Skip to main content
Fachgebiete
Automobil + Motoren Bauwesen + Immobilien Business IT + Informatik Elektrotechnik + Elektronik Energie + Nachhaltigkeit Finance + Banking Management + Führung Marketing + Vertrieb Maschinenbau + Werkstoffe Versicherung + Risiko
DE
EN
Bücher
Zeitschriften
Themenseiten
Organisationspsychologie Projektmanagement Marketing Smart Manufacturing
Weitere Formate
Podcasts Webinare Technik Webinare Wirtschaft Kongresse Veranstaltungskalender Awards
Jetzt Einzelzugang starten
Zugang für Unternehmen
Referenzkunden
SLX-Digitalkonferenz: Zukunftswerkstatt 2024

Mehr Umsatz mit Top-Kontakten

Am 7. Mai erfahren Sie, wie Vertriebsteams Leadgenerierung, Leadnurturing und Leadstrategien effizient steuern können.
Erweiterte Suche
Anmelden
nach oben
Journal of Materials Science
Erschienen in: Journal of Materials Science 20/2016

06.07.2016 | Original Paper

Molecularly imprinted polymers synthesized using reduction-cleavable hyperbranched polymers for doxorubicin hydrochloride with enhanced loading properties and controlled release

verfasst von: Fangfang Chen, Heng Chen, Xiao Duan, Jiqiong Jia, Jie Kong

Erschienen in: Journal of Materials Science | Ausgabe 20/2016

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

In this contribution, we reported a novel strategy to synthesize porous molecularly imprinted polymers (MIPs) of anticancer drug of doxorubicin hydrochloride (DOX) using reduction-cleavable hyperbranched polymers containing disulfide bonds (ds-HP-alkyne). The porous MIPs (MIP-DOX-HP) possess enhanced specific surface area and porosity by the incorporation of cleavable hyperbranched polymers from the copper(I)–catalyzed azide–alkyne click chemistry. In comparison to MIPs synthesized without using ds-HP-alkyne, MIP-DOX-HP exhibits more regular and open porous structures, which increase the loading and controlled release abilities of DOX anticancer drug. Under optimized pH condition, the total cumulative release amount of DOX at equilibrium is as high as 2134 and 1249 µg for MIP-DOX-HP and MIP-DOX, respectively. The effective and robust strategy for synthesizing MIPs using cleavable hyperbranched polymers is helpful for extending applications of MIPs in drug delivery and target-activated release systems.
Vorheriger Artikel Use of epoxypropoxy-propyl-trimethoxysilane in the fabrication of bioactive gelatin microspheres using an emulsification method
Nächster Artikel Characterization of the photoactivity of nanotube layers grown on Ti–35Nb and Ti–35Nb–4Sn alloys

