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Erschienen in: Medical & Biological Engineering & Computing 12/2008

01.12.2008 | Original Article

MRI-based anatomical model of the human head for specific absorption rate mapping

verfasst von: Nikos Makris, Leonardo Angelone, Seann Tulloch, Scott Sorg, Jonathan Kaiser, David Kennedy, Giorgio Bonmassar

Erschienen in: Medical & Biological Engineering & Computing | Ausgabe 12/2008

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Abstract

In this study, we present a magnetic resonance imaging (MRI)-based, high-resolution, numerical model of the head of a healthy human subject. In order to formulate the model, we performed quantitative volumetric segmentation on the human head, using T1-weighted MRI. The high spatial resolution used (1 × 1 × 1 mm3), allowed for the precise computation and visualization of a higher number of anatomical structures than provided by previous models. Furthermore, the high spatial resolution allowed us to study individual thin anatomical structures of clinical relevance not visible by the standard model currently adopted in computational bioelectromagnetics. When we computed the electromagnetic field and specific absorption rate (SAR) at 7 Tesla MRI using this high-resolution model, we were able to obtain a detailed visualization of such fine anatomical structures as the epidermis/dermis, bone structures, bone-marrow, white matter and nasal and eye structures.

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Literatur
1.
Zurück zum Zitat Kainz W et al (2005) Dosimetric comparison of the specific anthropomorphic mannequin (SAM) to 14 anatomical head models using a novel definition for the mobile phone positioning. Phys Med Biol 50(14):3423–3445. doi:10.1088/0031-9155/50/14/016 CrossRef Kainz W et al (2005) Dosimetric comparison of the specific anthropomorphic mannequin (SAM) to 14 anatomical head models using a novel definition for the mobile phone positioning. Phys Med Biol 50(14):3423–3445. doi:10.​1088/​0031-9155/​50/​14/​016 CrossRef
2.
Zurück zum Zitat Gandhi OP, Chen XB (1999) Specific absorption rates and induced current densities for an anatomy-based model of the human for exposure to time-varying magnetic fields of MRI. Magn Reson Med 41(4):816–823. doi :10.1002/(SICI)1522-2594(199904)41:4<816::AID-MRM22>3.0.CO;2-5CrossRef Gandhi OP, Chen XB (1999) Specific absorption rates and induced current densities for an anatomy-based model of the human for exposure to time-varying magnetic fields of MRI. Magn Reson Med 41(4):816–823. doi :10.1002/(SICI)1522-2594(199904)41:4<816::AID-MRM22>3.0.CO;2-5CrossRef
4.
Zurück zum Zitat Collins CM, Smith MB (2001) Calculations of B(1) distribution, SNR, and SAR for a surface coil adjacent to an anatomically-accurate human body model. Magn Reson Med 45(4):692–699. doi:10.1002/mrm.1092 CrossRef Collins CM, Smith MB (2001) Calculations of B(1) distribution, SNR, and SAR for a surface coil adjacent to an anatomically-accurate human body model. Magn Reson Med 45(4):692–699. doi:10.​1002/​mrm.​1092 CrossRef
5.
Zurück zum Zitat Christ A et al (2006) Characterization of the electromagnetic near-field absorption in layered biological tissue in the frequency range from 30 MHz to 6, 000 MHz. Phys Med Biol 51(19):4951–4965. doi:10.1088/0031-9155/51/19/014 CrossRef Christ A et al (2006) Characterization of the electromagnetic near-field absorption in layered biological tissue in the frequency range from 30 MHz to 6, 000 MHz. Phys Med Biol 51(19):4951–4965. doi:10.​1088/​0031-9155/​51/​19/​014 CrossRef
8.
Zurück zum Zitat Chou CK et al (1996) Radio frequency electromagnetic exposure: tutorial review on experimental dosimetry. Bioelectromagnetics 17(3):195–208. doi :10.1002/(SICI)1521-186X(1996)17:3<195::AID-BEM5>3.0.CO;2-ZCrossRef Chou CK et al (1996) Radio frequency electromagnetic exposure: tutorial review on experimental dosimetry. Bioelectromagnetics 17(3):195–208. doi :10.1002/(SICI)1521-186X(1996)17:3<195::AID-BEM5>3.0.CO;2-ZCrossRef
10.
Zurück zum Zitat FDA (2003) Criteria for significant risk investigations of magnetic resonance diagnostic devices. Center for Devices and Radiological Health FDA (2003) Criteria for significant risk investigations of magnetic resonance diagnostic devices. Center for Devices and Radiological Health
