Skip to main content
Erschienen in: Medical & Biological Engineering & Computing 4/2017

17.06.2016 | Original Article

Geometry reconstruction method for patient-specific finite element models for the assessment of tibia fracture risk in osteogenesis imperfecta

verfasst von: Christiane Caouette, Nicole Ikin, Isabelle Villemure, Pierre-Jean Arnoux, Frank Rauch, Carl-Éric Aubin

Erschienen in: Medical & Biological Engineering & Computing | Ausgabe 4/2017

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Lower limb deformation in children with osteogenesis imperfecta (OI) impairs ambulation and may lead to fracture. Corrective surgery is based on empirical assessment criteria. The objective was to develop a reconstruction method of the tibia for OI patients that could be used as input of a comprehensive finite element model to assess fracture risks. Data were obtained from three children with OI and tibia deformities. Four pQCT scans were registered to biplanar radiographs, and a template mesh was deformed to fit the bone outline. Cortical bone thickness was computed. Sensitivity of the model to missing slices of pQCT was assessed by calculating maximal von Mises stress for a vertical hopping load case. Sensitivity of the model to ±5 % of cortical thickness measurements was assessed by calculating loads at fracture. Difference between the mesh contour and bone outline on the radiographs was below 1 mm. Removal of one pQCT slice increased maximal von Mises stress by up to 10 %. Simulated ±5 % variation of cortical bone thickness leads to variations of up to 4.1 % on predicted fracture loads. Using clinically available tibia imaging from children with OI, the developed reconstruction method allowed the building of patient-specific finite element models.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Literatur
9.
Zurück zum Zitat Caouette C, Rauch F, Villemure I, Arnoux PJ, Gdalevitch M, Veilleux LN, Heng JL, Aubin CE (2014) Biomechanical analysis of fracture risk associated with tibia deformity in children with osteogenesis imperfecta: a finite element analysis. J Musculoskelet Neuronal Interact 14:205–212. doi:10.3410/f.718465268.793509190 PubMed Caouette C, Rauch F, Villemure I, Arnoux PJ, Gdalevitch M, Veilleux LN, Heng JL, Aubin CE (2014) Biomechanical analysis of fracture risk associated with tibia deformity in children with osteogenesis imperfecta: a finite element analysis. J Musculoskelet Neuronal Interact 14:205–212. doi:10.​3410/​f.​718465268.​793509190 PubMed
10.
Zurück zum Zitat Chaibi Y, Cresson T, Aubert B, Hausselle J, Neyret P, Hauger O, de Guise JA, Skalli W (2011) Fast 3D reconstruction of the lower limb using a parametric model and statistical inferences and clinical measurements calculation from biplanar X-rays. Comput Methods Biomech Biomed Eng 15:457–466. doi:10.1080/10255842.2010.540758 CrossRef Chaibi Y, Cresson T, Aubert B, Hausselle J, Neyret P, Hauger O, de Guise JA, Skalli W (2011) Fast 3D reconstruction of the lower limb using a parametric model and statistical inferences and clinical measurements calculation from biplanar X-rays. Comput Methods Biomech Biomed Eng 15:457–466. doi:10.​1080/​10255842.​2010.​540758 CrossRef
11.
12.
Zurück zum Zitat Delorme S, Petit Y, de Guise JA, Labelle H, Aubin CE, Dansereau J (2003) Assessment of the 3-D reconstruction and high-resolution geometrical modeling of the human skeletal trunk from 2-D radiographic images. IEEE Trans Biomed Eng 50:989–998. doi:10.1109/tbme.2003.814525 CrossRefPubMed Delorme S, Petit Y, de Guise JA, Labelle H, Aubin CE, Dansereau J (2003) Assessment of the 3-D reconstruction and high-resolution geometrical modeling of the human skeletal trunk from 2-D radiographic images. IEEE Trans Biomed Eng 50:989–998. doi:10.​1109/​tbme.​2003.​814525 CrossRefPubMed
