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Erschienen in:

2018 | OriginalPaper | Buchkapitel

8. Liquid Metal Enabled Injectable Biomedical Electronics

verfasst von : Jing Liu, Liting Yi

Erschienen in: Liquid Metal Biomaterials

Verlag: Springer Singapore

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Abstract

In clinics, a medical device is defined as implantable if it is either partly or totally introduced, surgically or medically into the human body and is intended to remain there after the procedure. By virtue of characteristics of well controlled wettability, high electrical conductivity, low cost and easy operation, liquid metal materials have been developed into above area in recent years. In this chapter, representative strategies to develop liquid metals as implantable or injectable medical electronics were introduced and discussed.

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Kim DH, Viventi J, Amsden JJ et al (2010) Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics. Nat Mater 9(6):511–517CrossRef

Jiang G, Zhou DD (2010) Technology advances and challenges in hermetic packaging for implantable medical devices. In: Implantable neural prostheses 2: techniques and engineering approaches. Springer, Berlin, pp 28–61

Bazaka K, Jacob MV (2013) Implantable devices: issues and challenges. Electronics 2(1):1–34

ISO 13485 (2003) Medical devices-quality management systems-requirements for regulatory purposes. Geneva, Switzerland. http://www.iso.org/iso/catalogue_detail?csnumber=36786

Viventi J, Kim DH, Moss JD et al (2010) A conformal, bio-interfaced class of silicon electronics for mapping cardiac electrophysiology. Sci Transl Med 2(24):24ra22CrossRef

Kim DH, Ahn JH, Choi WM et al (2008) Strechable and foldable silicon integrated circuits. Science 320(5875):507–511CrossRef

Irnich W (2002) Electronic security systems and active implantable medical devices. Pacing Clin Electrophysiol Pace 25(8):1235–1258CrossRef

Adunka O, Kiefer J, Unkelbach MH et al (2010) Development and evaluation of an improved cochlear implant electrode design for electric acoustic stimulation. Laryngoscope 114(114):1237–1241

Halperin D, Heydt-Benjamin TS, Fu K et al (2008) Security and privacy for implantable medical devices. Pervasive Comput 7:30–39CrossRef

10.

Grill WM, Norman SE, Bellamkonda RV (2009) Implanted neural interfaces: biochallenges and engineered solutions. Annu Rev Biomed Eng 11(11):1–24CrossRef

11.

Fountas KN, Kapsalaki E, Hadjigeorgiou G (2010) Cerebellar stimulation in the management of medically intractable epilepsy: a systematic and critical review. Neurosurg Focus 29(2):E8CrossRef

12.

Zrenner E (2002) Will retinal implants restore vision? Science 295(5557):1022–1025CrossRef

13.

Magjarević R, Ferekpetrić B (2010) Implantable cardiac pacemakers-50 years from the first implantation. Zdravniški Vestnik 79(1):55–67

14.

Gelinck GH, Huitema HEA, Veenendaal EV et al (2004) Flexible active-matrix displays and shift registers based on solution-processed organic transistors. Nat Mat 3(2):106–110CrossRef

15.

Onuki Y, Bhardwaj U, Papadimitrakopoulos F et al (2008) A review of the biocompatibility of implantable devices: current challenges to overcome foreign body response. J Diab Sci Technol 2(6):1003–1015CrossRef

16.

Cameron T, Liinamaa TL, Loeb GE et al (1998) Long-term biocompatibility of a miniature stimulator implanted in feline hind limb muscles. IEEE Trans Biomed Eng 45(8):1024–1035CrossRef

17.

Williams DF (2008) On the mechanisms of biocompatibility. Biomaterials 29(20):2941–2953CrossRef

18.

International Organization for Standardization ISO 10993. Biological evaluation of medical devices. Part 1: evaluation and testing within a risk management process. Geneva: ISO, 2009

19.

Joung YH (2013) Development of implantable medical devices: from an engineering perspective. Int Neurourol J 17(3):98–106CrossRef

20.

Thomas RW (1976) Moisture, myths, and microcircuits. IEEE Trans Parts Hybrids Packag 12(3):167–171CrossRef

21.

Chlebowski AL, Chow EY, Ellison C et al (2012) Integrated LTCC packaging for use in biomedical devices. Biomed Mater Eng 22(6):361–372

22.

Kim SJ, Lee DS, Kim IG et al (2012) Evaluation of the biocompatibility of a coating material for an implantable bladder volume sensor. Kaohsiung J Med Sci 28(3):123–129CrossRef

23.

Chen GQ (2011) Biofunctionalization of polymers and their applications. Adv Biochem Eng Biotechnol 125(125):29–45

24.

Guenther T, Dodds CWD, Lovell NH et al. (2011) Chip-scale hermetic feedthroughs for implantable bionics. In: International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, pp 6717–6720

25.

Qin Y, Howlader MMR, Deen MJ et al (2014) Polymer integration for packaging of implantable sensors. Sens Actuators B Chem 202(10):758–778CrossRef

26.

