nach oben

Journal of Materials Science

Erschienen in:

11.07.2019 | Materials for life sciences

Modulation of biological properties by grain refinement and surface modification on titanium surfaces for implant-related infections

Erschienen in: Journal of Materials Science | Ausgabe 20/2019

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config

KI-gestützte Suche

Aus

Abstract

The nanostructured titanium (Ti) obtained by the equal-channel angular pressing (ECAP) has shown great promise as a biomedical implant material over the past few decades. The present work aims to investigate the effect of topographical changes caused by ECAP and piranha treatment (Tr) on the surface performance and biological properties of Ti for bone tissue engineering applications. The effects of dual treatments, i.e., ECAP and Tr, on Ti were systematically investigated by multiple characterization techniques, surface wettability, apatite-forming ability, cellular behavior, and antibacterial studies. We demonstrate that both ECAP and ECApTr samples possess desirable mechanical and physical properties and are biocompatible to cultured human fetal osteoblast (hFOB) cells. The potential of adhesion and proliferation of hFOB cells on ECAP and ECApTr samples was found to be superior to that of control unprocessed sample (annealed). Ti samples prepared by both methods showed excellent antimicrobial properties against clinical strains of the most common pathogenic bacteria causing orthopedic implant infections, Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa). This study supports the established claim about mechanical properties improvement by ultrafine refinement and further enhances the antibacterial properties when chemically etched with a piranha solution.

Vorheriger Artikel Biomineralization synthesis of HBc-CuS nanoparticles for near-infrared light-guided photothermal therapy

Nächster Artikel Efficient removal of Pb(II) by Ti3C2Tx powder modified with a silane coupling agent

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Simchi A, Tamjid E, Pishbin F, Boccaccini AR (2011) Recent progress in inorganic and composite coatings with bactericidal capability for orthopaedic applications. Nanomed Nanotechnol Biol Med 7(1):22–39. https://doi.org/10.1016/j.nano.2010.10.005 CrossRef

Hasan J, Crawford RJ, Ivanova EP (2013) Antibacterial surfaces: the quest for a new generation of biomaterials. Trends Biotechnol 31(5):295–304. https://doi.org/10.1016/j.tibtech.2013.01.017 CrossRef

Leventhal GS (1951) Titanium, a metal for surgery. J Bone Joint Surg 33(2):473–474CrossRef

Brånemark PI, Breine U, Johansson B, Roylance PJ, Röckert H, Yoffey JM (1964) Regeneration of bone marrow. Cells Tissues Organs 59(1–2):1–46. https://doi.org/10.1159/000142601 CrossRef

Long M, Rack HJ (1998) Titanium alloys in total joint replacement—a materials science perspective. Biomaterials 19(18):1621–1639. https://doi.org/10.1016/S0142-9612(97)00146-4 CrossRef

Niinomi M (2003) Recent research and development in titanium alloys for biomedical applications and healthcare goods. Sci Technol Adv Mater 4(5):445–454. https://doi.org/10.1016/j.stam.2003.09.002 CrossRef

Li Y, Yang C, Zhao H, Qu S, Li X, Li Y (2014) New developments of Ti-based alloys for biomedical applications. Materials 7(3):1709–1800. https://doi.org/10.3390/ma7031709 CrossRef

Morais LS, Serra GG, Albuquerque Palermo EF, Andrade LR, Müller CA, Meyers MA, Elias CN (2009) Systemic levels of metallic ions released from orthodontic mini-implants. Am J Orthod Dentofac Orthop 135(4):522–529. https://doi.org/10.1016/j.ajodo.2007.04.045 CrossRef

Okazaki Y, Gotoh E, Manabe T, Kobayashi K (2004) Comparison of metal concentrations in rat tibia tissues with various metallic implants. Biomaterials 25(28):5913–5920. https://doi.org/10.1016/j.biomaterials.2004.01.064 CrossRef

10.

