Skip to main content
Fachgebiete
Automobil + Motoren Bauwesen + Immobilien Business IT + Informatik Elektrotechnik + Elektronik Energie + Nachhaltigkeit Finance + Banking Management + Führung Marketing + Vertrieb Maschinenbau + Werkstoffe Versicherung + Risiko
DE
EN
Themenseiten
Organisationspsychologie Projektmanagement Marketing Smart Manufacturing
Bücher
Zeitschriften
Weitere Formate
Podcasts Webinare Technik Webinare Wirtschaft Kongresse Veranstaltungskalender Awards
Jetzt Einzelzugang starten
Zugang für Unternehmen
Referenzkunden
MTZ-Fachkongress

Antriebe und Energiesysteme von morgen


Austausch von Automobil- und Energiewirtschaft

Am 14./15. Mai geht es in Chemnitz um die Mobilitätswende durch Elektro- und Wasserstofffahrzeuge.
Erweiterte Suche
Anmelden
nach oben
Journal of Materials Science
Erschienen in: Journal of Materials Science 7/2018

28.12.2017 | Biomaterials

Silver nanoparticles with low cytotoxicity: controlled synthesis and surface modification with histidine

verfasst von: Guansong Hu, Guorun Liang, Wen Zhang, Wenxiu Jin, Yan Zhang, Qingyuan Chen, Yuchun Cai, Wanzhong Zhang

Erschienen in: Journal of Materials Science | Ausgabe 7/2018

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Due to the controlled release of Ag+, silver nanoparticles (AgNPs) not only display excellent anticancer activity but also possess cytotoxicity on normal cells. Up to now, no efficient method has been found to eliminate the side effect. In this study, AgNPs with different morphologies were synthesized and some main factors, i.e., the seed amount, CTAB concentration and temperature were discussed. Histidine (His) was applied to modify three kinds of AgNPs (near nanospheres, short nanorods and long nanorods) prepared by the above controlled synthesis, and the bioactivity of the modified AgNPs on cancer and normal cells was investigated. The results showed that the morphology and particle size of AgNPs had strong dependency on the quantity of seeds and reaction temperature except for CTAB concentration. IR spectra showed that His molecules had linked to AgNPs by coordination between AgNPs and C–N group of the imidazolyl in His. The bioactivity experiments in vitro showed that the cytotoxicity of His-modified AgNPs on HL7702 cells was effectively reduced and the anti-tumor activity against MCF-7 cells was not influenced obviously. The results supported that the His-modified AgNPs possess less cytotoxicity and higher targeting anticancer activity and thus the silver nanomaterials modified by His displayed potential applications for cancer therapies. We also suggested that the possible mechanism on the reduction of the cytotoxicity was that His-modified AgNPs could target cancer cells to decrease the cytotoxicity but affect a little on the viability of normal cells.
Vorheriger Artikel Effect of the adhesion of Ag coatings on the effectiveness and durability of antibacterial properties
Nächster Artikel Anti-freezing asphalt concrete: ice-adhesion performance

