Skip to main content
Fachgebiete
Automobil + Motoren Bauwesen + Immobilien Business IT + Informatik Elektrotechnik + Elektronik Energie + Nachhaltigkeit Finance + Banking Management + Führung Marketing + Vertrieb Maschinenbau + Werkstoffe Versicherung + Risiko
DE
EN
Bücher
Zeitschriften
Themenseiten
Organisationspsychologie Projektmanagement Marketing Smart Manufacturing
Weitere Formate
Podcasts Webinare Technik Webinare Wirtschaft Kongresse Veranstaltungskalender Awards
Jetzt Einzelzugang starten
Zugang für Unternehmen
Referenzkunden
SLX-Digitalkonferenz: Zukunftswerkstatt 2024

Mehr Umsatz mit Top-Kontakten

Am 7. Mai erfahren Sie, wie Vertriebsteams Leadgenerierung, Leadnurturing und Leadstrategien effizient steuern können.
Erweiterte Suche
Anmelden
nach oben
Colloid and Polymer Science
Erschienen in: Colloid and Polymer Science 7/2015

01.07.2015 | Short Communication

Photo-induced synthesis glucose-responsive carriers for controlled release of insulin in vitro

verfasst von: Xiangxiang Du, Guohua Jiang, Lei Li, Yongkun Liu, Hua Chen, Qin Huang

Erschienen in: Colloid and Polymer Science | Ausgabe 7/2015

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

The glucose-responsive amphiphilic poly(PEGMA-co-AAPBA) copolymer micelles as drug carriers have been developed using 3-phenylpyruvic acid (3-PPA) as photoinitiator. Under the light irradiation, 3-PPA could be self-polymerized into the trimer structure to execute the emulsifier and initiator functions that confirmed by gas chromatography-mass spectrum (GC-MS) analysis. The structure and morphology of resultant poly(PEGMA-co-AAPBA) micelles were characterized by 1H NMR and TEM. Insulin, as the model drug of diabetes, was loaded into micelles during the photopolymerization process. The as-prepared polymeric micelles exhibited the excellent glucose sensitivity. The loaded insulin could be released from micelles triggered by regulation of temperature and glucose concentration in the environment. The new drug carriers provided a potential application for the therapy of diabetes based on glucose-sensitive controlled drug delivery systems.
Vorheriger Artikel Research on redox-responsive mesoporous silica nanoparticles functionalized with PEG via a disulfide bond linker as drug carrier materials

