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2019 | OriginalPaper | Buchkapitel

Joint Shape Representation and Classification for Detecting PDAC

verfasst von : Fengze Liu, Lingxi Xie, Yingda Xia, Elliot Fishman, Alan Yuille

Erschienen in: Machine Learning in Medical Imaging

Verlag: Springer International Publishing

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Abstract

We aim to detect pancreatic ductal adenocarcinoma (PDAC) in abdominal CT scans, which sheds light on early diagnosis of pancreatic cancer. This is a 3D volume classification task with little training data. We propose a two-stage framework, which first segments the pancreas into a binary mask, then compresses the mask into a shape vector and performs abnormality classification. Shape representation and classification are performed in a joint manner, both to exploit the knowledge that PDAC often changes the shape of the pancreas and to prevent over-fitting. Experiments are performed on 300 normal scans and 136 PDAC cases. We achieve a specificity of \(90.2\%\) (false alarm occurs on less than 1/10 normal cases) at a sensitivity of \(80.2\%\) (less than 1/5 PDAC cases are not detected), which show promise for clinical applications.

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Fußnoten
1
Throughout this paper, an abnormal pancreas is defined as one suffering from PDAC.
 
2
To make our approach generalized, we do not assume the tumors are annotated in the training set, and so we do not perform tumor segmentation.
 
3
The early diagnosis of PDAC is difficult and can be uncertain from CT scans. In our case, the radiologists proved these PDAC cases with biopsy checks. They can easily miss some of these cases if they were not told their abnormality beforehand.
 
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Metadaten
Titel
Joint Shape Representation and Classification for Detecting PDAC
verfasst von
Fengze Liu
Lingxi Xie
Yingda Xia
Elliot Fishman
Alan Yuille
Copyright-Jahr
2019
DOI
https://doi.org/10.1007/978-3-030-32692-0_25

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