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Jetzt informieren
Literatur
1.
2.
3.
De Matteis V, Rizzello L, Di Bello MP, Rinaldi R (2017) One-step synthesis, toxicity assessment and degradation in tumoral pH environment of SiO2@Ag core/shell nanoparticles. J Nanopart Res 19:196
4.
Elbaz NM, Ziko L, Siam R, Mamdouh W (2016) Core-shell silver/polymeric nanoparticles-based combinatorial therapy against breast cancer in-vitro. Sci Rep 6:30729
5.
Ganta S, Devalapally H, Shahiwala A, Amiji M (2008) A review of stimuli-responsive nanocarriers for drug and gene delivery. J Controll Release 126:187–204CrossRef
6.
7.
8.
Hu G, Jin W, Chen Q, Cai Y, Zhu Q, Zhang W (2016) Antibacterial activity of silver nanoparticles with different morphologies as well as their possible antibacterial mechanism. Appl Phys Mater Sci Process 122:874
9.
Guo DW, Zhu LY, Huang ZH, Zhou HX, Ge Y, Ma WJ, Wu J, Zhang XY, Zhou XF, Zhang Y, Zhao Y, Gu N (2013) Anti-leukemia activity of PVP-coated silver nanoparticles via generation of reactive oxygen species and release of silver ions. Biomaterials 34:7884–7894CrossRef
10.
Gurunathan S, Han JW, Dayem AA, Eppakayala V, Park JH, Cho SG, Lee KJ, Kim JH (2013) Green synthesis of anisotropic silver nanoparticles and its potential cytotoxicity in human breast cancer cells (MCF-7). J Ind Eng Chem 19:1600–1605CrossRef
11.
Zhang W, Hu G, Zhang W, Qiao X, Wu K, Chen Q, Cai Y (2014) Surfactant-directed synthesis of silver nanorods and characteristic spectral changes occurred by their morphology evolution. Phys E Low Dimens Syst Nanostruct 64:211–217CrossRef
12.
Chen SH, Carroll DL (2002) Synthesis and characterization of truncated triangular silver nanoplates. Nano Lett 2:1003–1007CrossRef
13.
Murphy CJ, Jana NR (2002) Controlling the aspect ratio of inorganic nanorods and nanowires. Adv Mater 14:80–82CrossRef
14.
Jana NR, Gearheart L, Murphy CJ (2001) Wet chemical synthesis of silver nanorods and nanowires of controllable aspect ratio. Chem Commun 7:617–618CrossRef
15.
Jana NR (2004) Shape effect in nanoparticle self-assembly. Angew Chem Int Ed 43:1536–1540CrossRef
16.
Lee GJ, Shin SI, Kim YC, Oh SG (2004) Preparation of silver nanorods through the control of temperature and pH of reaction medium. Mater Chem Phys 84:197–204CrossRef
17.
Zhang W, Zhang W, Qiao X, Qiu X, Chen Q, Cai Y (2014) Controllable preparation of silver nanostructures and the effects of acidity-basicity of the reaction system. Sci Adv Mater 6:304–311CrossRef
18.
Nangmenyi G, Li XA, Mehrabi S, Mintz E, Economy J (2011) Silver-modified iron oxide nanoparticle impregnated fiberglass for disinfection of bacteria and viruses in water. Mater Lett 65:1191–1193CrossRef
19.
Govindaraju K, Krishnamoorthy K, Alsagaby SA, Singaravelu G, Premanathan M (2015) Green synthesis of silver nanoparticles for selective toxicity towards cancer cells. IET Nanobiotechnol 9:325–330CrossRef
20.
Zhang XF, Liu ZG, Shen W, Gurunathan S (2016) Silver nanoparticles: synthesis, characterization, properties, applications, and therapeutic approaches. Int J Mol Sci 17:34CrossRef
21.
Zhong YA, Meng FH, Deng C, Zhong ZY (2014) Ligand-directed active tumor-targeting polymeric nanoparticles for cancer chemotherapy. Biomacromolecules 15:1955–1969CrossRef
22.
Awasthi KK, Awasthi A, Verma R, Kumar N, Roy P, Awasthi K, John PJ (2015) Cytotoxicity, genotoxicity and alteration of cellular antioxidant enzymes in silver nanoparticles exposed CHO cells. RSC Adv 5:34927–34935CrossRef
23.
Ivask A, Juganson K, Bondarenko O, Mortimer M, Aruoja V, Kasemets K, Blinova I, Heinlaan M, Slaveykova V, Kahru A (2014) Mechanisms of toxic action of Ag, ZnO and CuO nanoparticles to selected ecotoxicological test organisms and mammalian cells in vitro: A comparative review. Nanotoxicology 8:57–71CrossRef
