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Colloid and Polymer Science
Erschienen in: Colloid and Polymer Science 4/2015

01.04.2015 | Original Contribution

Gum ghatti-based biodegradable and conductive carriers for colon-specific drug delivery

verfasst von: Kashma Sharma, B. S. Kaith, Susheel Kalia, Vijay Kumar, H. C. Swart

Erschienen in: Colloid and Polymer Science | Ausgabe 4/2015

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Abstract

Conductive superabsorbent hydrogels based on gum ghatti (Gg)/methacrylic acid (MAA)/aniline (ANI) were synthesized by gamma radiations initiated by two-step aqueous polymerization. A cross-linking agent N,N′-methylene-bis-acrylamide was used in the polymerization process, and MAA was graft-copolymerized onto Gg by γ-rays. Influence of preparative conditions (absorbed dose, monomers, solvent, and cross-linker concentrations) on the swelling behavior of cross-linked polymer systems has been investigated. Synthesized superabsorbent hydrogels were characterized using thermogravimetric analysis and swelling studies. In biodegradation study of synthesized hydrogels by composting soil method, Gg-cl-poly(MAA-ipn-ANI) showed better degradation efficiency in comparison to Gg-cl-poly(MAA). Synthesized hydrogels were loaded with amoxicillin trihydrate as a model drug to investigate the release behavior of hydrogels at different pH media. Kinetics studies revealed that synthesized hydrogels exhibit a Fickian diffusion behavior at pH 2.4 and 7.2. However, at pH 9.2, a non-Fickian diffusion behavior was observed which make them very suitable for colon-specific drug delivery applications.
Vorheriger Artikel Impact of anionic and cationic polyacrylamide on the stability of aqueous alumina suspension—comparison of adsorption mechanism
Nächster Artikel Synthesis and characterization of cationic colloidal unimolecular polymer (CUP) particles

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Metadaten
Titel
Gum ghatti-based biodegradable and conductive carriers for colon-specific drug delivery
verfasst von
Kashma Sharma
B. S. Kaith
Susheel Kalia
Vijay Kumar
H. C. Swart
Publikationsdatum
01.04.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Colloid and Polymer Science / Ausgabe 4/2015
Print ISSN: 0303-402X
Elektronische ISSN: 1435-1536
DOI
https://doi.org/10.1007/s00396-015-3505-z

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