11.
Zurück zum Zitat IEC (2002) International Standard, medical equipment, part 2–33: particular requirements for the safety of the magnetic resonance equipment for medical diagnosis, 2nd revision. International Electrotechnical Commission 601-2-33, Geneva, p 29–31 IEC (2002) International Standard, medical equipment, part 2–33: particular requirements for the safety of the magnetic resonance equipment for medical diagnosis, 2nd revision. International Electrotechnical Commission 601-2-33, Geneva, p 29–31
12.
Zurück zum Zitat Kunz KS, Luebbers RJ (1993) The finite difference time domain method for electromagnetics. CRC Press, Boca Raton, p 448 Kunz KS, Luebbers RJ (1993) The finite difference time domain method for electromagnetics. CRC Press, Boca Raton, p 448
13.
Zurück zum Zitat Taflove A, Hagness SC (2000) Computational electrodynamics: the finite-difference time-domain method. Artech House, BostonMATH Taflove A, Hagness SC (2000) Computational electrodynamics: the finite-difference time-domain method. Artech House, BostonMATH
15.
Zurück zum Zitat Testut L, Jacob O (1974) Trattato di Anatomia Topografica con applicazioni medico-chirurgiche, ed UTET. Turin, Italy Testut L, Jacob O (1974) Trattato di Anatomia Topografica con applicazioni medico-chirurgiche, ed UTET. Turin, Italy
17.
Zurück zum Zitat Fawcett D, Jensh R (2002) Bloom and Fawcett’s concise histology, 2nd edn. H. Arnold. London Fawcett D, Jensh R (2002) Bloom and Fawcett’s concise histology, 2nd edn. H. Arnold. London
18.
Zurück zum Zitat Gray H, Williams PL (2092) Bannister LH (1995) Gray’s anatomy: the anatomical basis of medicine and surgery, 38th edn. Churchill Livingstone, New York, p 2092 Gray H, Williams PL (2092) Bannister LH (1995) Gray’s anatomy: the anatomical basis of medicine and surgery, 38th edn. Churchill Livingstone, New York, p 2092
19.
Zurück zum Zitat v Vorst AA Rosen, Kotsuka Y (2006) RF/microwave interaction with biological tissues. In: Wiley series in microwave and optical engineering. Wiley, Hoboken, xiii, p 330 v Vorst AA Rosen, Kotsuka Y (2006) RF/microwave interaction with biological tissues. In: Wiley series in microwave and optical engineering. Wiley, Hoboken, xiii, p 330
21.
Zurück zum Zitat Collins CM, Liu W, Wang J, Gruetter R, Vaughan JT, Ugurbil K, Smith MB (2004) Temperature and SAR calculations for a human head within volume and surface coils at 64 and 300 MHz. J Magn Reson Imaging 19:650–656CrossRef Collins CM, Liu W, Wang J, Gruetter R, Vaughan JT, Ugurbil K, Smith MB (2004) Temperature and SAR calculations for a human head within volume and surface coils at 64 and 300 MHz. J Magn Reson Imaging 19:650–656CrossRef
22.
Zurück zum Zitat DeMarco SC, Lazzi G, Liu W, Weiland JD, Humayun MS (2003) Computed SAR and thermal elevation in a 0.25 mm 2-D model of the human eye and head in response to an implanted retinal stimulator—part I: models and methods. Antennas and propagation. IEEE Trans 51:2274–2285 DeMarco SC, Lazzi G, Liu W, Weiland JD, Humayun MS (2003) Computed SAR and thermal elevation in a 0.25 mm 2-D model of the human eye and head in response to an implanted retinal stimulator—part I: models and methods. Antennas and propagation. IEEE Trans 51:2274–2285
23.
Zurück zum Zitat Li QX, Gandhi OP (2006) Thermal implications of the new relaxed IEEE RF safety standard for head exposures to cellular telephones at 835 and 1,900 MHz. IEEE Trans Microw Theory Tech 54:3146–3154CrossRef Li QX, Gandhi OP (2006) Thermal implications of the new relaxed IEEE RF safety standard for head exposures to cellular telephones at 835 and 1,900 MHz. IEEE Trans Microw Theory Tech 54:3146–3154CrossRef
27.
Zurück zum Zitat Jin J-M (1999) Electromagnetic analysis and design in magnetic resonance imaging. Biomedical engineering series. CRC Press, Boca Raton, xiv, p 282 Jin J-M (1999) Electromagnetic analysis and design in magnetic resonance imaging. Biomedical engineering series. CRC Press, Boca Raton, xiv, p 282
28.
Zurück zum Zitat Collins CM et al (2005) Central brightening due to constructive interference with, without, and despite dielectric resonance. J Magn Reson Imaging 21(2):192–196. doi:10.1002/jmri.20245 CrossRef Collins CM et al (2005) Central brightening due to constructive interference with, without, and despite dielectric resonance. J Magn Reson Imaging 21(2):192–196. doi:10.​1002/​jmri.​20245 CrossRef