24.
Eom HJ, Chatterjee N, Lee J, Choi J (2014) Integrated mRNA and micro RNA profiling reveals epigenetic mechanism of differential sensitivity of Jurkat T cells to AgNPs and Ag ions. Toxicol Lett 229:311–318CrossRef
25.
Liang JM, Zeng F, Zhang M, Pan ZZ, Chen YZ, Zeng YN, Xu Y, Xu Q, Huang YZ (2015) Green synthesis of hyaluronic acid-based silver nanoparticles and their enhanced delivery to CD44(+) cancer cells. RSC Adv 5:43733–43740CrossRef
26.
Li J, You J, Dai Y, Shi M, Han C, Xu K (2014) Gadolinium oxide nanoparticles and aptamer-functionalized silver nanoclusters-based multimodal molecular imaging nanoprobe for optical/magnetic resonance cancer cell imaging. Anal Chem 86:11306–11311CrossRef
27.
Zhang ZH, Liu CH, Bai JH, Wu CC, Xiao Y, Li YH, Zheng J, Yang RH, Tan WH (2015) Silver nanoparticle gated, mesoporous silica coated gold nanorods (AuNR@MS@AgNPs): low premature release and multifunctional cancer theranostic platform. ACS Appl Mater Interfaces 7:6211–6219CrossRef
28.
Shannahan JH, Podila R, Aldossari AA, Emerson H, Powell BA, Ke PC, Rao AM, Brown JM (2015) Formation of a protein corona on silver nanoparticles mediates cellular toxicity via scavenger receptors. Toxicol Sci 143:136–146CrossRef
29.
Jegatheeswaran S, Selvam S, Ramkumar VS, Sundrarajan M (2016) Facile green synthesis of silver doped fluor-hydroxyapatite/beta-cyclodextrin nanocomposite in the dual acting fluorine-containing ionic liquid medium for bone substitute applications. Appl Surf Sci 371:468–478CrossRef
30.
Kelestemur S, Altunbek M, Culha M (2017) Influence of EDC/NHS coupling chemistry on stability and cytotoxicity of ZnO nanoparticles modified with proteins. Appl Surf Sci 403:455–463CrossRef
31.
Zhang W, Qiao X, Chen Q, Cai Y, Chen H (2012) The influence of synthesis condition and aging process of silver nanocrystals on the formation of silver nanorods. Appl Surf Sci 258:5909–5913CrossRef
32.
Liu X, He TJ, Liu FC, Chen DM (2005) Preparation and spectroscopic studies of silver nanorod colloids. Chin J Chem Phys 18:81–86
33.
Jana NR, Gearheart L, Murphy CJ (2001) Wet chemical synthesis of high aspect ratio cylindrical gold nanorods. J Phys Chem B 105:4065–4067CrossRef
34.
El-Sayed MA (2001) Some interesting properties of metals confined in time and nanometer space of different shapes. Acc Chem Res 34:257–264CrossRef
35.
Tornblom M, Henriksson U (1997) Effect of solubilization of aliphatic hydrocarbons on size and shape of rodlike C16TABr micelles studied by 2H NMR relaxation. J Phys Chem B 101:6028–6035CrossRef
36.
Al-Thabaiti SA, Obaid AY, Hussain S, Khan Z (2015) Shape-directing role of cetyltrimethylammonium bromide on the morphology of extracellular synthesis of silver nanoparticles. Arab J Chem 8:538–544CrossRef
37.
Bergstrom LM (2016) Second CMC in surfactant micellar systems. Curr Opin Colloid Interface Sci 22:46–50CrossRef
38.
And SM, Benshaul A (2001) Molecular theory of the sphere-to-rod transition and the second CMC in aqueous micellar solutions. J Phys Chem B 105:630–640CrossRef
39.
Shi Y, Luo HQ, Li NB (2011) Determination of the critical premicelle concentration, first critical micelle concentration and second critical micelle concentration of surfactants by resonance Rayleigh scattering method without any probe. Spectroc Acta Pt A Mol Biomol Spectr 78:1403–1407CrossRef
40.
Sui ZM, Chen X, Wang LY, Xu LM, Zhuang WC, Chai YC, Yang CJ (2006) Capping effect of CTAB on positively charged Ag nanoparticles. Phys E Low Dimens Syst Nanostruct 33:308–314CrossRef
41.
Li H, Tripp CP (2004) Use of infrared bands of the surfactant headgroup to identify mixed surfactant structures adsorbed on Titania. J Phys Chem B 108:18318–18326CrossRef
42.
