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Medical & Biological Engineering & Computing

Erschienen in:

01.03.2006 | ORIGINAL ARTICLE

Control oriented model of insulin and glucose dynamics in type 1 diabetics

verfasst von: Pier Giorgio Fabietti, Valentina Canonico, Marco Orsini Federici, Massimo Massi Benedetti, Eugenio Sarti

Erschienen in: Medical & Biological Engineering & Computing | Ausgabe 1-2/2006

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Abstract

The aim of the study was to realize a mathematical model of insulin–glucose relationship in type I diabetes and test its effectiveness for the design of control algorithms in external artificial pancreas. A new mathematical model, divided into glucose and insulin sub-models, was developed from the so-called “minimal model”. The key feature is the representation of insulin sensitivity so as to permit the personalisation of the parameters. Real-time applications are based on an insulin standardised model. Clinical data were used to estimate model parameters. Root mean square error between simulated and real blood glucose profiles (G_rms) was used to evaluate system efficacy. Results from parameter estimation and insulin standardisation showed a good capability of the model to identify individual characteristics. Simulation results with a G_rms 1.30 mmol/l in the worst case testified the capacity of the model to accurately represent glucose–insulin relationship in type 1 diabetes allowing self tuning in real time.

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Titel: Control oriented model of insulin and glucose dynamics in type 1 diabetics
verfasst von: Pier Giorgio Fabietti
Valentina Canonico
Marco Orsini Federici
Massimo Massi Benedetti
Eugenio Sarti
Publikationsdatum: 01.03.2006
Verlag: Springer-Verlag
Erschienen in: Medical & Biological Engineering & Computing / Ausgabe 1-2/2006
Print ISSN: 0140-0118
Elektronische ISSN: 1741-0444
DOI: https://doi.org/10.1007/s11517-005-0012-2

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