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Erschienen in:
15.03.2022 | Original Article
Improving segmentation and classification of renal tumors in small sample 3D CT images using transfer learning with convolutional neural networks
Erschienen in: International Journal of Computer Assisted Radiology and Surgery | Ausgabe 7/2022
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Abstract
Purpose
Computed tomography (CT) images can display internal organs of patients and are particularly suitable for preoperative surgical diagnoses. The increasing demands for computer-aided systems in recent years have facilitated the development of many automated algorithms, especially deep convolutional neural networks, to segment organs and tumors or identify diseases from CT images. However, performances of some systems are highly affected by the amount of training data, while the sizes of medical image data sets, especially three-dimensional (3D) data sets, are usually small. This condition limits the application of deep learning.
Methods
In this study, given a practical clinical data set that has 3D CT images of 20 patients with renal carcinoma, we designed a pipeline employing transfer learning to alleviate the detrimental effect of the small sample size. A dual-channel fine segmentation network (FS-Net) was constructed to segment kidney and tumor regions, with 210 publicly available 3D images from a competition employed during the training phase. We also built discriminative classifiers to classify the benign and malignant tumors based on the segmented regions, where both handcrafted and deep features were tested.
Results
Our experimental results showed that the Dice values of segmented kidney and tumor regions were 0.9662 and 0.7685, respectively, which were better than those of state-of-the-art methods. The classification model using radiomics features can classify most of the tumors correctly.
Conclusions
The designed FS-Net was demonstrated to be more effective than simply fine-tuning on the practical small size data set given that the model can borrow knowledge from large auxiliary data without diluting the signal in primary data. For the small data set, radiomics features outperformed deep features in the classification of benign and malignant tumors. This work highlights the importance of architecture design in transfer learning, and the proposed pipeline is anticipated to provide a reference and inspiration for small data analysis.