Kumar S, Rai AK, Rai SB, Rai DK (2010) Infrared and Raman spectra of Histidine : an ab initio DFT calculations of Histidine molecule and its different protonated forms. Indian J Phys 84:563–573CrossRef
43.
Hasegawa K, T-a O, Noguchi T (2000) Vibrational spectra and ab initio DFT calculations of 4-methylimidazole and its different protonation forms: Infrared and Raman markers of the protonation state of a histidine side chain. J Phys Chem B 104:4253–4265CrossRef
44.
Noguchi T, Inoue Y, Tang X-S (1999) Structure of a histidine ligand in the photosynthetic oxygen-evolving complex as studied by light-induced Fourier transform infrared difference spectroscopy. Biochemistry 38:10187–10195CrossRef
45.
Chen Z, Zhang X, Cao H, Huang Y (2013) Chitosan-capped silver nanoparticles as a highly selective colorimetric probe for visual detection of aromatic ortho-trihydroxy phenols. Analyst 138:2343–2349CrossRef
46.
Sanader Z, Mitric R, Bonacic-Koutecky V, Bellina B, Antoine R, Dugourd P (2014) The nature of electronic excitations at the metal-bioorganic interface illustrated on histidine-silver hybrids. Phys Chem Chem Phys 16:1257–1261CrossRef
47.
Shi JP, Sun X, Zou XY, Zhang HW (2014) Amino acid-dependent transformations of citrate-coated silver nanoparticles: Impact on morphology, stability and toxicity. Toxicol Lett 229:17–24CrossRef
48.
Hu G, Cai Y, Tu Z, Luo J, Qiao X, Chen Q, Zhang W (2015) Reducing the cytotoxicity while improving the anticancer activity of silver nanoparticles through alpha-tocopherol succinate modification. Rsc Adv 5:82050–82055CrossRef
49.
Lee T-Y, Liu M-S, Huang L-J, Lue S-I, Lin L-C, Kwan A-L, Yang R-C (2013) Bioenergetic failure correlates with autophagy and apoptosis in rat liver following silver nanoparticle intraperitoneal administration. Part Fibre Toxicol 10:1–13CrossRef
50.
Meng F, Zhong Y, Cheng R, Deng C, Zhong Z (2014) pH-sensitive polymeric nanoparticles for tumor-targeting doxorubicin delivery: concept and recent advances. Nanomed Nanotechnol Biol Med 9:487–499
51.
Wojtkowiak JW, Gillies RJ (2012) Autophagy on acid. Autophagy 8:1688–1689CrossRef
52.
Mirolo L, Schmidt T, Eckhardt S, Meuwly M, Fromm KM (2013) pH-dependent coordination of AgI Ions by histidine: Experiment, theory, and a model for SilE. Chem A Eur J 19:1754–1761CrossRef
Metadaten
Titel
Silver nanoparticles with low cytotoxicity: controlled synthesis and surface modification with histidine
verfasst von
Guansong Hu
Guorun Liang
Wen Zhang
Wenxiu Jin
Yan Zhang
Qingyuan Chen
Yuchun Cai
Wanzhong Zhang
Publikationsdatum
28.12.2017
Verlag
Springer US
Erschienen in
Journal of Materials Science / Ausgabe 7/2018
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-017-1940-6

Weitere Artikel der Ausgabe 7/2018

Journal of Materials Science 7/2018 Zur Ausgabe

Polymers

Wool keratin and silk sericin composite films reinforced by molecular network reconstruction

Computation

Computational studies on the absorption enhancement of nanocomposites of tetraphenylporphyrin and graphene quantum dot as sensitizers in solar cell

Composites

In situ chemical vapor deposition of metals on vapor-grown carbon fibers and fabrication of aluminum-matrix composites reinforced by coated fibers

Composites

Preparation and evaluation of magnetic field-induced orientation on magnetic nanoparticles on PVA nanocomposite films

Ceramics

Superhydrophobilization of SiO2 surface with two alkylsilanes for an application in oil/water separation

Polymers

Encapsulation of camphor in cyclodextrin inclusion complex nanofibers via polymer-free electrospinning: enhanced water solubility, high temperature stability, and slow release of camphor

Premium Partner

    Marktübersichten

    Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen. 

    Zur Marktübersicht
    Bildnachweise