Hwang GT, Im D, Lee SE et al (2013) In vivo silicon-based flexible radio frequency integrated circuits monolithically encapsulated with biocompatible liquid crystal polymers. ACS Nano 7(5):4545–4553CrossRef

27.

Ha D, Kim BG, Lin TY et al. (2010) 3D packaging technique on liquid crystal polymer (LCP) for miniature wireless biomedical sensor. In: Microwave Symposium Digest. IEEE, pp 612–615

28.

White TJ, Broer DJ (2015) Programmable and adaptive mechanics with liquid crystal polymer networks and elastomers. Nat Mater 14(11):1087CrossRef

29.

Kim S, Bhandari R, Klein M et al (2009) Integrated wireless neural interface based on the Utah electrode array. Biomed Microdevice 11(2):453–466CrossRef

30.

Ryu SI, Shenoy KV (2009) Human cortical prostheses: lost in translation? Neurosurg Focus 27(1):E5CrossRef

31.

Schalk G, Miller KJ, Anderson NR et al (2008) Two-dimensional movement control using electrocorticographic signals in humans. J Neural Eng 5(1):75CrossRef

32.

So JH, Thelen J, Qusba A et al (2009) Reversibly deformable and mechanically tunable fluidic antennas. Adv Func Mater 19(22):3632–3637CrossRef

33.

Zhang Q, Zheng Y, Liu J (2012) Direct writing of electronics based on alloy and metal (DREAM) ink: a newly emerging area and its impact on energy, environment and health sciences. Front Energy 6(4):311–340CrossRef

34.

Zheng Y, He Z, Gao Y et al (2013) Direct desktop printedcircuits—on-paper flexible electronics. Sci Rep 3(5):759–762

35.

Wang L, Liu J (2014) Compatible hybrid 3D printing of metal and nonmetal inks for direct manufacture of end functional devices. Sci China Technol Sci 57(11):2089–2095CrossRef

36.

Jin C, Zhang J, Li X et al (2013) Injectable 3-D fabrication of medical electronics at the target biological tissues. Sci Rep 3:3342CrossRef

37.

Butson CR, Maks CB, Mcintyre CC (2006) Sources and effects of electrode impedance during deep brain stimulation. Clin Neurophysiol 117(2):447CrossRef

38.

Chu V, Otero JM, Lopez O et al (2001) Method for non-invasively recording electrocardiograms in conscious mice. BMC Physiol 1(1):6CrossRef

39.

Salama G, London B (2007) Mouse models of long QT syndrome. J Physiol 578(1):43–53CrossRef

40.

Sun X, Yuan B, Rao W, Liu J (2017) Amorphous liquid metal electrodes enabled conformable electrochemical therapy of tumors. Biomaterials 146:156–167CrossRef

41.

Cabrales LB, Ciria HC, Bruzón RP et al (2001) Electrochemical treatment of mouse Ehrlich tumor with direct electric current. Bioelectromagnetics 22:316–322CrossRef

42.

Wemyss-Holden SA, Robertson GS, Dennison AR et al (2000) Electrochemical lesions in the rat liver support its potential for treatment of liver tumors. J Surg Res 93:55–62CrossRef

43.

Czymek R, Nassrallah J, Gebhard M et al (2012) Intrahepatic radiofrequency ablation versus electrochemical treatment in vivo. Surg Oncol 21:79–86CrossRef

44.

Keisari Y, Hochman I, Confino H, Korenstein R, Kelson I (2014) Activation of local and systemic anti-tumor immune responses by ablation of solid tumors with intratumoral electrochemical or alpha radiation treatments. Cancer Immunol Immunother 63:1–9CrossRef

45.

Nilsson E, von Euler H, Berendson J et al (2000) Electrochemical treatment of tumours. Bioelectrochemistry 51:1–11CrossRef

46.

Li K, Xin Y, Gu Y, Xu B, Fan D, Ni B (1997) Effects of direct current on dog liver: possible mechanisms for tumor electrochemical treatment. Bioelectromagnetics 18:2–7CrossRef

47.

Xin Y, Xue F, Ge B, Zhao F, Shi B, Zhang W (1997) Electrochemical treatment of lung cancer. Bioelectromagnetics 18:8–13CrossRef

48.

Li J, Xin Y, Fan X, Chen J, Wang J, Zhou J (2013) Effect of electrochemotherapy in treating patients with venous malformations. Chinese J integr Med 19:387–393CrossRef

49.

Yen Y, Li J, Zhou B, Rojas F, Yu J, Chou C (1999) Electrochemical treatment of human KB cells in vitro. Bioelectromagnetics 20:34–41CrossRef

50.

Nilsson E, Fontes E (2001) Mathematical modelling of physicochemical reactions and transport processes occurring around a platinum cathode during the electrochemical treatment of tumours. Bioelectrochemistry 53:213–224CrossRef

51.

Cury FL, Bhindi B, Rocha J et al (2015) Electrochemical red-ox therapy of prostate cancer in nude mice. Bioelectrochemistry 104:1–9CrossRef

52.

