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Journal of Materials Science
Erschienen in: Journal of Materials Science 20/2016

05.07.2016 | Original Paper

Use of epoxypropoxy-propyl-trimethoxysilane in the fabrication of bioactive gelatin microspheres using an emulsification method

verfasst von: Maryam Farokhi, Nader Nezafati, Mojgan Heydari, Saeed Hesaraki

Erschienen in: Journal of Materials Science | Ausgabe 20/2016

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Abstract

Gelatin microspheres (GMs) using various concentrations of epoxypropoxy-propyl-trimethoxysilane (EPPTMS) as a crosslinking agent were prepared. Since the crosslinking agent content and manufacturing conditions are crucial factors in the characteristics of the microspheres, this study was carried out to evaluate the effect of processing variables on morphology, and in vitro behavior of GMs using acellular simulated body fluid (SBF). It was found that the best morphology was acquired in terms of both shape and uniformity for the GMs containing a certain concentration of EPPTMS (20wt%), whereas other concentrations yielded rambling spheres. The results revealed that the size of microspheres became smaller when both the oil-to-water ratio and agitation rate were increased. Moreover, the density of the crosslinking agent was also dependent on the above-mentioned factors in 20wt% EPPTMS. Different morphologies of hydroxyapatite deposits on the surface of GMs were observed after 14 days of soaking in SBF. These in vitro acellular studies were confirmed by SEM, FTIR, and XRD analyses. According to the results of UV–Vis spectroscopy, the GMs were released into the SBF solution in a time-dependent manner; however, the fastest rate of release occurred for the largest GM.
Vorheriger Artikel Study of the influence of saline solutions in carbon/epoxy composite by luminescence, Raman and UATR/FT-IR spectroscopy
Nächster Artikel Molecularly imprinted polymers synthesized using reduction-cleavable hyperbranched polymers for doxorubicin hydrochloride with enhanced loading properties and controlled release

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Metadaten
Titel
Use of epoxypropoxy-propyl-trimethoxysilane in the fabrication of bioactive gelatin microspheres using an emulsification method
verfasst von
Maryam Farokhi
Nader Nezafati
Mojgan Heydari
Saeed Hesaraki
Publikationsdatum
05.07.2016
Verlag
Springer US
Erschienen in
Journal of Materials Science / Ausgabe 20/2016
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-016-0182-3

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