Shettlemore MG, Bundy KJ (1999) Toxicity measurement of orthopedic implant alloy degradation products using a bioluminescent bacterial assay. J Biomed Mater Res 45(4):395–403. https://doi.org/10.1002/(SICI)1097-4636(19990615)45:4%3c395:AID-JBM15%3e3.0.CO;2-H CrossRef

11.

Valiev RZ, Estrin Y, Horita Z, Langdon TG, Zechetbauer MJ, Zhu YT (2006) Producing bulk ultrafine-grained materials by severe plastic deformation. JOM 58(4):33–39. https://doi.org/10.1007/s11837-006-0213-7 CrossRef

12.

Estrin Y, Vinogradov A (2013) Extreme grain refinement by severe plastic deformation: a wealth of challenging science. Acta Mater 61(3):782–817. https://doi.org/10.1016/j.actamat.2012.10.038 CrossRef

13.

Ratna Sunil B, Thirugnanam A, Chakkingal U, Sampath Kumar TS (2016) Nano and ultra fine grained metallic biomaterials by severe plastic deformation techniques. Mater Technol 31(13):743–755. https://doi.org/10.1080/10667857.2016.1249133 CrossRef

14.

Misra RDK, Thein-Han WW, Pesacreta TC, Somani MC, Karjalainen LP (2010) Biological significance of nanograined/ultrafine-grained structures: interaction with fibroblasts. Acta Biomater 6(8):3339–3348. https://doi.org/10.1016/j.actbio.2010.01.034 CrossRef

15.

Park J-W, Kim Y-J, Park CH, Lee D-H, Ko YG, Jang J-H, Lee CS (2009) Enhanced osteoblast response to an equal channel angular pressing-processed pure titanium substrate with microrough surface topography. Acta Biomater 5(8):3272–3280. https://doi.org/10.1016/j.actbio.2009.04.038 CrossRef

16.

Tan AW, Pingguan-Murphy B, Ahmad R, Akbar SA (2012) Review of titania nanotubes: fabrication and cellular response. Ceram Int 38(6):4421–4435. https://doi.org/10.1016/j.ceramint.2012.03.002 CrossRef

17.

Liu X, Chu PK, Ding C (2004) Surface modification of titanium, titanium alloys, and related materials for biomedical applications. Mater Sci Eng R Rep 47(3):49–121. https://doi.org/10.1016/j.mser.2004.11.001 CrossRef

18.

Lord MS, Modin C, Foss M, Duch M, Simmons A, Pedersen FS, Milthorpe BK, Besenbacher F (2006) Monitoring cell adhesion on tantalum and oxidised polystyrene using a quartz crystal microbalance with dissipation. Biomaterials 27(26):4529–4537. https://doi.org/10.1016/j.biomaterials.2006.04.006 CrossRef

19.

Jojibabu P, Ratna Sunil B, Sampath Kumar TS, Chakkingal U, Nandakumar V, Doble M (2013) Wettability and in vitro bioactivity studies on titanium rods processed by equal channel angular pressing. Trans Indian Inst Met 66(4):299–304. https://doi.org/10.1007/s12666-013-0281-7 CrossRef

20.

Variola F, Brunski J, Orsini G, de Oliveira PT, Wazen R, Nanci A (2011) Nanoscale surface modifications of medically-relevant metals: state-of-the art and perspectives. Nanoscale 3(2):335–353. https://doi.org/10.1039/c0nr00485e CrossRef

21.

de Oliveira PT, Zalzal SF, Beloti MM, Rosa AL, Nanci A (2007) Enhancement of in vitro osteogenesis on titanium by chemically produced nanotopography. J Biomed Mater Res Part A 80A(3):554–564. https://doi.org/10.1002/jbm.a.30955 CrossRef

22.

Webster TJ, Ejiofor JU (2004) Increased osteoblast adhesion on nanophase metals: Ti, Ti6Al4 V, and CoCrMo. Biomaterials 25(19):4731–4739. https://doi.org/10.1016/j.biomaterials.2003.12.002 CrossRef

23.

Popat KC, Leoni L, Grimes CA, Desai TA (2007) Influence of engineered titania nanotubular surfaces on bone cells. Biomaterials 28(21):3188–3197. https://doi.org/10.1016/j.biomaterials.2007.03.020 CrossRef

24.

