Skip to main content

2014 | OriginalPaper | Buchkapitel

Multi-Agent-Based Simulation of Mycobacterium Tuberculosis Growth

verfasst von : Pablo Werlang, Michel Q. Fagundes, Diana F. Adamatti, Karina S. Machado, Andrea von Groll, Pedro E. A. da Silva, Adriano V. Werhli

Erschienen in: Multi-Agent-Based Simulation XIV

Verlag: Springer Berlin Heidelberg

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Tuberculosis is an infectious disease that still causes many deaths around the world nowadays. It is caused by the M. tuberculosis bacillus. The study of the growth curve of this infectious organism is relevant as it has wide applications in tuberculosis research. In this work a Multi-Agent-Based Simulation is proposed to pursue the reproduction in silico of the observed in vitro M. tuberculosis growth curves. Simulation results are qualitatively compared with growth curves obtained in vitro with a recent proposed methodology. The results are promising and indicate that the chosen simulation methodology has the potential to serve as a platform for testing different bacterial growing behaviour as well as bacteria growth under different conditions.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Literatur
1.
Zurück zum Zitat Barkan, D., Liu, Z., Sacchettini, J., Glickman, M.: Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis. Chem. Biol. 16, 499–509 (2009)CrossRef Barkan, D., Liu, Z., Sacchettini, J., Glickman, M.: Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis. Chem. Biol. 16, 499–509 (2009)CrossRef
2.
Zurück zum Zitat Chan, E.D., Iseman, M.D.: Multidrug-resistant and extensively drug-resistant tuberculosis: a review. Curr. Opin. Infect. Dis. 21(6), 587–595 (2008)CrossRef Chan, E.D., Iseman, M.D.: Multidrug-resistant and extensively drug-resistant tuberculosis: a review. Curr. Opin. Infect. Dis. 21(6), 587–595 (2008)CrossRef
3.
Zurück zum Zitat Chien, H., Yu, M., Wu, M., Lin, T., Luh, K.: Comparison of the BACTEC MGIT 960 with Löwenstein-Jensen medium for recovery of mycobacteria from clinical specimens. Int. J. Tuberc. Lung Dis. 4(9), 866–870 (2000) Chien, H., Yu, M., Wu, M., Lin, T., Luh, K.: Comparison of the BACTEC MGIT 960 with Löwenstein-Jensen medium for recovery of mycobacteria from clinical specimens. Int. J. Tuberc. Lung Dis. 4(9), 866–870 (2000)
4.
Zurück zum Zitat Conte, R., Gilbert, N., Sichman, J.S.: MAS and social simulation: a suitable commitment. In: Sichman, J.S., Conte, R., Gilbert, N. (eds.) MABS 1998. LNCS (LNAI), vol. 1534, pp. 1–9. Springer, Heidelberg (1998) Conte, R., Gilbert, N., Sichman, J.S.: MAS and social simulation: a suitable commitment. In: Sichman, J.S., Conte, R., Gilbert, N. (eds.) MABS 1998. LNCS (LNAI), vol. 1534, pp. 1–9. Springer, Heidelberg (1998)
5.
Zurück zum Zitat Damato, J.J., Collins, M.T., Rothlauf, M.V., McClatchy, J.K.: Detection of mycobacteria by radiometric and standard plate procedures. J. Clin. Microbiol. 17, 1066–1073 (1983) Damato, J.J., Collins, M.T., Rothlauf, M.V., McClatchy, J.K.: Detection of mycobacteria by radiometric and standard plate procedures. J. Clin. Microbiol. 17, 1066–1073 (1983)
6.
Zurück zum Zitat Drogoul, A., Ferber, J.: Multi-agent simulation as a tool for modeling societies: application to social differentiation in ant colonies. In: Proceedings of Workshop on Modelling Autonomous Agents in a Multi-Agent World (1992) Drogoul, A., Ferber, J.: Multi-agent simulation as a tool for modeling societies: application to social differentiation in ant colonies. In: Proceedings of Workshop on Modelling Autonomous Agents in a Multi-Agent World (1992)
7.
Zurück zum Zitat Gilbert, N., Troitzsch, K.G.: Simulation for the Social Scientist. Open University Press, Buckingham and Philadelphia (2005) Gilbert, N., Troitzsch, K.G.: Simulation for the Social Scientist. Open University Press, Buckingham and Philadelphia (2005)
8.
Zurück zum Zitat von Groll, A., Martin, A., Stehr, M., Singh, M., Portaels, F., da Silva, P.E.A., Palomino, J.C.: Fitness of Mycobacterium tuberculosis strains of the W-Beijing and Non-W-Beijing genotype. PLoS ONE 5(4), e10191 (2010)CrossRef von Groll, A., Martin, A., Stehr, M., Singh, M., Portaels, F., da Silva, P.E.A., Palomino, J.C.: Fitness of Mycobacterium tuberculosis strains of the W-Beijing and Non-W-Beijing genotype. PLoS ONE 5(4), e10191 (2010)CrossRef