29.
Zurück zum Zitat Blinkov SM, Glezer IëI (1968) The human brain in figures and tables; a quantitative handbook. Basic Books, New York, xxxii, p 482 Blinkov SM, Glezer IëI (1968) The human brain in figures and tables; a quantitative handbook. Basic Books, New York, xxxii, p 482
30.
Zurück zum Zitat Chrzanowska G, Beben A (1973) Weight of the brain and body height in man between the ages of 20 and 89 years. Folia Morphol (Warsz) 32(4):391–406 Chrzanowska G, Beben A (1973) Weight of the brain and body height in man between the ages of 20 and 89 years. Folia Morphol (Warsz) 32(4):391–406
31.
Zurück zum Zitat Debakan A, Sadowsky D (1978) Changes in brain weight during the span of human life: relation of brain weights and body heights and body weights. Ann Neurol 4:345–356. doi:10.1002/ana.410040410 CrossRef Debakan A, Sadowsky D (1978) Changes in brain weight during the span of human life: relation of brain weights and body heights and body weights. Ann Neurol 4:345–356. doi:10.​1002/​ana.​410040410 CrossRef
32.
Zurück zum Zitat Hwang YI et al (1995) Study on the Korean adult cranial capacity. J Korean Med Sci 10:239–242 Hwang YI et al (1995) Study on the Korean adult cranial capacity. J Korean Med Sci 10:239–242
33.
Zurück zum Zitat Miller A et al (1980) Spectral analysis of arterial bruits (phonoangiography): experimental validation. Circulation 61(3):515–520 Miller A et al (1980) Spectral analysis of arterial bruits (phonoangiography): experimental validation. Circulation 61(3):515–520
34.
Zurück zum Zitat Peters M, Jancke L, Zilles K (2000) Comparison of overall brain volume and midsagittal corpus callosum surface area as obtained from NMR scans and direct anatomical measures: a within-subject study on autopsy brains. Neuropsychologia 38(10):1375–1381. doi:10.1016/S0028-3932(00)00048-8 CrossRef Peters M, Jancke L, Zilles K (2000) Comparison of overall brain volume and midsagittal corpus callosum surface area as obtained from NMR scans and direct anatomical measures: a within-subject study on autopsy brains. Neuropsychologia 38(10):1375–1381. doi:10.​1016/​S0028-3932(00)00048-8 CrossRef
35.
Zurück zum Zitat Svennerholm L, Bostrom K, Jungbjer B (1997) Changes in weight and compositions of major membrane components of human brain during the span of adult human life of Swedes. Acta Neuropathol 94(4):345–352. doi:10.1007/s004010050717 CrossRef Svennerholm L, Bostrom K, Jungbjer B (1997) Changes in weight and compositions of major membrane components of human brain during the span of adult human life of Swedes. Acta Neuropathol 94(4):345–352. doi:10.​1007/​s004010050717 CrossRef
40.
Zurück zum Zitat Visible_Human_Project (1996) The visible human project. US National Library of Medicine Visible_Human_Project (1996) The visible human project. US National Library of Medicine
43.
Zurück zum Zitat Schnitzlein H, Murtagh F (1985) Imaging anatomy of the head and spine: a photographic color Atlas of MRI, CT, gross and microscopic anatomy in axial, coronal and sagital planes. Urban & Schwarzenberg, Munich Schnitzlein H, Murtagh F (1985) Imaging anatomy of the head and spine: a photographic color Atlas of MRI, CT, gross and microscopic anatomy in axial, coronal and sagital planes. Urban & Schwarzenberg, Munich
44.
Zurück zum Zitat Bit-Babik G et al (2005) Simulation of exposure and SAR estimation for adult and child heads exposed to radiofrequency energy from portable communication devices. Radiat Res 163(5):580–590. doi:10.1667/RR3353 CrossRef Bit-Babik G et al (2005) Simulation of exposure and SAR estimation for adult and child heads exposed to radiofrequency energy from portable communication devices. Radiat Res 163(5):580–590. doi:10.​1667/​RR3353 CrossRef
45.
Zurück zum Zitat Collins CM, Smith MB (2003) Spatial resolution of numerical models of man and calculated specific absorption rate using the FDTD method: a study at 64 MHz in a magnetic resonance imaging coil. J Magn Reson Imaging 18(3):383–388. doi:10.1002/jmri.10359 CrossRef Collins CM, Smith MB (2003) Spatial resolution of numerical models of man and calculated specific absorption rate using the FDTD method: a study at 64 MHz in a magnetic resonance imaging coil. J Magn Reson Imaging 18(3):383–388. doi:10.​1002/​jmri.​10359 CrossRef
