and brain function. Neuroimage (2014)
28.
Zurück zum Zitat E. Le Floch et al., Significant correlation between a set of genetic polymorphisms and a functional brain network revealed by feature selection and sparse Partial Least Squares. Neuroimage 63, 11–24 (2012)CrossRef E. Le Floch et al., Significant correlation between a set of genetic polymorphisms and a functional brain network revealed by feature selection and sparse Partial Least Squares. Neuroimage 63, 11–24 (2012)CrossRef
29.
Zurück zum Zitat D. Lin et al., Correspondence between fMRI and SNP data by group sparse canonical correlation analysis. Med. Image. Anal. (2013) D. Lin et al., Correspondence between fMRI and SNP data by group sparse canonical correlation analysis. Med. Image. Anal. (2013)
30.
Zurück zum Zitat M. Vounou et al., Discovering genetic associations with high-dimensional neuroimaging phenotypes: a sparse reduced-rank regression approach. Neuroimage 53, 59–1147 (2010)CrossRef M. Vounou et al., Discovering genetic associations with high-dimensional neuroimaging phenotypes: a sparse reduced-rank regression approach. Neuroimage 53, 59–1147 (2010)CrossRef
31.
Zurück zum Zitat M. Vounou et al., Sparse reduced-rank regression detects genetic associations with voxel-wise longitudinal phenotypes in Alzheimer’s disease. Neuroimage 60, 700–716 (2012)CrossRef M. Vounou et al., Sparse reduced-rank regression detects genetic associations with voxel-wise longitudinal phenotypes in Alzheimer’s disease. Neuroimage 60, 700–716 (2012)CrossRef
32.
Zurück zum Zitat M. Silver et al., Identification of gene pathways implicated in Alzheimer’s disease using longitudinal imaging phenotypes with sparse regression. Neuroimage 63, 94–1681 (2012)CrossRef M. Silver et al., Identification of gene pathways implicated in Alzheimer’s disease using longitudinal imaging phenotypes with sparse regression. Neuroimage 63, 94–1681 (2012)CrossRef
33.
Zurück zum Zitat D. Lin et al., in Proceedings of the 2013 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Biomedical Engineering Department, Tulane University, New Orleans, LA, 70118, USA (2013), pp. 9–16 D. Lin et al., in Proceedings of the 2013 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Biomedical Engineering Department, Tulane University, New Orleans, LA, 70118, USA (2013), pp. 9–16
34.
Zurück zum Zitat H. Wang et al., From phenotype to genotype: an association study of longitudinal phenotypic markers to Alzheimer’s disease relevant SNPs. Bioinformatics 28, i619–i625 (2012)CrossRef H. Wang et al., From phenotype to genotype: an association study of longitudinal phenotypic markers to Alzheimer’s disease relevant SNPs. Bioinformatics 28, i619–i625 (2012)CrossRef
Metadaten
Titel
Imaging Genetics: Information Fusion and Association Techniques Between Biomedical Images and Genetic Factors
verfasst von
Dongdong Lin
Vince D. Calhoun
Yu-Ping Wang
Copyright-Jahr
2017
DOI
https://doi.org/10.1007/978-3-319-44981-4_7

Premium Partner