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Journal of Polymer Research
Erschienen in: Journal of Polymer Research 7/2018

01.07.2018 | ORIGINAL PAPER

Construction and evaluation of the hydroxypropyl methyl cellulose-sodium alginate composite hydrogel system for sustained drug release

verfasst von: Yan Hu, Shangwen Zhang, Dandan Han, Zongxian Ding, Suying Zeng, Xincai Xiao

Erschienen in: Journal of Polymer Research | Ausgabe 7/2018

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Abstract

We prepared a hydroxypropyl methyl cellulose-sodium alginate (HPMC-SA) composite hydrogel with a membrane covering the semi-interpenetrating network based on a semi-synthetic polymer hydroxypropyl methyl cellulose (HPMC) and a natural polymer sodium alginate (SA) by Ca2+ crosslinking and polyelectrolyte complexation with chitosan (CS) covering the hydrogel surface. The physiochemical properties of HPMC-SA hydrogels were evaluated by scanning electron microscopy, infrared spectrum, X-ray diffraction, and thermogravimetric analysis. The swelling ratio of the HPMC-SA composite hydrogel in simulated gastrointestinal fluid was measured. The drug release behavior of the HPMC-SA composite hydrogel for macro-molecular and small-molecule drugs was evaluated by using bovine serum albumin, metformin hydrochloride, and indomethacin as model drugs. The results showed that the HPMC-SA hydrogel had good water absorption and degradability, an increased swelling ratio of 55, and a prolonged time for maximum swelling degree of 50 h. Moreover, the hydrogel exhibited higher drug-loading capacity and improvements in the sustained release of bio-macromolecules, demonstrating its potential as a drug carrier for biomedical applications.
Vorheriger Artikel Synthesis and characterization of conjugated porous polyazomethines with excellent electrochemical energy storage performance
Nächster Artikel Melting performance of single screw extruders with a grooved melting zone

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Metadaten
Titel
Construction and evaluation of the hydroxypropyl methyl cellulose-sodium alginate composite hydrogel system for sustained drug release
verfasst von
Yan Hu
Shangwen Zhang
Dandan Han
Zongxian Ding
Suying Zeng
Xincai Xiao
Publikationsdatum
01.07.2018
Verlag
Springer Netherlands
Erschienen in
Journal of Polymer Research / Ausgabe 7/2018
Print ISSN: 1022-9760
Elektronische ISSN: 1572-8935
DOI
https://doi.org/10.1007/s10965-018-1546-y

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