46.
Zurück zum Zitat NCRP (1981) Radiofrequency electromagnetic fields: properties, quantities and units, biophysical interaction, and measurement. National Council Radiation Protection and Measurements, Bethesda NCRP (1981) Radiofrequency electromagnetic fields: properties, quantities and units, biophysical interaction, and measurement. National Council Radiation Protection and Measurements, Bethesda
47.
48.
Zurück zum Zitat Kong JA (1990) Electromagnetic wave theory, 2nd edn. Wiley, New York, xi, p 704 Kong JA (1990) Electromagnetic wave theory, 2nd edn. Wiley, New York, xi, p 704
50.
Zurück zum Zitat Fisel CR et al (1989) A general model for susceptibility-based MR contrast. In: Eighth annual meeting of the society of magnetic resonance in medicine. Amsterdam, The Netherlands Fisel CR et al (1989) A general model for susceptibility-based MR contrast. In: Eighth annual meeting of the society of magnetic resonance in medicine. Amsterdam, The Netherlands
53.
Zurück zum Zitat Gabriel C (2005) Dielectric properties of biological tissue: variation with age. Bioelectromagnetics Suppl 7:S12–S18 Gabriel C (2005) Dielectric properties of biological tissue: variation with age. Bioelectromagnetics Suppl 7:S12–S18
54.
Zurück zum Zitat Foster KR, Schwan HP (1989) Dielectric properties of tissues and biological materials: a critical review. Crit Rev Biomed Eng 17(1):25–104 Foster KR, Schwan HP (1989) Dielectric properties of tissues and biological materials: a critical review. Crit Rev Biomed Eng 17(1):25–104
55.
56.
Zurück zum Zitat Katscher U et al (2006) Electric properties tomography (EPT) via MRI. In: ISMRM Fourteenth Scientific Meeting. Seattle Katscher U et al (2006) Electric properties tomography (EPT) via MRI. In: ISMRM Fourteenth Scientific Meeting. Seattle
57.
Zurück zum Zitat Hurt W, Ziriax J, Mason P (2000) Variability in EMF permittivity values: implications for SAR calculations. IEEE Trans Biomed Eng 47(3):396–401CrossRef Hurt W, Ziriax J, Mason P (2000) Variability in EMF permittivity values: implications for SAR calculations. IEEE Trans Biomed Eng 47(3):396–401CrossRef
58.
Zurück zum Zitat Mason P et al (2000) Effects of frequency, permittivity, and voxel size on predicted specific absorption rate values in biological tissue during electromagnetic—field exposure. IEEE Trans Microw Theory 48:2050–2058. doi:10.1109/22.884194 CrossRef Mason P et al (2000) Effects of frequency, permittivity, and voxel size on predicted specific absorption rate values in biological tissue during electromagnetic—field exposure. IEEE Trans Microw Theory 48:2050–2058. doi:10.​1109/​22.​884194 CrossRef
59.
Zurück zum Zitat Kang G, Gandhi OP (2004) Effect of dielectric properties on the peak 1 and 10 g SAR fro 802.11 a/b/g Frequencies 2.45 and 5.15 to 5.85 GHz. IEEE Trans Electromagn Compat 46:268–274. doi:10.1109/TEMC.2004.826875 CrossRef Kang G, Gandhi OP (2004) Effect of dielectric properties on the peak 1 and 10 g SAR fro 802.11 a/b/g Frequencies 2.45 and 5.15 to 5.85 GHz. IEEE Trans Electromagn Compat 46:268–274. doi:10.​1109/​TEMC.​2004.​826875 CrossRef
60.
Zurück zum Zitat Van den Berg CAT (2006) Radiofrequency fields in hyperthermia and MRI. Exploiting their similarities for mutual benefits. Utrecht Van den Berg CAT (2006) Radiofrequency fields in hyperthermia and MRI. Exploiting their similarities for mutual benefits. Utrecht
63.
Zurück zum Zitat Ayache N (ed) (2004) Computational models for the human body. In:Ciarlet P (ed) Handbook of numerical analysis. Elsevier, Amsterdam, p 670 Ayache N (ed) (2004) Computational models for the human body. In:Ciarlet P (ed) Handbook of numerical analysis. Elsevier, Amsterdam, p 670
Metadaten
Titel
MRI-based anatomical model of the human head for specific absorption rate mapping
verfasst von
Nikos Makris
Leonardo Angelone
Seann Tulloch
Scott Sorg
Jonathan Kaiser
David Kennedy
Giorgio Bonmassar
Publikationsdatum
01.12.2008
Verlag
Springer-Verlag
Erschienen in
Medical & Biological Engineering & Computing / Ausgabe 12/2008
Print ISSN: 0140-0118
Elektronische ISSN: 1741-0444
DOI
https://doi.org/10.1007/s11517-008-0414-z

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