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Polymer Bulletin

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19.05.2021 | Original Paper

Micellization and gelation characteristics of different blends of pluronic F127/methylcellulose and their use as mucoadhesive in situ gel for periodontitis

verfasst von: Onpreeya Boonrat, Vimon Tantishaiyakul, Namon Hirun

Erschienen in: Polymer Bulletin | Ausgabe 7/2022

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Abstract

Micellization and gelation phenomena of thermosensitive hydrogels based on various concentrations of Pluronic F127 (PF) and 4% w/w methylcellulose (MC) were investigated by test tube inversion, turbidity, differential scanning calorimetry and rheological analyses. Dehydration of hydrophilic moieties of PF in the presence of MC was demonstrated by the clouding phenomenon. The involvement of MC on self-assembly and micelle formation of PF lowered the critical micelle temperature and enthalpy of micellization. The sol-to-gel temperature of the PF/MC blends decreased with increase PF concentrations. Neat samples of 12 or 14% w/w PF (12PF or 14PF, respectively) did not form gel, but their mixtures with MC (12PF/MC and 14PF/MC) were in sol form at ambient temperature (24 °C) and underwent gelation in situ at body temperature (37 °C). Both PF/MC blends were suitable as injectable implant matrices and their mucoadhesive properties were increased compared to pure PF. Doxycycline hyclate (DX), a model antibacterial drug for periodontitis, was incorporated into the 12PF/MC and 14PF/MC. The mixtures demonstrated the same antibacterial activity as the blend-free DX solution. This revealed that the hydrogel matrices did not impair the antibacterial activity of DX. Furthermore, the incorporation of DX into 12PF/MC and 14PF/MC hydrogels enabled the slow release of DX. These findings indicated that the 12PF/MC and 14PF/MC mixtures hold promise as efficient drug delivery systems for periodontitis.

Vorheriger Artikel Halloysite nanotubes/carbohydrate-based hydrogels for biomedical applications: from drug delivery to tissue engineering

Nächster Artikel Designing gelatin-based swellable hydrogels system for controlled delivery of salbutamol sulphate: characterization and toxicity evaluation

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Titel: Micellization and gelation characteristics of different blends of pluronic F127/methylcellulose and their use as mucoadhesive in situ gel for periodontitis
verfasst von: Onpreeya Boonrat
Vimon Tantishaiyakul
Namon Hirun
Publikationsdatum: 19.05.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: Polymer Bulletin / Ausgabe 7/2022
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI: https://doi.org/10.1007/s00289-021-03722-w

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