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Polymer Bulletin
Erschienen in: Polymer Bulletin 4/2019

11.08.2018 | Original Paper

Synthesis of polyvinyl alcohol/CuO nanocomposite hydrogel and its application as drug delivery agent

verfasst von: Yashar Ahmadian, Asghar Bakravi, Hamed Hashemi, Hassan Namazi

Erschienen in: Polymer Bulletin | Ausgabe 4/2019

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Abstract

In this research, polyvinyl alcohol (PVA) was chemically cross-linked using epichlorohydrin (ECH). The nanocomposite hydrogels containing copper oxide nanoparticles (CuONPs) were synthesized through immersion of polyvinyl alcohol hydrogel in copper sulfate solution with different concentrations. The produced Cu2+ ions from copper sulfate were bound to hydroxyl groups via metal complexation. With the addition of NaOH solution, Cu2+ ions were converted to copper oxide nanoparticles. The morphology, surface investigation and identification of nanoparticles in polymer matrix were characterized using Fourier transform infrared spectroscopy, X-ray diffraction and scanning electron microscopy. Swelling properties of the prepared nanocomposite hydrogels were investigated with various solutions such as the urea, urine, d-glucose, salt solutions (CaCl2 and NaCl) and buffers (pH 1.2 and 7.4). Copper oxide nanoparticles led to an increase in swelling capacity of nanocomposite hydrogels. Indeed, loading and release behaviors of ibuprofen on nanocomposite hydrogels were studied.

Graphical abstract

Vorheriger Artikel Supercapacitor based on in situ chemical synthesis of polypyrrole on rubber substrate: preparation and characterization
Nächster Artikel Development of antituberculosis melt-blown polypropylene filters coated with mangosteen extracts for medical face mask applications

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Metadaten
Titel
Synthesis of polyvinyl alcohol/CuO nanocomposite hydrogel and its application as drug delivery agent
verfasst von
Yashar Ahmadian
Asghar Bakravi
Hamed Hashemi
Hassan Namazi
Publikationsdatum
11.08.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Polymer Bulletin / Ausgabe 4/2019
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-018-2477-9

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