13.
14.
Zurück zum Zitat Fan Z, Smith PA, Harris GF, Rauch F, Bajorunaite R (2007) Comparison of nanoindentation measurements between osteogenesis imperfecta Type III and Type IV and between different anatomic locations (femur/tibia versus iliac crest). Connect Tissue Res 48:70–75. doi:10.1080/03008200601090949 CrossRefPubMed Fan Z, Smith PA, Harris GF, Rauch F, Bajorunaite R (2007) Comparison of nanoindentation measurements between osteogenesis imperfecta Type III and Type IV and between different anatomic locations (femur/tibia versus iliac crest). Connect Tissue Res 48:70–75. doi:10.​1080/​0300820060109094​9 CrossRefPubMed
16.
Zurück zum Zitat Folkestad L, Hald JD, Hansen S, Gram J, Langdahl B, Abrahamsen B, Brixen K (2012) Bone geometry, density, and microarchitecture in the distal radius and tibia in adults with osteogenesis imperfecta type I assessed by high-resolution pQCT. J Bone Miner Res 27:1405–1412. doi:10.1002/jbmr.1592 CrossRefPubMed Folkestad L, Hald JD, Hansen S, Gram J, Langdahl B, Abrahamsen B, Brixen K (2012) Bone geometry, density, and microarchitecture in the distal radius and tibia in adults with osteogenesis imperfecta type I assessed by high-resolution pQCT. J Bone Miner Res 27:1405–1412. doi:10.​1002/​jbmr.​1592 CrossRefPubMed
19.
Zurück zum Zitat Garo A, Arnoux PJ, Wagnac E, Aubin CE (2011) Calibration of the mechanical properties in a finite element model of a lumbar vertebra under dynamic compression up to failure. Med Biol Eng Comput 49:1371–1379. doi:10.1007/s11517-011-0826-z CrossRefPubMed Garo A, Arnoux PJ, Wagnac E, Aubin CE (2011) Calibration of the mechanical properties in a finite element model of a lumbar vertebra under dynamic compression up to failure. Med Biol Eng Comput 49:1371–1379. doi:10.​1007/​s11517-011-0826-z CrossRefPubMed
22.
Zurück zum Zitat Hafner BJ, Zachariah SG, Sanders JE (2000) Characterisation of three-dimensional anatomic shapes using principal components: application to the proximal tibia. Med Biol Eng Comput 38:9–16. doi:10.1007/BF02344682 CrossRefPubMed Hafner BJ, Zachariah SG, Sanders JE (2000) Characterisation of three-dimensional anatomic shapes using principal components: application to the proximal tibia. Med Biol Eng Comput 38:9–16. doi:10.​1007/​BF02344682 CrossRefPubMed
23.
Zurück zum Zitat Hraiech N, Boichon C, Rochette M, Marchal T, Horner M (2010) Statistical shape modeling of femurs using morphing and principal component analysis. J Med Dev 4:027531–027534 Hraiech N, Boichon C, Rochette M, Marchal T, Horner M (2010) Statistical shape modeling of femurs using morphing and principal component analysis. J Med Dev 4:027531–027534
24.
Zurück zum Zitat Imbert L, Aurégan J-C, Pernelle K, Hoc T (2015) Microstructure and compressive mechanical properties of cortical bone in children with osteogenesis imperfecta treated with bisphosphonates compared with healthy children. J Mech Behav Biomed Mater 46:261–270. doi:10.1016/j.jmbbm.2014.12.020 CrossRefPubMed Imbert L, Aurégan J-C, Pernelle K, Hoc T (2015) Microstructure and compressive mechanical properties of cortical bone in children with osteogenesis imperfecta treated with bisphosphonates compared with healthy children. J Mech Behav Biomed Mater 46:261–270. doi:10.​1016/​j.​jmbbm.​2014.​12.​020 CrossRefPubMed
25.
Zurück zum Zitat Land C, Rauch F, Glorieux FH (2006) Cyclical intravenous pamidronate treatment affects metaphyseal modeling in growing patients with osteogenesis imperfecta. J Bone Miner Res 21:374–379. doi:10.1359/jbmr.051207 CrossRefPubMed Land C, Rauch F, Glorieux FH (2006) Cyclical intravenous pamidronate treatment affects metaphyseal modeling in growing patients with osteogenesis imperfecta. J Bone Miner Res 21:374–379. doi:10.​1359/​jbmr.​051207 CrossRefPubMed
