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23.09.2022 | Original Article

Antibacterial activity and mechanism of newly developed Zr-30Ta and Zr-25Ta-5Ti alloys against implant-associated infection

verfasst von: Hai-Lin Yang, Akram Nasser Juaim, Ling Zou, Meng-Zhen Zhu, Xiao-Na Chen, Chen-Xu Ma, Xiong-Wen Zhou

Erschienen in: Rare Metals | Ausgabe 12/2022

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Abstract

Infection is a common problem after implantation, and the currently used Ti-based implants have insufficient antibacterial activities. The newly developed Zr-30Ta and Zr-25Ta-5Ti alloys exhibited good mechanical properties, low elastic moduli, and high corrosion resistance. In this work, their antibacterial activities and antibacterial mechanisms were investigated. The surface roughness, wettability, and charge of the alloys were evaluated using a profilometer, drop shape analyzer, and electrokinetic analyzer, respectively. The antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis was investigated using the inhibition zone assay, plate count assay, live/dead staining, and scanning electron microscopy (SEM). The reactive oxygen species release (ROS) was evaluated using the 2'7'-dichlorodihydrofluorescein diacetate (DCFH-DA) assay. The results demonstrated that Zr-30Ta and Zr-25Ta-5Ti alloys had favorable smooth, hydrophilic, negatively charged surfaces that decreased bacteria adhesion and prevented biofilm formation. Zr-30Ta and Zr-25Ta-5Ti alloys also exhibited a time-dependent decrease in the bacteria adhesion and viability. Zr-30Ta and Zr-25Ta-5Ti alloys were also found to induce direct membrane damage and increase ROS production, resulting in significantly better antibacterial activities than CP-Ti. Zr-30Ta and Zr-25Ta-5Ti alloys exhibited comparable antibacterial activities. This work suggests that the newly developed Zr-30Ta and Zr-25Ta-5Ti alloys have good antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis and are promising candidate materials for dental and orthopedic implants.

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Vorheriger Artikel Strategy to boost hydrolysis resistance and stabilize low infrared emissivity of ZrB2 via nanoscale LaF3 surface modification

Nächster Artikel High-temperature oxidation behavior of DZ125 Ni-based superalloy under tensile stress

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Titel: Antibacterial activity and mechanism of newly developed Zr-30Ta and Zr-25Ta-5Ti alloys against implant-associated infection
verfasst von: Hai-Lin Yang
Akram Nasser Juaim
Ling Zou
Meng-Zhen Zhu
Xiao-Na Chen
Chen-Xu Ma
Xiong-Wen Zhou
Publikationsdatum: 23.09.2022
Verlag: Nonferrous Metals Society of China
Erschienen in: Rare Metals / Ausgabe 12/2022
Print ISSN: 1001-0521
Elektronische ISSN: 1867-7185
DOI: https://doi.org/10.1007/s12598-022-02144-5

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