Curtis A, Wilkinson C (1997) Topographical control of cells. Biomaterials 18(24):1573–1583. https://doi.org/10.1016/S0142-9612(97)00144-0 CrossRef

25.

Edwards KJ, Rutenberg AD (2001) Microbial response to surface microtopography: the role of metabolism in localized mineral dissolution. Chem Geol 180(1):19–32. https://doi.org/10.1016/S0009-2541(01)00303-5 CrossRef

26.

Tambasco de Oliveira P, Nanci A (2004) Nanotexturing of titanium-based surfaces upregulates expression of bone sialoprotein and osteopontin by cultured osteogenic cells. Biomaterials 25(3):403–413. https://doi.org/10.1016/S0142-9612(03)00539-8 CrossRef

27.

Seddiki O, Harnagea C, Levesque L, Mantovani D, Rosei F (2014) Evidence of antibacterial activity on titanium surfaces through nanotextures. Appl Surf Sci 308:275–284. https://doi.org/10.1016/j.apsusc.2014.04.155 CrossRef

28.

Sandeep Kranthi Kiran A, Sampath Kumar TS, Perumal G, Sanghavi R, Doble M, Ramakrishna S (2018) Dual nanofibrous bioactive coating and antimicrobial surface treatment for infection resistant titanium implants. Prog Org Coat 121:112–119. https://doi.org/10.1016/j.porgcoat.2018.04.028 CrossRef

29.

Mishra A, Kad BK, Gregori F, Meyers MA (2007) Microstructural evolution in copper subjected to severe plastic deformation: experiments and analysis. Acta Mater 55(1):13–28. https://doi.org/10.1016/j.actamat.2006.07.008 CrossRef

30.

Kokubo T, Takadama H (2006) How useful is SBF in predicting in vivo bone bioactivity? Biomaterials 27(15):2907–2915. https://doi.org/10.1016/j.biomaterials.2006.01.017 CrossRef

31.

Harris SA, Enger RJ, Riggs LB, Spelsberg TC (1995) Development and characterization of a conditionally immortalized human fetal osteoblastic cell line. J Bone Miner Res 10(2):178–186. https://doi.org/10.1002/jbmr.5650100203 CrossRef

32.

Kim TN, Balakrishnan A, Lee BC, Kim WS, Dvorankova B, Smetana K, Park JK, Panigrahi BB (2007) In vitro fibroblast response to ultra fine grained titanium produced by a severe plastic deformation process. J Mater Sci Mater Med 19(2):553–557. https://doi.org/10.1007/s10856-007-3204-5 CrossRef

33.

Bauer S, Schmuki P, von der Mark K, Park J (2013) Engineering biocompatible implant surfaces: Part I: materials and surfaces. Prog Mater Sci 58(3):261–326. https://doi.org/10.1016/j.pmatsci.2012.09.001 CrossRef

34.

Simi VS, Rajendran N (2017) Influence of tunable diameter on the electrochemical behavior and antibacterial activity of titania nanotube arrays for biomedical applications. Mater Charact 129:67–79. https://doi.org/10.1016/j.matchar.2017.04.019 CrossRef

35.

Attar H, Calin M, Zhang LC, Scudino S, Eckert J (2014) Manufacture by selective laser melting and mechanical behavior of commercially pure titanium. Mater Sci Eng A 593:170–177. https://doi.org/10.1016/j.msea.2013.11.038 CrossRef

36.

Ketabchi A, Komm K, Miles-Rossouw M, Cassani DAD, Variola F (2014) Nanoporous titanium surfaces for sustained elution of proteins and antibiotics. PLoS ONE 9(3):e92080. https://doi.org/10.1371/journal.pone.0092080 CrossRef

37.

Cochran DL, Schenk RK, Lussi A, Higginbottom FL, Buser D (1998) Bone response to unloaded and loaded titanium implants with a sandblasted and acid-etched surface: a histometric study in the canine mandible. J Biomed Mater Res 40(1):1–11. https://doi.org/10.1002/(sici)1097-4636(199804)40:1%3c1:aid-jbm1%3e3.0.co;2-q CrossRef

38.

