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03.11.2020 | Materials for life sciences

Designed poly(ethylene glycol) conjugate-erbium-doped magnetic nanoparticle hybrid carrier: enhanced activity of anticancer drug

verfasst von: Kiruthiga Kaliyamoorthi, Archana Sumohan Pillai, Aleyamma Alexander, Sivaraj Ramasamy, Anitha Arivarasu, Israel V. M. V. Enoch

Erschienen in: Journal of Materials Science | Ausgabe 5/2021

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Abstract

Magnetic drug carriers are aimed at transporting the loaded drugs to the target site with the application of an external field. To realize this, a clever design of magnetic nanoparticles and their surface modification have to be achieved. Herein, we report the synthesis of ErFeO₃ nanoparticles and their magnetic characteristics. In addition, we report a β-cyclodextrin-polyethylene glycol-folate conjugate and utilize it for coating the magnetic nanoparticles. The crystallinity and grain size of the nanoparticles are characterized using X-ray diffraction. The elemental composition of the nanoparticles and their orbital states are determined using XPS spectroscopy. The polymer-coated nanoparticles are soft ferromagnetic. The anticancer drug, camptothecin, is loaded on the polymer-coated nanoparticles with a loading percentage of about 88%. The efficacy of camptothecin gets enhanced when loaded on the magnetic nanocarrier and released in a sustained manner. Compared to the free form, the drug loaded on the nanocarrier shows an enhanced anticancer activity.

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Vorheriger Artikel A strategy to prepare activated carbon fiber membranes for flexible solid-state supercapacitor applications

Nächster Artikel PVA-BA/PEG hydrogel with bilayer structure for biomimetic articular cartilage and investigation of its biotribological and mechanical properties

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Titel: Designed poly(ethylene glycol) conjugate-erbium-doped magnetic nanoparticle hybrid carrier: enhanced activity of anticancer drug
verfasst von: Kiruthiga Kaliyamoorthi
Archana Sumohan Pillai
Aleyamma Alexander
Sivaraj Ramasamy
Anitha Arivarasu
Israel V. M. V. Enoch
Publikationsdatum: 03.11.2020
Verlag: Springer US
Erschienen in: Journal of Materials Science / Ausgabe 5/2021
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI: https://doi.org/10.1007/s10853-020-05466-w

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