26.
Zurück zum Zitat Laporte S, Skalli W, de Guise JA, Lavaste F, Mitton D (2003) A biplanar reconstruction method based on 2D and 3D contours: application to the distal femur. Comput Methods Biomech Biomed Eng 6:1–6. doi:10.1080/1025584031000065956 CrossRef Laporte S, Skalli W, de Guise JA, Lavaste F, Mitton D (2003) A biplanar reconstruction method based on 2D and 3D contours: application to the distal femur. Comput Methods Biomech Biomed Eng 6:1–6. doi:10.​1080/​1025584031000065​956 CrossRef
31.
Zurück zum Zitat Rauch F, Glorieux FH (2006) Treatment of children with osteogenesis imperfecta. Curr Osteoporos Rep 4:159–164CrossRefPubMed Rauch F, Glorieux FH (2006) Treatment of children with osteogenesis imperfecta. Curr Osteoporos Rep 4:159–164CrossRefPubMed
34.
Zurück zum Zitat Schileo E, Taddei F, Cristofolini L, Viceconti M (2008) Subject-specific finite element models implementing a maximum principal strain criterion are able to estimate failure risk and fracture location on human femurs tested in vitro. J Biomech 41:356–367. doi:10.1016/j.jbiomech.2007.09.009 CrossRefPubMed Schileo E, Taddei F, Cristofolini L, Viceconti M (2008) Subject-specific finite element models implementing a maximum principal strain criterion are able to estimate failure risk and fracture location on human femurs tested in vitro. J Biomech 41:356–367. doi:10.​1016/​j.​jbiomech.​2007.​09.​009 CrossRefPubMed
41.
Zurück zum Zitat Wagnac E, Arnoux PJ, Garo A, Aubin CE (2012) Finite element analysis of the influence of loading rate on a model of the full lumbar spine under dynamic loading conditions. Med Biol Eng Comput 50:903–915. doi:10.1007/s11517-012-0908-6 CrossRefPubMed Wagnac E, Arnoux PJ, Garo A, Aubin CE (2012) Finite element analysis of the influence of loading rate on a model of the full lumbar spine under dynamic loading conditions. Med Biol Eng Comput 50:903–915. doi:10.​1007/​s11517-012-0908-6 CrossRefPubMed
42.
Zurück zum Zitat Wang W, Aubin CE, Cahill P, Baran G, Arnoux PJ, Parent S, Labelle H (2015) Biomechanics of high-grade spondylolisthesis with and without reduction. Med Biol Eng Comput. doi:10.1007/s11517-015-1353-0 Wang W, Aubin CE, Cahill P, Baran G, Arnoux PJ, Parent S, Labelle H (2015) Biomechanics of high-grade spondylolisthesis with and without reduction. Med Biol Eng Comput. doi:10.​1007/​s11517-015-1353-0
44.
Zurück zum Zitat Zheng G (2010) Statistical shape model-based reconstruction of a scaled, patient-specific surface model of the pelvis from a single standard AP X-ray radiograph. Med Phys 37:1424–1439. doi:10.1118/1.3327453 CrossRefPubMed Zheng G (2010) Statistical shape model-based reconstruction of a scaled, patient-specific surface model of the pelvis from a single standard AP X-ray radiograph. Med Phys 37:1424–1439. doi:10.​1118/​1.​3327453 CrossRefPubMed
Metadaten
Titel
Geometry reconstruction method for patient-specific finite element models for the assessment of tibia fracture risk in osteogenesis imperfecta
verfasst von
Christiane Caouette
Nicole Ikin
Isabelle Villemure
Pierre-Jean Arnoux
Frank Rauch
Carl-Éric Aubin
Publikationsdatum
17.06.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Medical & Biological Engineering & Computing / Ausgabe 4/2017
Print ISSN: 0140-0118
Elektronische ISSN: 1741-0444
DOI
https://doi.org/10.1007/s11517-016-1526-5

Weitere Artikel der Ausgabe 4/2017

Medical & Biological Engineering & Computing 4/2017 Zur Ausgabe

Premium Partner