Cho S-A, Park K-T (2003) The removal torque of titanium screw inserted in rabbit tibia treated by dual acid etching. Biomaterials 24(20):3611–3617. https://doi.org/10.1016/S0142-9612(03)00218-7 CrossRef

39.

Kaczmarek D, Domaradzki J, Wojcieszak D, Prociow E, Mazur M, Placido F, Lapp S (2012) Hardness of nanocrystalline TiO₂ thin films. J Nano Res 18–19:195–200. https://doi.org/10.4028/www.scientific.net/JNanoR.18-19.195 CrossRef

40.

Hajizadeh K, Eghbali B, Topolski K, Kurzydlowski KJ (2014) Ultra-fine grained bulk CP-Ti processed by multi-pass ECAP at warm deformation region. Mater Chem Phys 143(3):1032–1038. https://doi.org/10.1016/j.matchemphys.2013.11.001 CrossRef

41.

Zhang Y, Figueiredo RB, Alhajeri SN, Wang JT, Gao N, Langdon TG (2011) Structure and mechanical properties of commercial purity titanium processed by ECAP at room temperature. Mater Sci Eng A 528(25):7708–7714. https://doi.org/10.1016/j.msea.2011.06.054 CrossRef

42.

Nishimoto S, Bhushan B (2013) Bioinspired self-cleaning surfaces with superhydrophobicity, superoleophobicity, and superhydrophilicity. RSC Adv 3(3):671–690. https://doi.org/10.1039/C2RA21260A CrossRef

43.

Rupp F, Gittens RA, Scheideler L, Marmur A, Boyan BD, Schwartz Z, Geis-Gerstorfer J (2014) A review on the wettability of dental implant surfaces I: theoretical and experimental aspects. Acta Biomater 10(7):2894–2906. https://doi.org/10.1016/j.actbio.2014.02.040 CrossRef

44.

Shibata Y, Tanimoto Y (2015) A review of improved fixation methods for dental implants. Part I: surface optimization for rapid osseointegration. J Prosthodont Res 59(1):20–33. https://doi.org/10.1016/j.jpor.2014.11.007 CrossRef

45.

Hench L, Wilson J (1984) Surface-active biomaterials. Science 226(4675):630–636. https://doi.org/10.1126/science.6093253 CrossRef

46.

Tong WP, Tao NR, Wang ZB, Lu J, Lu K (2003) Nitriding iron at lower temperatures. Science 299(5607):686–688. https://doi.org/10.1126/science.1080216 CrossRef

47.

Yuan Y, Hays MP, Hardwidge PR, Kim J (2017) Surface characteristics influencing bacterial adhesion to polymeric substrates. RSC Adv 7(23):14254–14261. https://doi.org/10.1039/C7RA01571B CrossRef

48.

Skindersoe ME, Krogfelt KA, Blom A, Jiang G, Prestwich GD, Mansell JP (2015) Dual action of lysophosphatidate-functionalised titanium: interactions with human (MG63) osteoblasts and methicillin resistant Staphylococcus aureus. PLoS ONE 10(11):e0143509. https://doi.org/10.1371/journal.pone.0143509 CrossRef

49.

Lüdecke C, Roth M, Yu W, Horn U, Bossert J, Jandt KD (2016) Nanorough titanium surfaces reduce adhesion of Escherichia coli and Staphylococcus aureus via nano adhesion points. Colloids Surf B 145:617–625. https://doi.org/10.1016/j.colsurfb.2016.05.049 CrossRef

50.

Anselme K, Davidson P, Popa AM, Giazzon M, Liley M, Ploux L (2010) The interaction of cells and bacteria with surfaces structured at the nanometre scale. Acta Biomater 6(10):3824–3846. https://doi.org/10.1016/j.actbio.2010.04.001 CrossRef

51.

