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Polymer Bulletin
Erschienen in: Polymer Bulletin 11/2016

18.03.2016 | Original Paper

Chitosan as a matrix for grafting methyl methacrylate: synthesis, characterization and evaluation of grafts for biomedical applications

verfasst von: Thiagarajan Hemalatha, Shachi Yadav, Gunasekaran Krithiga, Thotapalli P. Sastry

Erschienen in: Polymer Bulletin | Ausgabe 11/2016

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Abstract

This study intends to investigate the potentials of chitosan-g-PMMA [poly(methyl methacrylate)] graft copolymers in corneal tissue engineering. The polymerization reaction between chitosan and methyl methacrylate (MMA) was standardized by varying temperature, pH, initiator and monomer concentrations. 113 % grafting yield was obtained at 60 °C, pH 6, 2.1 × 10−3 mol/L of sodium metabisulfite and 1.48 × 10−3 mol/L of potassium persulphate and 1.99 × 10−4 mol/L of monomer concentration. Fourier transform infrared spectroscopy confirmed the grafting of PMMA onto chitosan. The grafts possessed better thermal stability compared to chitosan films. The rough-surfaced (as evidenced by scanning electron microscopy) grafts were able to degrade under in vitro conditions in presence of lysozyme. The grafts exhibited 88 % optical clarity and also supported the proliferation of human corneal epithelial cell line. The above results indicate the potentials of chitosan-g-PMMA and its possible use in corneal tissue engineering applications.
Vorheriger Artikel Effect of hard-segment content on rheological properties of glycidyl azide polyol-based energetic thermoplastic polyurethane elastomers
Nächster Artikel Preparation and characterization of biodegradable polyurethanes composites containing thermally treated attapulgite nanorods

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Metadaten
Titel
Chitosan as a matrix for grafting methyl methacrylate: synthesis, characterization and evaluation of grafts for biomedical applications
verfasst von
Thiagarajan Hemalatha
Shachi Yadav
Gunasekaran Krithiga
Thotapalli P. Sastry
Publikationsdatum
18.03.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Polymer Bulletin / Ausgabe 11/2016
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-016-1644-0

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