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Jetzt informieren
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Suksaeree J, Pichayakorn W, Monton C et al (2014) Polymers for transdermal drug delivery systems. Ind Eng Chem Res 53:507–513CrossRef
2.
del Valle EMM, Galan MA, Carbonell RG (2009) Drug delivery technologies: the way forward in the new decade. Ind Eng Chem Res 48:2475–2486CrossRef
3.
Kompella UB, Amrite AC, Ravi RP, Durazo SA (2013) Nanomedicines for back of the eye drug delivery, gene delivery, and imaging. Prog Retin Eye Res 36:172–198CrossRef
4.
Ma X, Zhou Z, Jin E, Sun Q, Zhang B, Tang J, Shen Y (2013) Facile synthesis of polyester dendrimers as drug delivery carriers. Macromolecules 46:37–42CrossRef
5.
Guse C, Koennings S, Kreye F, Siepmann F, Goepferich A, Siepmann J (2006) Drug release from lipid-based implants: elucidation of the underlying mass transport mechanisms. Int J Pharm 314:137–144CrossRef
6.
Ha W, Yu J, Song XY, Zhang ZJ, Liu YQ, Shi YP (2013) Prodrugs forming multifunctional supramolecular hydrogels for dual cancer drug delivery. J Mater Chem B 1:5532–5538CrossRef
7.
Lu CH, Zhou WH, Han B, Yang HH, Chen X, Wang XR (2007) Surface-imprinted core-shell nanoparticles for sorbent assays. Anal Chem 79:5457–5461CrossRef
8.
Schirhagl R (2014) Bioapplications for molecularly imprinted polymers. Anal Chem 86:250–261CrossRef
9.
Svenson J, Nicholls IA (2001) On the thermal and chemical stability of molecularly imprinted polymers. Anal Chim Acta 435:19–24CrossRef
10.
Zhu T, Xu D, Wu Y, Li J, Zhou M, Tian T, Jiang Y, Li F, Li G (2013) Surface molecularly imprinted electrospun affinity membranes with multimodal pore structures for efficient separation of proteins. J Mater Chem B 1:6449–6458CrossRef
11.
Tong K, Xiao S, Li S, Wang J (2008) Molecular recognition and catalysis by molecularly imprinted polymer catalysts: thermodynamic and kinetic surveys on the specific behaviors. J Inorg Organomet Polym Mater 18:426–433CrossRef
12.
Liu S, Yan H, Wang M, Wang L (2013) Water-compatible molecularly imprinted microspheres in pipette tip solid-phase extraction for simultaneous determination of five fluoroquinolones in eggs. J Agric Food Chem 61:11974–11980CrossRef
13.
Ansell RJ, Kuah JKL, Wang D, Jackson CE, Bartle KD, Clifford AA (2012) Imprinted polymers for chiral resolution of (±)-ephedrine, 4: packed column supercritical fluid chromatography using molecularly imprinted chiral stationary phases. J Chromatogr A 1264:117–123CrossRef
14.
Lulinski P (2010) Molecular imprinted polymers in pharmaceutical sciences. Polimery 55:799–805
15.
Puoci F, Iemma F, Cirillo G, Picci N, Matricardi P, Alhaique F (2007) Molecularly imprinted polymers for 5-fluorouracil release in biological fluids. Molecules 12:805–814CrossRef
16.
Dramou P, Zuo P, He H, Lien Ai PH, Zou W, Xiao D, Chuong PH, Ndorbor T (2013) Anticancer loading and controlled release of novel water-compatible magnetic nanomaterials as drug delivery agents, coupled to a computational modeling approach. J Mater Chem B 1:4099–4109CrossRef
17.
Parisi OI, Morelli C, Puoci F, Saturnino C, Caruso A, Sisci D, Trombino GE, Picci N, Sinicropi MS (2014) Magnetic molecularly imprinted polymers (MMIPs) for carbazole derivative release in targeted cancer therapy. J Mater Chem B 2:6619–6625CrossRef
18.
Chen L, Xu S, Li J (2011) Recent advances in molecular imprinting technology: current status, challenges and highlighted applications. Chem Soc Rev 40:2922–2942CrossRef
19.
He Y, Huang Y, Jin Y, Liu X, Liu G, Zhao R (2014) Well-defined nanostructured surface-imprinted polymers for highly selective magnetic separation of fluoroquinolones in human urine. ACS Appl Mat Interfaces 6:9634–9642CrossRef
20.
Zhu XY, Zhou YF, Yan DY (2011) Influence of branching architecture on polymer properties. J Polym Sci Part B 49:1277–1286CrossRef
21.
Wu WB, Qin JG, Li Z (2013) New design strategies for second-order nonlinear optical polymers and dendrimers. Polymer 54:4351–4382CrossRef
22.
Chen H, Kong J (2016) Hyperbranched polymers from A2+B3 Strategy: recent advances in description and control of fine topology. Polym Chem 7:3643–3663CrossRef
23.
Kong J, Wang MJ, Zou JH, An LN (2015) Soluble and meltable hyperbranched polyborosilazanes towards high-temperature stable SiBCN ceramics. ACS Appl Mater Interfaces 7:6733–6744CrossRef
24.
Chen H, Kong J, Tian W, Fan XD (2012) Intramolecular cyclization in A2+B3 polymers prepared by step-wise polymerization resulting in a highly branched topology: quantitative determination of cycles by combined NMR and SEC analytics. Macromolecules 45:6185–6195CrossRef
25.
Smeets NMB (2013) Amphiphilic hyperbranched polymers from the copolymerization of a vinyl and divinyl monomer: the potential of catalytic chain transfer polymerization. Eur Polym J 49:2528–2544CrossRef
26.
Schuell C, Frey H (2013) Grafting of hyperbranched polymers: from unusual complex polymer topologies to multivalent surface functionalization. Polymer 54:5443–5455CrossRef
27.
Wurm F, Frey H (2012) Hyperbranched polymers: synthetic methodology, properties, and complex polymer architectures. Polym Sci 6:177–198
28.
