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Medical & Biological Engineering & Computing

Erschienen in:

01.07.2006 | Original Article

Micro-CT-based screening of biomechanical and structural properties of bone tissue engineering scaffolds

verfasst von: Tim Van Cleynenbreugel, Jan Schrooten, Hans Van Oosterwyck, Jos Vander Sloten

Erschienen in: Medical & Biological Engineering & Computing | Ausgabe 7/2006

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Abstract

The development of successful scaffolds for bone tissue engineering requires a concurrent engineering approach that combines different research fields. In order to limit in vivo experiments and reduce trial and error research, a scaffold screening technique has been developed. In this protocol seven structural and three biomechanical properties of potential scaffold materials are quantified and compared to the desired values. The property assessment is done on computer models of the scaffolds, and these models are based on micro-CT images. As a proof of principle, three porous scaffolds were evaluated with this protocol: stainless steel, hydroxyapatite, and titanium. These examples demonstrate that the modelling technique is able to quantify important scaffold properties. Thus, a powerful technique for automated screening of bone tissue engineering scaffolds has been developed that in a later stage may be used to tailor the scaffold properties to specific requirements.

Nächster Artikel Biomechanical consequences of progressive marginal bone loss around oral implants: a finite element stress analysis

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Titel: Micro-CT-based screening of biomechanical and structural properties of bone tissue engineering scaffolds
verfasst von: Tim Van Cleynenbreugel
Jan Schrooten
Hans Van Oosterwyck
Jos Vander Sloten
Publikationsdatum: 01.07.2006
Verlag: Springer-Verlag
Erschienen in: Medical & Biological Engineering & Computing / Ausgabe 7/2006
Print ISSN: 0140-0118
Elektronische ISSN: 1741-0444
DOI: https://doi.org/10.1007/s11517-006-0071-z

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