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14.10.2020 | Original Research

Fabrication of polysaccharides-based hydrogel films for transdermal sustained delivery of Ibuprofen

verfasst von: Xiao-Hui Wang, Ting Su, Jin Zhao, Zhi Wu, Dong Wang, Wen-Na Zhang, Qing-Xi Wu, Yan Chen

Erschienen in: Cellulose | Ausgabe 17/2020

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Abstract

Water-soluble polysaccharides of cellulose sulfate (NaCS) and chitosan hydrochloride (CHC) were chosen as the brick materials, while sodium tripolyphosphate (STPP) as a special “cement”, the NaCS/CHC/STPP hydrogel films loaded with Ibuprofen were fabricated via self-assembly method. The prepared hydrogel films were characterized via SEM, FTIR, TGA and XRD. It manifested that the hydrogel films formed a dense three-dimensional network with a regular shape, and NaCS, CHC and STPP were involved in the formation of polyelectrolyte complex via electrostatic interaction. The Ibuprofen-loaded hydrogel films possessed respective loading and encapsulation efficiency of 43.15 ± 4.88% and 60.65 ± 4.68%. It verified that the hydrogel films had favourable sustained release profile during 1440 min test, in which Ibuprofen could penetrate through the skin of mouse in a transdermal drug delivery (TDD) model. The cytotoxicity assays indicated that the hydrogel films had non-toxicity and good biocompatibility. All these results shed light on the hydrogel films prepared could be used to design potential TDD vehicles.

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Vorheriger Artikel Biosorption of copper using nopal fibres: moolooite formation and magnesium role in the reactive crystallization mechanism

Nächster Artikel Hydrophilic patterning of octadecyltrichlorosilane (OTS)-coated paper via atmospheric-pressure dielectric-barrier-discharge jet (DBDjet)

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Titel: Fabrication of polysaccharides-based hydrogel films for transdermal sustained delivery of Ibuprofen
verfasst von: Xiao-Hui Wang
Ting Su
Jin Zhao
Zhi Wu
Dong Wang
Wen-Na Zhang
Qing-Xi Wu
Yan Chen
Publikationsdatum: 14.10.2020
Verlag: Springer Netherlands
Erschienen in: Cellulose / Ausgabe 17/2020
Print ISSN: 0969-0239
Elektronische ISSN: 1572-882X
DOI: https://doi.org/10.1007/s10570-020-03503-0

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