Belyy Y, Tereshchenko A, Shatskih A (2012) Electrochemical lysis of an intraocular tumour using a combination of electrode placements. Ecancermedicalscience 6:272

53.

Czymek R, Dinter D, Löffler S et al (2011) Electrochemical treatment: An investigation of dose-response relationships using an isolated liver perfusion model. Saudi J Gastroenterol 17:335CrossRef

54.

Ren RL, Vora N, Yang F et al (2001) Variations of dose and electrode spacing for rat breast cancer electrochemical treatment. Bioelectromagnetics 22:205–211CrossRef

55.

von Euler H, Nilsson E, Olsson JM, Lagerstedt AS (2001) Electrochemical treatment (EChT) effects in rat mammary and liver tissue. In vivo optimizing of a dose-planning model for EChT of tumours. Bioelectrochemistry 54:117–124CrossRef

56.

Jin C, Zhang J, Li X, Yang X, Li J, Liu J (2013) Injectable 3-D fabrication of medical electronics at the target biological tissues. Sci Rep 3(6163):3442CrossRef

57.

Liu J, Fu TM, Cheng Z et al (2015) Syringe-injectable electronics. Nat Nanotechnol 10:629–636CrossRef

58.

Hong G, Fu TM, Zhou T, Schuhmann TG, Huang J, Lieber CM (2015) Syringe injectable electronics: Precise targeted delivery with quantitative input/output connectivity. Nano Lett 15:6979–6984CrossRef

59.

Kim DH, Lee Y (2015) Bioelectronics: injection and unfolding. Nat Nanotechnol 10:570–571CrossRef

60.

Sheng L, Zhang J, Liu J (2014) Diverse transformations of liquid metals between different morphologies. Adv Mater 26:6036–6042CrossRef

61.

Zhang J, Sheng L, Liu J (2014) Synthetically chemical-electrical mechanism for controlling large scale reversible deformation of liquid metal objects. Sci Rep 4:7116CrossRef

62.

Liu T, Sen P, Kim CJ (2012) Characterization of nontoxic liquid-metal alloy galinstan for applications in microdevices. J Microelectromech Syst 21:443–450CrossRef

63.

Saiz E, Tomsia AP (2004) Atomic dynamics and Marangoni films during liquid-metal spreading. Nat Mater 3:903–909CrossRef

64.

Zavabeti A, Daeneke T, Chrimes AF et al (2016) Ionic imbalance induced self-propulsion of liquid metals. Nat Commun 7:12402CrossRef

65.

Wójcicki M, Drozdzik M, Olewniczak S et al (2000) Antitumor effect of electrochemical therapy on transplantable mouse cancers. Med Sci Monit 6:498–502

66.

Turk B, Bieth JG, Björk I et al (1995) Regulation of the activity of lysosomal cysteine proteinases by pH-induced inactivation and/or endogenous protein inhibitors, cystatins. Bio Chem Hoppe-Seyler 376:225–230CrossRef

67.

Kroemer G, Jäättelä M (2005) Lysosomes and autophagy in cell death control. Nat Rev Cancer 5:886CrossRef

68.

von Euler H, Olsson JM, Hultenby K, Thörne A, Lagerstedt AS (2003) Animal models for treatment of unresectable liver tumours: a histopathologic and ultra-structural study of cellular toxic changes after electrochemical treatment in rat and dog liver. Bioelectrochemistry 59:89–98CrossRef

69.

von Euler H, Stråhle K, Thörne A, Yongqing G (2004) Cell proliferation and apoptosis in rat mammary cancer after electrochemical treatment (EChT). Bioelectrochemistry 62:57–65CrossRef

70.

Ikada Y, Tabata Y (1998) Protein release from gelatin matrices. Adv Drug Deliv Rev 31(3):287–301CrossRef

71.

Azab AK, Doviner V, Orkin B et al (2007) Biocompatibility evaluation of crosslinked chitosan hydrogels after subcutaneous and intraperitoneal implantation in the rat. J Biomed Mater Res, Part A 83(2):414–422CrossRef

72.

Muzzarelli RAA (2009) Genipin-crosslinked chitosan hydrogels as biomedical and pharmaceutical aids. Carbohyd Polym 77(1):1–9CrossRef

73.

Tan H, Li H, Rubin JP et al (2011) Controlled gelation and degradation rates of injectable hyaluronic acid-based hydrogels through a double crosslinking strategy. J Tissue Eng Regenerative Med 5(10):790–797CrossRef

74.

Wang X, Ren Y, Liu J (2018) Liquid metal enabled electrobiology: A generalized easy going way to tackle disease challenges. arXiv:1805.04002

Titel: Liquid Metal Enabled Injectable Biomedical Electronics
verfasst von: Jing Liu
Liting Yi
Verlag: Springer Singapore
Buch: Liquid Metal Biomaterials
Print ISBN: 978-981-10-5606-2

Electronic ISBN: 978-981-10-5607-9

Copyright-Jahr: 2018
DOI: https://doi.org/10.1007/978-981-10-5607-9_8

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