Puckett SD, Taylor E, Raimondo T, Webster TJ (2010) The relationship between the nanostructure of titanium surfaces and bacterial attachment. Biomaterials 31(4):706–713. https://doi.org/10.1016/j.biomaterials.2009.09.081 CrossRef

52.

Truong VK, Rundell S, Lapovok R, Estrin Y, Wang JY, Berndt CC, Barnes DG, Fluke CJ, Crawford RJ, Ivanova EP (2009) Effect of ultrafine-grained titanium surfaces on adhesion of bacteria. Appl Microbiol Biotechnol 83(5):925–937. https://doi.org/10.1007/s00253-009-1944-5 CrossRef

53.

Mitik-Dineva N, Wang J, Truong VK, Stoddart P, Malherbe F, Crawford RJ, Ivanova EP (2009) Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus attachment patterns on glass surfaces with nanoscale roughness. Curr Microbiol 58(3):268–273. https://doi.org/10.1007/s00284-008-9320-8 CrossRef

54.

Mitik-Dineva N, Wang J, Mocanasu RC, Stoddart PR, Crawford RJ, Ivanova EP (2008) Impact of nano-topography on bacterial attachment. Biotechnol J 3(4):536–544. https://doi.org/10.1002/biot.200700244 CrossRef

55.

Colon G, Ward BC, Webster TJ (2006) Increased osteoblast and decreased Staphylococcus epidermidis functions on nanophase ZnO and TiO₂. J Biomed Mater Res Part A 78A(3):595–604. https://doi.org/10.1002/jbm.a.30789 CrossRef

56.

Ploux L, Anselme K, Dirani A, Ponche A, Soppera O, Roucoules V (2009) Opposite responses of cells and bacteria to micro/nanopatterned surfaces prepared by pulsed plasma polymerization and UV-irradiation. Langmuir 25(14):8161–8169. https://doi.org/10.1021/la900457f CrossRef

57.

Preedy E, Perni S, Nipiĉ D, Bohinc K, Prokopovich P (2014) Surface roughness mediated adhesion forces between borosilicate glass and gram-positive bacteria. Langmuir 30(31):9466–9476. https://doi.org/10.1021/la501711t CrossRef

58.

Baek SM, Shin MH, Moon J, Jung HS, Lee SA, Hwang W, Yeom JT, Hahn SK, Kim HS (2017) Superior pre-osteoblast cell response of etched ultrafine-grained titanium with a controlled crystallographic orientation. Sci Rep 7:44213. https://doi.org/10.1038/srep44213 CrossRef

59.

Vetrone F, Variola F, Tambasco de Oliveira P, Zalzal SF, Yi J-H, Sam J, Bombonato-Prado KF, Sarkissian A, Perepichka DF, Wuest JD, Rosei F, Nanci A (2009) Nanoscale oxidative patterning of metallic surfaces to modulate cell activity and fate. Nano Lett 9(2):659–665. https://doi.org/10.1021/nl803051f CrossRef

Titel: Modulation of biological properties by grain refinement and surface modification on titanium surfaces for implant-related infections
Publikationsdatum: 11.07.2019
Erschienen in: Journal of Materials Science / Ausgabe 20/2019
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI: https://doi.org/10.1007/s10853-019-03811-2

Premium Partner

Marktübersichten

Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen.

Zur Marktübersicht

Springer Professional

Abstract

Bitte loggen Sie sich ein, um Zugang zu Ihrer Lizenz zu erhalten.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Technik"

Weitere Artikel der Ausgabe 20/2019

Flame retardant nanocomposites based on 2D layered nanomaterials: a review

Synthesis of foamed zinc oxide–silica spheres coupled with g-C3N4 nanosheets for visible light photocatalysis

Hybrid approach for augmenting the impact resistance of p-aramid fabrics: grafting of ZnO nanorods and impregnation of shear thickening fluid

Atomic mobility evaluation and diffusion matrix for fcc_A1 Co–V–W alloys

Effect of coatings on thermal conductivity and tribological properties of aluminum foam/polyoxymethylene interpenetrating composites

The influences of Mg intercalation on the structure and supercapacitive behaviors of MoS2

Premium Partner

Marktübersichten