Yao B, Mei J, Li J, Wang J, Wu H, Sun JZ, Qin A, Tang BZ (2014) Catalyst-free thiol-yne click polymerization: a powerful and facile tool for preparation of functional poly(vinylene sulfide)s. Macromolecules 47:1325–1333CrossRef
29.
Zhao F, Yin H, Zhang Z, Li J (2013) Folic acid modified cationic gamma-cyclodextrin -oligoethylenimine star polymer with bioreducible disulfide linker for efficient targeted gene delivery. Biomacromolecules 14:476–484CrossRef
30.
Li L, Wang X, Yang J, Ye X, Wu C (2014) Degradation kinetics of model hyperbranched chains with uniform subchains and controlled locations of cleavable disulfide linkages. Macromolecules 47:650–658CrossRef
31.
Tang LY, Wang YC, Li Y, Du JZ, Wang J (2009) Shell-detachable micelles based on disulfide-linked block copolymer as potential carrier for intracellular drug delivery. Bioconj Chem 20:1095–1099CrossRef
32.
Wang F, Wang YC, Dou S, Xiong MH, Sun TM, Wang J (2011) Doxorubicin-tethered responsive gold nanoparticles facilitate intracellular drug delivery for overcoming multidrug resistance in cancer cells. ACS Nano 5:3679–3692CrossRef
33.
Prabaharan M, Grailer JJ, Pilla S, Steeber DA, Gong S (2009) Amphiphilic multi-arm-block copolymer conjugated with doxorubicin via pH-sensitive hydrazone bond for tumor-targeted drug delivery. Biomaterials 30:5757–5766CrossRef
34.
Wan D, Ohta S, Kakuchi T, Satoh T (2011) A hydrophilic unimolecular nanocapsule with cyclodextrin moieties in the core: chemically triggered on-demand release and pH-response. Soft Matter 7:6422–6425CrossRef
35.
Jiang L, Gao ZM, Ye L, Zhang AY, Feng ZG (2013) A tumor-targeting nano doxorubicin delivery system built from amphiphilic polyrotaxane-based block copolymers. Polymer 54:5188–5198CrossRef
36.
Xie XY, Pan XY, Han SL, Wang SC (2015) Development and characterization of magnetic molecularly imprinted polymers for the selective enrichment of endocrine disrupting chemicals in water and milk samples. Anal Bioanal Chem 407:1735–1744CrossRef
37.
Shen X, Ye L (2011) Interfacial molecular imprinting in nanoparticle-stabilized emulsions. Macromolecules 44:5631–5637CrossRef
38.
Molina EF, Parreira RLT, De Faria EH, de Carvalho HWP, Caramori GF, Coimbra DF, Nassar EJ, Ciuffi KJ (2014) Ureasil-poly(ethylene oxide) hybrid matrix for selective adsorption and separation of dyes from water. Langmuir 30:3857–3868CrossRef
39.
Zhou Y, Huang W, Liu J, Zhu X, Yan D (2010) Self-ssembly of hyperbranched polymers and its biomedical applications. Adv Mater 22:4567–4590CrossRef
40.
Chen H, Kong J (2014) Terminal index: a new way for precise description of topologic structure of highly branched polymers derived from A2+B3 stepwise polymerization. J Phys Chem B 118:3441–3450CrossRef
41.
Chen H, Zhang S, Kong J (2015) Topological analysis and intramolecular cyclic feature evaluation of highly branched polymers derived from Am+Bn step-growth polymerization. Polym Chem 6:909–916CrossRef
42.
Yang KG, Liu ZB, Mao M, Zhang XH, Zhao CS, Nishi N (2005) Molecularly imprinted polyethersulfone microspheres for the binding and recognition of bisphenol A. Anal Chim Acta 546:30–36CrossRef
43.
Zhao WF, Tang YS, Xi J, Kong J (2015) Covalent functionalization of chemically-converted graphene sheets with poly(ionic liquid)s and high adsorption capacity of anionic dyes. Appl Surf Sci 326:276–284CrossRef
44.
Meng LL, Zhang XF, Tang YS, Su KH, Kong J (2015) Hierarchically porous silicon-carbon-nitrogen hybrid materials towards highly efficient and selective adsorption of organic dyes. Sci Rep 5:7910CrossRef
45.
Yilmaz E, Mosbach K, Haupt K (1999) Influence of functional and cross-linking monomers and the amount of template on the performance of molecularly imprinted polymers in binding assays. Anal Commun 36:167–170CrossRef
Metadaten
Titel
Molecularly imprinted polymers synthesized using reduction-cleavable hyperbranched polymers for doxorubicin hydrochloride with enhanced loading properties and controlled release
verfasst von
Fangfang Chen
Heng Chen
Xiao Duan
Jiqiong Jia
Jie Kong
Publikationsdatum
06.07.2016
Verlag
Springer US
Erschienen in
Journal of Materials Science / Ausgabe 20/2016
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-016-0183-2

Weitere Artikel der Ausgabe 20/2016

Journal of Materials Science 20/2016 Zur Ausgabe

Original Paper

Tunable electronic structures and magnetism in arsenene nanosheets via transition metal doping

Original Paper

Asymmetric flow electrochemical capacitor with high energy densities based on birnessite-type manganese oxide nanosheets and activated carbon slurries

Original Paper

Template-sacrificed synthesis of polypyrrole nanofibers for lithium battery

Original Paper

Effect of W on tempering behaviour of a 3 %Co modified P92 steel

Original Paper

Photosynthesis of poly(glycidyl methacrylate) microspheres: a component for making covalently cross-linked colloidosomes and organic/inorganic nanocomposites

Original Paper

Improvement of compressive strength of lime mortar with carboxymethyl cellulose

Premium Partner

    Marktübersichten

    Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen. 

    Zur Marktübersicht
    Bildnachweise