9.
Zurück zum Zitat Lambrecht, R.S., Carriere, J.F., Collins, M.T.: A model for analyzing growth kinetics of a slowly growing Mycobacterium sp. Appl. Environ. Microbiol. 54, 910–916 (1988) Lambrecht, R.S., Carriere, J.F., Collins, M.T.: A model for analyzing growth kinetics of a slowly growing Mycobacterium sp. Appl. Environ. Microbiol. 54, 910–916 (1988)
10.
Zurück zum Zitat Meyers, P., Bourn, W., Steyn, L., van Helden, P., Beyers, A., Brown, G.: Novel method for rapid measurement of growth of mycobacteria in detergent-free media. J. Clin. Microbiol. 36(9), 2752–2754 (1998) Meyers, P., Bourn, W., Steyn, L., van Helden, P., Beyers, A., Brown, G.: Novel method for rapid measurement of growth of mycobacteria in detergent-free media. J. Clin. Microbiol. 36(9), 2752–2754 (1998)
12.
Zurück zum Zitat Pheiffer, C., Carroll, N., Beyers, N., Donald, P., Duncan, K., Uys, P., van Helden, P.: Time to detection of Mycobacterium tuberculosis in BACTEC systems as a viable alternative to colony counting. Int. J. Tuberc. Lung Dis. 12(7), 792–798 (2008) Pheiffer, C., Carroll, N., Beyers, N., Donald, P., Duncan, K., Uys, P., van Helden, P.: Time to detection of Mycobacterium tuberculosis in BACTEC systems as a viable alternative to colony counting. Int. J. Tuberc. Lung Dis. 12(7), 792–798 (2008)
13.
Zurück zum Zitat Buchanan, R.L., Whiting, R.C.W., Damert, W.C.: When is simple good enough: a comparison of the Gompertz, Baranyi, and three-phase linear models for fitting bacterial growth curves. Food Microbiol. 14, 313–326 (1997)CrossRef Buchanan, R.L., Whiting, R.C.W., Damert, W.C.: When is simple good enough: a comparison of the Gompertz, Baranyi, and three-phase linear models for fitting bacterial growth curves. Food Microbiol. 14, 313–326 (1997)CrossRef
14.
Zurück zum Zitat Sassetti, C., Boyd, D., Rubin, E.: Genes required for mycobacterial growth defined by high density mutagenesis. Mol. Microbiol. 48(1), 77–84 (2003)CrossRef Sassetti, C., Boyd, D., Rubin, E.: Genes required for mycobacterial growth defined by high density mutagenesis. Mol. Microbiol. 48(1), 77–84 (2003)CrossRef
15.
Zurück zum Zitat Sifri, C.D.: Quorum sensing: bacteria talk sense. Clin. Infect. Dis. 47(8), 1070–1076 (2008)CrossRef Sifri, C.D.: Quorum sensing: bacteria talk sense. Clin. Infect. Dis. 47(8), 1070–1076 (2008)CrossRef
17.
Zurück zum Zitat Verma, A., Sampla, A., Tyagi, J.: Mycobacterium tuberculosis rrn promoters: differential usage and growth rate-dependent control. J. Bacteriol. 181(14), 4326–4333 (1999) Verma, A., Sampla, A., Tyagi, J.: Mycobacterium tuberculosis rrn promoters: differential usage and growth rate-dependent control. J. Bacteriol. 181(14), 4326–4333 (1999)
18.
Zurück zum Zitat Voskuil, M., Visconti, K., Schoolnik, G.: Mycobacterium tuberculosis gene expression during adaptation to stationary phase and low-oxygen dormancy. Tuberculosis (Edinb) 84(3–4), 218–227 (2004)CrossRef Voskuil, M., Visconti, K., Schoolnik, G.: Mycobacterium tuberculosis gene expression during adaptation to stationary phase and low-oxygen dormancy. Tuberculosis (Edinb) 84(3–4), 218–227 (2004)CrossRef
19.
Zurück zum Zitat Walters, S.B., Hanna, B.A.: Testing of susceptibility of Mycobacterium tuberculosis to isoniazid and rifampin by mycobacterium growth indicator tube method. J. Clin. Microbiol. 34, 1565–1567 (1996) Walters, S.B., Hanna, B.A.: Testing of susceptibility of Mycobacterium tuberculosis to isoniazid and rifampin by mycobacterium growth indicator tube method. J. Clin. Microbiol. 34, 1565–1567 (1996)
20.
Zurück zum Zitat Wooldridge, M.: An Introduction to MultiAgent Systems. John Wiley & Sons, New York (2009) Wooldridge, M.: An Introduction to MultiAgent Systems. John Wiley & Sons, New York (2009)
Metadaten
Titel
Multi-Agent-Based Simulation of Mycobacterium Tuberculosis Growth
verfasst von
Pablo Werlang
Michel Q. Fagundes
Diana F. Adamatti
Karina S. Machado
Andrea von Groll
Pedro E. A. da Silva
Adriano V. Werhli
Copyright-Jahr
2014
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-642-54783-6_9

Premium Partner