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Cognitive Neurodynamics
Erschienen in: Cognitive Neurodynamics 3/2019

01.02.2019 | Review Paper

Influence of pharmacological and epigenetic factors to suppress neurotrophic factors and enhance neural plasticity in stress and mood disorders

verfasst von: Shashikanta Tarai, Rupsha Mukherjee, Sharda Gupta, Albert A. Rizvanov, Andras Palotás, V. S. Chandrasekhar Pammi, Arindam Bit

Erschienen in: Cognitive Neurodynamics | Ausgabe 3/2019

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Abstract

Stress-induced major depression and mood disorders are characterized by behavioural abnormalities and psychiatric illness, leading to disability and immature mortality worldwide. Neurobiological mechanisms of stress and mood disorders are discussed considering recent findings, and challenges to enhance pharmacological effects of antidepressant, and mood stabilizers. Pharmacological enhancement of ketamine and scopolamine regulates depression at the molecular level, increasing synaptic plasticity in prefrontal regions. Blood-derived neurotrophic factors facilitate mood-deficit symptoms. Epigenetic factors maintain stress-resilience in hippocampal region. Regulation of neurotrophic factors blockades stress, and enhances neuronal survival though it paralyzes limbic regions. Molecular agents and neurotrophic factors also control behavioral and synaptic plasticity in addiction and stress disorders. Future research on neuronal dynamics and cellular actions can be directed to obtain the etiology of synaptic dysregulation in mood disorder and stress. For the first time, the current review contributes to the literature of synaptic plasticity representing the role of epigenetic mechanisms and glucocorticoid receptors to predict depression and anxiety in clinical conditions.
Nächster Artikel Neurobiological basis of feeling of knowing in episodic memory

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Metadaten
Titel
Influence of pharmacological and epigenetic factors to suppress neurotrophic factors and enhance neural plasticity in stress and mood disorders
verfasst von
Shashikanta Tarai
Rupsha Mukherjee
Sharda Gupta
Albert A. Rizvanov
Andras Palotás
V. S. Chandrasekhar Pammi
Arindam Bit
Publikationsdatum
01.02.2019
Verlag
Springer Netherlands
Erschienen in
Cognitive Neurodynamics / Ausgabe 3/2019
Print ISSN: 1871-4080
Elektronische ISSN: 1871-4099
DOI
https://doi.org/10.1007/s11571-019-09522-3

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