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Colloid and Polymer Science
Erschienen in: Colloid and Polymer Science 11/2012

01.07.2012 | Original Contribution

Synthesis and characterization of pH-responsive diblock copolymers with cadaverine side groups

verfasst von: Hong Wang, Yuejun Zhu, Xiaona Ren, Hong Zhang, Yebang Tan

Erschienen in: Colloid and Polymer Science | Ausgabe 11/2012

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Abstract

In this paper, we report the synthesis and characterization of a new pH-responsive diblock copolymer, methoxy poly(ethylene glycol)-b-poly[N1-(4-vinylbenzyl) pentane-1,5-diamine dihydrochloride] (mPEG-b-PVBPDA). The monomer with cadaverine side group (N1-(4-vinylbenzyl)pentane-1,5-diamine dihydrochloride, VBPDA) and the macroinitiator (mPEG-ACVA) were synthesized, respectively, and mPEG-b-PVBPDA was then obtained by free radical polymerization. The structure and molecular weight of mPEG-b-PVBPDA was confirmed by FTIR, 1H NMR, and GPC-MALLS measurements. At low pH, it is hydrophilic due to the protonation of the amine groups. With increasing pH, deprotonation occurs, and the hydrophobicity of PVBPDA block increases. This molecular feature leads to interesting aggregation behavior of mPEG-b-PVBPDA in aqueous solutions at different pH as revealed by DLS measurements, TEM observations, and fluorescence spectrometry. This polymer was further subjected to gene delivery evaluations, and promising DNA transfection capacity has been found.
Vorheriger Artikel Poly (N-isopropylacrylamide) microgel based assemblies for organic dye removal from water: microgel diameter effects
Nächster Artikel Controlling the properties of poly(amino ester urethane)–poly(ethylene glycol)–poly(amino ester urethane) triblock copolymer pH/temperature-sensitive hydrogel

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Metadaten
Titel
Synthesis and characterization of pH-responsive diblock copolymers with cadaverine side groups
verfasst von
Hong Wang
Yuejun Zhu
Xiaona Ren
Hong Zhang
Yebang Tan
Publikationsdatum
01.07.2012
Verlag
Springer-Verlag
Erschienen in
Colloid and Polymer Science / Ausgabe 11/2012
Print ISSN: 0303-402X
Elektronische ISSN: 1435-1536
DOI
https://doi.org/10.1007/s00396-012-2629-7

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