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Jetzt informieren
Literatur
1.
Yohann G, Bertin D, Gigmes D, Versace D-L, Lalevee J, Fouassier J-P (2010) Toward nitroxide-mediated photopolymerization. Macromolecules 43:2204–2212CrossRef
2.
Andrzejewska E (2001) Photopolymerization kinetics of multifunctional monomers. Prog Polym Sci 26:605–665CrossRef
3.
Jin L, Agag T, Yagci Y, Ishida H (2011) Methacryloyl-functional benzoxazine: photopolymerization and thermally activated polymerization. Macromolecules 44:767–772CrossRef
4.
Deeb C, Ecoffet C, Bachelot R, Plain J, Bouhelier A, Soppera O (2011) Plasmon-based free-radical photopolymerization: effect of diffusion on nanolithography processes. J Am Chem Soc 133:10535–10542CrossRef
5.
Gong T, Adzima BJ, Baker NH, Bowman CN (2013) Photopolymerization: photopolymerization reactions using the photoinitiated copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. Adv Mater 25:2024–2024
6.
Aimetti AA, Machen AJ, Anseth KS (2009) Poly(ethylene glycol) hydrogels formed by thiol-ene photopolymerization for enzyme-responsive protein delivery. Biomaterials 30:6048–6054CrossRef
7.
Guo R, Gao Y, Wu M, Wang H (2013) Aliphatic ketones and aldehydes as water-soluble photoinitiators for the photopolymerization of methacrylic acid. Polymer 54:4940–4947CrossRef
8.
Temel G, Karaca N, Arsu N (2010) Synthesis of main chain polymeric benzophenone photoinitiator via thiolene click chemistry and its use in free radical polymerization. J Polym Sci A Polym Chem 48:5306–5312CrossRef
9.
Carbone ND, Ene M, Lancaster JR, Koberstein JT (2013) Kinetics and mechanisms of radical-based branching/cross-linking reactions in preformed polymers induced by benzophenone and bis-benzophenone photoinitiators. Macromolecules 46:5434–5444CrossRef
10.
Cheng L, Shi W (2011) Synthesis and photoinitiating behavior of benzophenone-based polymeric photoinitiators used for UV curing coatings. Prog Org Coat 71:355–361CrossRef
11.
Chung Y-C, Kim HY, Choi JW, Chun BC (2014) Preparation of urethane-acrylates by the photopolymerization of acrylate monomers using a benzophenone initiator grafted onto a polyurethane copolymer. Macromol Res 22:1115–1124CrossRef
12.
Shi J, Chen P, Wang K, Lu J, Nie J (2014) A novel high efficiency benzophenone based polymeric photoinitiator from ring-opening polymerization of benzoxazine. Polym Sci Ser B 56:632–638CrossRef
13.
Ishihara K, Kyomoto M (2010) Photo-induced functionalization on biomaterials surfaces. J Photopolym Sci Technol 23:161–166CrossRef
14.
Zhang J, Liu L, Yang W (2010) Preparation of amino-functionalized polystyrene nanoparticles by photoinitiated emulsion. Acta Polym Sin 6:1451–1457CrossRef
15.
Weber A, Schlögl S, Resch K (2013) Effect of formulation and processing conditions on light shielding efficiency of thermotropic systems with fixed domains based on UV curing acrylate resins. J Appl Polym Sci 130:3299–3310CrossRef
16.
Griffith EC, Rapf RJ, Shoemaker RK, Carpenter BK, Vaida V (2014) Photoinitiated synthesis of self-assembled vesicles. J Am Chem Soc 136:3784–3787CrossRef
17.
Jiang G, Du X, Wei Z, Jiang T, Zhou H, Qiu Z (2014) Photoinitiated synthesis of multi-sensitive micelles for drug release. Eur Polym J 60:33–37CrossRef
18.
Jiang G, Jiang T, Chen H, Li L, Liu Y, Zhou H, Feng Y, Zhou J (2015) Preparation of multi-responsive micelles for controlled release of insulin. Colloid Polym Sci 293:209–215CrossRef
19.
Leermakers PA, Vesley GF (1963) The photochemistry of α-keto acids and α-keto esters. I. Photolysis of pyruvic acid and benzoylformic acid. J Am Chem Soc 85:3776–3779CrossRef
20.
Reed Harris AE, Ervens B, Shoemaker RK, Kroll JA, Rapf RJ, Griffith EC, Monod A, Vaida V (2014) Photochemical kinetics of pyruvic acid in aqueous solution. J Phys Chem A 118:8505–8516CrossRef
21.
Schouten S, Huguet C, Hopmans EC, Kienhuis MVM, Damsté JS (2007) Analytical methodology for TEX86 paleothermometry by high-performance liquid chromatography/atmospheric pressure chemical ionization-mass spectrometry. Anal Chem 79:2940–2944CrossRef
22.
Wang X, Jiang G, Wei Z, Li X, Tang B (2013) Preparation and drug release properties of CO2 stimulus-sensitive poly(N, N-dimethylaminoethyl methacrylate)-b-polystyrene nanoparticles. Eur Polym J 49:3165–3170CrossRef
23.
Wang X, Jiang G, Li X, Tang B, Wei Z, Mai C (2013) Synthesis of multi-responsive polymeric nanocarriers for controlled release of bioactive agents. Polym Chem 4:4574–4577CrossRef
24.
Jiang G, Sun X, Ma Y, Wang Y, Wang R, Wang X, Wang S (2013) Hyperbranched polyether surface functionalized with biomimetic zwitterionic polymers as potential drug release carriers. Soft Mater 11:288–293CrossRef
25.
Jiang G, Wang Y, Zhang R, Wang R, Wang X, Zhang M, Sun X, Bao S, Wang T, Wang S (2012) Preparation of redox-sensitive shell cross-linked nanoparticles for controlled release of bioactive agents. ACS Macro Lett 1:489–493CrossRef
26.
Liu G, Yang H, Ma R-J, Shi L-Q (2014) Phenylboronic acid based glucose-responsive polymeric materials for insulin delivery and glucose monitoring. Acta Polym Sin 10:1161–1173
27.
Watahiki R, Sato K, Suwa K, Niina S, Egawa Y, Seki T, Anzai J-I (2014) Multilayer films composed of phenylboronic acid-modified dendrimers sensitive to glucose under physiological conditions. J Mater Chem B 2:5809–5817CrossRef
28.
Wang L-L, Qiao J, Liu H-H, Hao J, Qi L, Zhou X-P, Li D, Nie Z-X, Mao L-Q (2014) Ratiometric fluorescent probe based on gold nanoclusters and alizarin red-boronic acid for monitoring glucose in brain microdialysate. Anal Chem 86:9758–9764CrossRef
29.
Giacomelli C, Schmidt V, Borsali R (2007) Nanocontainers formed by self-assembly of poly(ethylene oxide)-b-poly(glycerol monomethacrylate)-drug conjugates. Macromolecules 40:2148–2157CrossRef
30.
Ji X, Ma X, Bian L (2014) Spectral studies on the conformational transitions of bovine insulin during denaturant-induced unfolding. Chem Res Chin Univ 30:222–227CrossRef
31.
Kitagawa Y, Akinaga Y, Kawashima Y, Jung J, Ten-no S (2012) A QM/MM-MD study on protein electronic properties: circular dichroism spectra of oxytocin and insulin. Chem Phys 401:95–102CrossRef
Metadaten
Titel
Photo-induced synthesis glucose-responsive carriers for controlled release of insulin in vitro
verfasst von
Xiangxiang Du
Guohua Jiang
Lei Li
Yongkun Liu
Hua Chen
Qin Huang
Publikationsdatum
01.07.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Colloid and Polymer Science / Ausgabe 7/2015
Print ISSN: 0303-402X
Elektronische ISSN: 1435-1536
DOI
https://doi.org/10.1007/s00396-015-3625-5

Weitere Artikel der Ausgabe 7/2015

Colloid and Polymer Science 7/2015 Zur Ausgabe

Original Contribution

The study of deformation characteristics of polymer droplet under electric field

Original Contribution

Synthesis, surface properties, and antibacterial activity of polysiloxane quaternary ammonium salts containing epoxy group

Original Contribution

Two-cationic 2-methylbenzothiazole derivatives as green light absorbed sensitizers in initiation of free radical polymerization

Original Contribution

Novel synthesis of selective phase-shape orientation of AgInS2 nanoparticles at low temperature

Original Contribution

Understanding the effects of nucleating agent concentration on the polymorphic behavior of β-nucleated isotactic polypropylene with different melt structures

Original Contribution

Electrophoretic mobility and electric conductivity in suspensions of charge-regulating porous particles

Premium Partner

    Marktübersichten

    Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen. 

    Zur Marktübersicht
    Bildnachweise