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Journal of Materials Science
Erschienen in: Journal of Materials Science 16/2019

13.05.2019 | Materials for life sciences

In vitro preparation and characterization of amorphous calcium carbonate nanoparticles for applications in curcumin delivery

verfasst von: Chaohui Rao, Xia Guo, Min Li, Xiaoqing Sun, Xiaojie Lian, Huifang Wang, Xianghua Gao, Baolong Niu, Wenfeng Li

Erschienen in: Journal of Materials Science | Ausgabe 16/2019

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Abstract

The development of high drug loading and sustained release nanoparticles by simple and economical methods is significant for the treatment of diseases. Amorphous calcium carbonate (ACC) is an ideal drug delivery system because of its excellent pH responsiveness, biocompatibility and biodegradability. In this work, ACC nanoparticles were successfully precipitated in ethanol–calcium solutions using ammonium carbonate as the internal source of CO2, which exhibited a relatively narrow size distribution in range of 10–200 nm. The microscopic morphology, amorphous characters, porous structure and thermal behavior of resultants were investigated by electron microscopy, Fourier-transform infrared spectroscopy, Brunauer–Emmett–Teller and thermogravimetric analysis, respectively. In vitro drug release assay showed that ACC nanoparticles had high loading capacity of curcumin (Cur) and favorable drug release properties. Furthermore, ACC-Cur showed excellent abilities to scavenge free radicals, protect Cur stability and damage A549 cells, providing a broadened space for the applications of this material in the fields of biomedical or food.
Vorheriger Artikel Porous 3-D thermoplastic polyurethane (TPU) scaffold modified with hydroxyapatite (HA) nanoparticles using an ultrasonic method
Nächster Artikel Microstructure and properties of underwater friction stir-welded 7003-T4/6060-T4 aluminum alloys

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Metadaten
Titel
In vitro preparation and characterization of amorphous calcium carbonate nanoparticles for applications in curcumin delivery
verfasst von
Chaohui Rao
Xia Guo
Min Li
Xiaoqing Sun
Xiaojie Lian
Huifang Wang
Xianghua Gao
Baolong Niu
Wenfeng Li
Publikationsdatum
13.05.2019
Verlag
Springer US
Erschienen in
Journal of Materials Science / Ausgabe 16/2019
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-019-03686-3

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